Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
A great deal of information concerning the effects of hexachlorobenzene on the haem metabolic pathway has been obtained but little is known about the effects of the drug on lipid metabolism, Consequently, the time course of phospholipid metabolism alteration caused by this xenobiotic was evaluated a...
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1997
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| LEADER | 11574caa a22011537a 4500 | ||
|---|---|---|---|
| 001 | PAPER-3327 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203247.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0030896955 | |
| 024 | 7 | |2 cas |a Fungicides, Industrial; Hexachlorobenzene, 118-74-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IJBBF | ||
| 100 | 1 | |a Billi De Catabbi, S. | |
| 245 | 1 | 0 | |a Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria |
| 260 | |c 1997 | ||
| 270 | 1 | 0 | |m San Martin de Viale, L.O'Higgins 4332, Capital 1429 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Courtney, K.D., Hexachlorobenzene (HCB): A review (1979) Environ. Res., 20, pp. 225-266 | ||
| 504 | |a Elder, G.H., Evans, J.O., Matlin, S.A., The effect of porphyrinogenic compound hexachlorobenzene on the activity of uroporphyrinogen decarboxylase in rat liver (1976) Clin. Sci. Mol. Med., 51, pp. 71-80 | ||
| 504 | |a Feldman, E.S., Bacon, B.R., Hepatic mitochondrial oxidative metabolism and lipid peroxidation in experimental hexachlorobenzene-induced porphyria with dietary carbonyl iron overload (1989) Hepatology, 9, pp. 686-692 | ||
| 504 | |a Ferioli, A., Harvey, C., De Matteis, F., Drug-induced accumulation of uroporphyrin in chicken hepatocyte cultures (1984) Biochem. J., 224, pp. 769-777 | ||
| 504 | |a Francis, J.E., Smith, A.G., Oxidation of uroporphyrinogens by hydroxyl radicals. Evidence for nonporphyrin products as potential inhibitors of uroporphyrinogen decarboxylase (1988) FEBS Lett., 233, pp. 311-314 | ||
| 504 | |a Goel, M.R., Shara, M.A., Stohs, S.J., Induction of lipid peroxidation by hexachlorocyclohexane Dieldrin, TCDD, Carbon tetrachloride and Hexachlorobenzene in rats (1988) Bull. Environm. Contam. Toxicol., 40, pp. 255-262 | ||
| 504 | |a Ishidate, K., Nakazawa, Y., Effect of polychlorinated biphenyls administration on phospholipid biosynthesis in rat liver (1976) Biochem. Pharmacol., 25, pp. 1255-1260 | ||
| 504 | |a Koszo, F., Horvath, L.I., Simon, N., Siklosi, C., Kiss, M., The role of possible membrane damage in porphyria cutanea tarda. A spin label study of rat liver cell membrane (1982) Biochem. Pharmacol., 31, pp. 11-17 | ||
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| 504 | |a Lissner, R., Goerz, G., Eichenauer, M.G., Ippen, H., Hexachlorobenzene induced porphyria in rats. Relationship between porphyrin excretion and induction of drug metabolizing liver enzymes (1975) Biochem. Pharmacol., 24, pp. 1729-1731 | ||
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| 504 | |a Miller, D.M., Woods, J.S., Urinary porphyrins as Biological indicators of oxidative stress in the kidney. Interaction of mercury and cephaloridine (1993) Biochem. Pharmacol., 46, pp. 2235-2241 | ||
| 504 | |a Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxids in animal tissues by thiobarbituric acid reaction (1979) Anal. Biochem., 95, pp. 351-358 | ||
| 504 | |a Recknagel, R.O., Ghoshal, A.K., Quantitative estimation of peroxidative degeneration of rat liver microsomal and mitochondrial lipids after carbon tetrachloride poisoning (1966) Experimental and Molecular Pathology, 5, pp. 413-426 | ||
| 504 | |a Ríos De Molina, M.C., Wainstok De Calmanovici, R., San Martin De Viale, L.C., Investigations on the presence of porphyrinogen carboxylyase inhibitor in liver of rats intoxicated with hexachlorobenzene (1980) Int. J. Biochem., 12, pp. 1027-1032 | ||
| 504 | |a Rizzardini, M., Graziani, A., Carugo, C., Cantoni, L., Investigations on the role of free radical processes in hexachlorobenzene-induced porphyria in mice (1988) J. Biochem. Toxicol., 3, pp. 33-46 | ||
| 504 | |a San Martin De Viale, L.C., Ríos De Molina, M.C., Wainstok De Calmanovici, R., Tomio, J.M., Porphyrins and porphyrinogen carboxylyase in hexachlorobenzene induced porphyria (1977) Biochem. J., 168, pp. 393-400 | ||
| 504 | |a Schmid, R., Cutaneous porphyria in Turkey (1960) New Engl. J. Med., 263, pp. 397-398 | ||
| 504 | |a Skipski, V.P., Peterson, R.E., Barclay, M., Quantitative analysis of pospholipids by thin-layer chromatography (1964) Biochem. J., 90, pp. 374-378 | ||
| 504 | |a Smith, A.G., Francis, J.E., Chemically-induced formation of an inhibitor of hepatic uroporphyrinogen decarboxylase in imbred mice with iron overload (1987) Biochem. J., 246, pp. 221-226 | ||
