Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo.
1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. In vitro and in vivo studies revealed that CP induced but did not activate delta-aminolaevulinic acid (ALA) syntha...
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| Otros Autores: | , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1992
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 04075caa a22007457a 4500 | ||
|---|---|---|---|
| 001 | PAPER-334 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518202942.0 | ||
| 008 | 140217s1992 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0026867390 | |
| 024 | 7 | |2 pubmed |a 1358518 | |
| 024 | 7 | |2 cas |a 5 aminolevulinate synthase, 9037-14-3; acrolein, 107-02-8; allylisopropylacetamide, 299-78-5; cyclophosphamide, 50-18-0; cytochrome P450, 9035-51-2; phenobarbital, 50-06-6, 57-30-7, 8028-68-0; porphyrin, 24869-67-8; proadifen, 302-33-0, 62-68-0; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Acrolein, 107-02-8; Allylisopropylacetamide, 299-78-5; Cyclophosphamide, 50-18-0; Cytochrome P-450 Enzyme System, 9035-51-2; Phenobarbital, 50-06-6; Porphyrins; Proadifen, 302-33-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Cochón, A.C. | |
| 245 | 1 | 0 | |a Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo. |
| 260 | |c 1992 | ||
| 270 | 1 | 0 | |m Cochón, A.C. |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a 1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. In vitro and in vivo studies revealed that CP induced but did not activate delta-aminolaevulinic acid (ALA) synthase. 3. Pretreatments with phenobarbital (PB) or SKF-525A did not modify ALA-synthase induction produced by CP. 4. Acrolein administration neither induced ALA-synthase activity nor increased cytochrome P-450 content or led to hepatic porphyrin accumulation. 5. Time course induction of cytochrome P-450 content after administration of CP or PB was similar. 6. The results obtained would indicate that CP is a strong inducer of both ALA-synthase activity and microsomal cytochrome P-450 content in liver of 17 day-old chick embryos and that its porphyrinogenic activity is not mediated by its metabolite acrolein. |l eng | |
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina. | ||
| 690 | 1 | 0 | |a 5 AMINOLEVULINATE SYNTHASE |
| 690 | 1 | 0 | |a ACROLEIN |
| 690 | 1 | 0 | |a ALLYLISOPROPYLACETAMIDE |
| 690 | 1 | 0 | |a CYCLOPHOSPHAMIDE |
| 690 | 1 | 0 | |a CYTOCHROME P 450 ENZYME SYSTEM |
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a PROADIFEN |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a CHEMICAL STRUCTURE |
| 690 | 1 | 0 | |a CHEMISTRY |
| 690 | 1 | 0 | |a CHICK EMBRYO |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a ENZYMOLOGY |
| 690 | 1 | 0 | |a GESTATIONAL AGE |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a 5-AMINOLEVULINATE SYNTHETASE |
| 690 | 1 | 0 | |a ACROLEIN |
| 690 | 1 | 0 | |a ALLYLISOPROPYLACETAMIDE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CHICK EMBRYO |
| 690 | 1 | 0 | |a CYCLOPHOSPHAMIDE |
| 690 | 1 | 0 | |a CYTOCHROME P-450 ENZYME SYSTEM |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a GESTATIONAL AGE |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MOLECULAR STRUCTURE |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a PROADIFEN |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 700 | 1 | |a San Martín de Viale, L.C. | |
| 700 | 1 | |a Wainstok de Calmanovici, R. | |
| 773 | 0 | |d 1992 |g v. 102 |h pp. 143-148 |k n. 1 |p Comp Biochem Physiol C |x 07428413 |t Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology | |
| 856 | 4 | 1 | |u http://www.scopus.com/inward/record.url?eid=2-s2.0-0026867390&partnerID=40&md5=31d09a0addc85ce3c1214b711cde48e0 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_07428413_v102_n1_p143_Cochon |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07428413_v102_n1_p143_Cochon |y Registro en la Biblioteca Digital |
| 961 | |a paper_07428413_v102_n1_p143_Cochon |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 61287 | ||