Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells
Acquisition of invasive/metastatic potential is a key event in tumor progression. Cell surface glycoproteins and their respective matrix ligands have been implicated in this process. Recent evidence reveals that the secreted glycoprotein SPARC (secreted protein, acidic and rich in cysteine) is highl...
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| Otros Autores: | , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1997
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 06425caa a22009497a 4500 | ||
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| 001 | PAPER-3313 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203246.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0031056656 | |
| 024 | 7 | |2 cas |a Oligonucleotides, Antisense; Osteonectin | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NAMEF | ||
| 100 | 1 | |a Fernanda Ledda, M. | |
| 245 | 1 | 0 | |a Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells |
| 260 | |c 1997 | ||
| 270 | 1 | 0 | |m Podhajcer, O.L.; Inst. de Investigaciones Bioquimicas, Fundacion Campomar, IIBBA-CONICET, Patricias Argentinas 435, 1405 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Stetler-Stevenson, W.G., Aznavoorian, S., Liotta, L.A., Tumor cell interactions with the extracellular matrix during invasion and metastasis (1993) Annu. Rev. Cell Biol., 9, pp. 541-573 | ||
| 504 | |a Stetler-Stevenson, W.G., Liotta, L.A., Kleiner, D.E., Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis (1993) FASEB J., 7, pp. 1434-1441 | ||
| 504 | |a Albelda, S.M., Role of integrins and other cell adhesion molecules in tumor progression and metastasis (1993) Lab. Invest., 68, pp. 4-17 | ||
| 504 | |a Wewer, U.M., Taraboletti, G., Sobel, M.E., Albrechtsen, R., Liotta, L.A., Role of laminin receptors in tumor cell migration (1987) Cancer Res., 47, pp. 5691-5698 | ||
| 504 | |a Lane, T.F., Sage, E.H., The biology of SPARC, a protein that modulates cell-matrix interactions (1994) FASEB J., 8, pp. 163-173 | ||
| 504 | |a Sage, E.H., Bornstein, P., Extracellular proteins that modulate cell-matrix interactions (1991) J. Biol. Chem., 266, pp. 14831-14834 | ||
| 504 | |a Tremble, P.M., Lane, T.F., Sage, E.H., Werb, Z., SPARC, a secreted protein associated with morphogenesis and tissue remodelling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway (1993) J. Cell Biol., 121, pp. 1433-1444 | ||
| 504 | |a Porter, P.L., Sage, E.H., Lane, T.F., Funk, S.H., Gown, A.M., Distribution of SPARC in normal and neoplastic tissue (1995) J. Histochem. Cytochem., 43, pp. 791-800 | ||
| 504 | |a Podhajcer, O.L., Comparative expression of the SPARC and stromelysin-3 genes in mammary tumors (1996) Breast, 5, pp. 13-20 | ||
| 504 | |a Bellahcene, A., Castronovo, V., Increased expression of osteonectin and osteopontin, two bone matrix proteins, in human breast cancer (1995) Am. J. Pathol., 146, pp. 95-100 | ||
| 504 | |a Porte, H., Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin-3 and BM-40/SPARC genes (1995) Int. J. Cancer, 64, pp. 70-75 | ||
| 504 | |a Ledda, F., The expression of the secreted protein acidic and rich in cysteine, SPARC, is associated with the neoplastic progression of human melanoma J. Invest. Dermatol., , in the press | ||
| 504 | |a Podhajcer, O.L., Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi (1995) J. Invest. Dermatol., 104, pp. 340-1144 | ||
| 504 | |a Terranova, V.P., Williams, J.E., Liotta, L.E., Martin, C.R., Modulation of the metastatic activity of melanoma cells by laminin and fibronectin (1984) Science, 226, pp. 982-985 | ||
| 520 | 3 | |a Acquisition of invasive/metastatic potential is a key event in tumor progression. Cell surface glycoproteins and their respective matrix ligands have been implicated in this process. Recent evidence reveals that the secreted glycoprotein SPARC (secreted protein, acidic and rich in cysteine) is highly expressed in different malignant tissues. The present study reports that the suppression of SPARC expression by human melanoma cells using a SPARC antisense expression vector results in a significant decrease in the in vitro adhesive and invasive capacities of tumor cells, completely abolishing their in vivo tumorigenicity. This is the first evidence that SPARC plays a key role in human melanoma invasive-metastatic phenotype development. |l eng | |
| 593 | |a Lnstituto de Invest. Bioquimicas, Fundacion Campomar, IIBBA-CONICET, Patricias Argentinas 435, 1405 Buenos Aires, Argentina | ||
| 593 | |a Fac. Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina | ||
| 593 | |a Hospital E. Peron, Balcarce 900, 1650 Provincia de Buenos Aires, Argentina | ||
| 593 | |a Kennedy Institute of Rheumatology, 6 Bute Gardens, London W6 7DW, United Kingdom | ||
| 690 | 1 | 0 | |a COMPLEMENTARY RNA |
| 690 | 1 | 0 | |a GLYCOPROTEIN |
| 690 | 1 | 0 | |a OSTEONECTIN |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CANCER INHIBITION |
| 690 | 1 | 0 | |a CANCER INVASION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a MELANOMA CELL |
| 690 | 1 | 0 | |a METASTASIS |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CELL ADHESION |
| 690 | 1 | 0 | |a CELL DIVISION |
| 690 | 1 | 0 | |a CELL MOVEMENT |
| 690 | 1 | 0 | |a DOWN-REGULATION |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION, NEOPLASTIC |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MELANOMA |
| 690 | 1 | 0 | |a MELANOMA, EXPERIMENTAL |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a OLIGONUCLEOTIDES, ANTISENSE |
| 690 | 1 | 0 | |a OSTEONECTIN |
| 690 | 1 | 0 | |a TRANSFECTION |
| 690 | 1 | 0 | |a TUMOR CELLS, CULTURED |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Adris, S. | |
| 700 | 1 | |a Bravo, A.I. | |
| 700 | 1 | |a Kairiyama, C. | |
| 700 | 1 | |a Bover, L. | |
| 700 | 1 | |a Chernajovsky, Y. | |
| 700 | 1 | |a Mordoh, J. | |
| 700 | 1 | |a Podhajcer, O.L. | |
| 773 | 0 | |d 1997 |g v. 3 |h pp. 171-176 |k n. 2 |p NAT. MED. |x 10788956 |w (AR-BaUEN)CENRE-6218 |t Nature Medicine | |
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| 856 | 4 | 0 | |u https://doi.org/10.1038/nm0297-171 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_10788956_v3_n2_p171_FernandaLedda |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10788956_v3_n2_p171_FernandaLedda |y Registro en la Biblioteca Digital |
| 961 | |a paper_10788956_v3_n2_p171_FernandaLedda |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 64266 | ||