| 504 | |a Strobel, H.W., Lu, A.Y.H., Heidema, J., Coon, M.J., Phosphatidylcholine requirement in the enzymatic reduction of hemoprotein P-450 and in fatty acid, hydrocarbon and drug hydroxylation (1970) J. Biol. Chem., 245, pp. 4851-4856 | ||
| 504 | |a Wada, O., Toyokawa, K., Urata, G., Yano, Y., Nakav, K., Cholesterol biosynthesis in the liver of experimental induced porphyric mice (1969) Biochem. Pharmacol., 18, pp. 1533-1535 | ||
| 504 | |a Wainstok De Calmanovici, R., Ríos De Molina, M.C., Taira De Yamasato, M.C., Tomio, J.M., San Martin De Viale, L.C., Mechanism of hexachlorobenzene induced porphyria in rats. Effect of phenobarbitone pretreatment (1984) Biochem. J., 218, pp. 753-763 | ||
| 504 | |a Weiss, S.J., McKinney, J.S., Putney J.W., Jr., Regulation of phosphatidate synthesis by secretagogues in parotid acinar cells (1982) Biochem. J., 204, pp. 587-592 | ||
| 504 | |a Wilson, J., Kueberuwa, S.S., (1994) Toxicological Profile for Hexachlorobenzene, , Update. U.S. Department of Health and Human Services. Public Health Service Agency for Toxic Substances and Disease Registry | ||
| 520 | 3 | |a A great deal of information concerning the effects of hexachlorobenzene on the haem metabolic pathway has been obtained but little is known about the effects of the drug on lipid metabolism, Consequently, the time course of phospholipid metabolism alteration caused by this xenobiotic was evaluated as related to changes in porphyrin metabolism with the aim to understand better the interregulation of both metabolisms. Female Wistar rats were treated with HCB (1 g/kg) over a 1-8 week period. Individual phospholipid content, [32P] incorporation, total lipid content, lipid peroxidation, uroporphyrinogen decarboxylase activity, its inhibitor generation and porphyrin content, were the parameters measured in the liver of treated rats. Phospholipid metabolism - with the exception of sphingomyelin-presents a biphasic behaviour, in both the endogenous contents and de novo synthesis. The turning point between both phases is the time at which levels of porphyrin and conjugated dienes increase, the latter compounds being involved in oxidative processes. On the other hand, sphingomyelin decreases continuously during the 8 weeks of treatment. It mas also found that the malondialdehyde content increased during the early stages. The time sequence for haem metabolism parameters showed that the accumulation of porphyrins occurs after the decrease in uroporphyrinogen decarboxylase activity and the enzyme inhibitor formation, which are early events (first and second weeks). Porphyrins could not by themselves exacerbate uroporphyrinogen decarboxylase impairment or inhibitor generation. This study shows that hexachlorobenzene alters simultaneously phospholipid and porphyrin metabolisms from the early stages, and generates an oxidative environment that favours porphyrinogens and lipid oxidation at later stages. So, this oxidative environment links the alterations on both metabolisms. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Acknowled~ements~This work was partly supported by grants from the CONICET (Consejo National de Investigaciones Cientificas y Tkcnicas) and from the University of Buenos Aires. L. C. San Martin de Viale and N. B. Sterin-Speziale are Scientific Research Career members of the CONICET. | ||
| 593 | |a Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Fac. de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a O'Higgins 4332, Capital 1429, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a LIPID PEROXIDATION |
| 690 | 1 | 0 | |a PHOSPHOLIPID |
| 690 | 1 | 0 | |a PORPHYRIA |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a PHOSPHOLIPID |
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a UROPORPHYRINOGEN DECARBOXYLASE |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a LIPID PEROXIDATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PHOSPHOLIPID METABOLISM |
| 690 | 1 | 0 | |a PORPHYRIA |
| 690 | 1 | 0 | |a PORPHYRIN METABOLISM |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FUNGICIDES, INDUSTRIAL |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a LIPID METABOLISM |
| 690 | 1 | 0 | |a LIPID PEROXIDATION |
| 690 | 1 | 0 | |a PORPHYRIAS |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, WISTAR |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a RATTUS NORVEGICUS |
| 700 | 1 | |a Sterin-Speziale, N. | |
| 700 | 1 | |a Fernandez, M.C. | |
| 700 | 1 | |a Minutolo, C. | |
| 700 | 1 | |a Aldonatti, C. | |
| 700 | 1 | |a San Martin De Viale, L. | |
| 773 | 0 | |d 1997 |g v. 29 |h pp. 335-344 |k n. 2 |p INT. J. BIOCHEM. CELL BIOL. |x 13572725 |w (AR-BaUEN)CENRE-5218 |t International Journal of Biochemistry and Cell Biology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_13572725_v29_n2_p335_BilliDeCatabbi |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13572725_v29_n2_p335_BilliDeCatabbi |y Registro en la Biblioteca Digital |
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