Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was als...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1997
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 12304caa a22012857a 4500 | ||
|---|---|---|---|
| 001 | PAPER-3290 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203245.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0030961746 | |
| 024 | 7 | |2 cas |a 5-Aminolevulinate Synthetase, EC 2.3.1.37; Aminolevulinic Acid, 106-60-5; Anesthetics, Inhalation; Cytochrome P-450 Enzyme System, 9035-51-2; Enflurane, 13838-16-9; Heme, 14875-96-8; Hypnotics and Sedatives; Isoflurane, 26675-46-7; Phenobarbital, 50-06-6; Porphobilinogen, 487-90-1; Porphyrins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a GEPHD | ||
| 100 | 1 | |a Buzaleh, A.M. | |
| 245 | 1 | 0 | |a Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation |
| 260 | |c 1997 | ||
| 270 | 1 | 0 | |m Del Carmen Batlle, A.M.Viamonte 1881 'A', 1056 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Allan, L.G., Hussey, A.J., Howie, J., Beckett, G.J., Smith, A.F., Hayes, J.D., Drummond, G.B., Hepatic glutathione S-transferases release after halothane anaesthesia: Open randomised comparison with Isoflurane (1987) Lancet, 1, pp. 771-773 | ||
| 504 | |a Alterman, M.A., Carvan, M.J., Busbee, D.L., Dose-dependent induction of the microsomal monooxygenase system by phenobarbital and 3-methylcolanthrene in the ad libitum and calorie-restricted female rat (1995) Xenobiotics, 25, pp. 17-26 | ||
| 504 | |a Barr, G.A., Cousins, M.G., Mazze, R.I., Hitt, B.A., Kosek, J.C., A comparison of the renal effects and metabolism of enflurane and methoxyflurane in Fischer 344 rats (1974) J. Pharmac. Exp. Ther., 188, pp. 257-264 | ||
| 504 | |a Batt, A.M., Magdalou, J., Vincentviry, M., Ouzzine, M., Fournelgigleux, S., Galteau, M.M., Siest, G., Drug metabolizing enzymes related to laboratory medicine: Cytochromes P-450 and UDP-glucuronosyltransferases (1994) Clin. Chim. Acta, 225, pp. 171-190 | ||
| 504 | |a Buzaleh, A.M., Enriquez de Salamanca, R., Del C Batlle, A.M., Porphyrinogenic properties of the anesthetic Enflurane (1992) Gen. Pharmac., 23, pp. 665-669 | ||
| 504 | |a Buzaleh, A.M., Enriquez de Salamanca, R., Del C Batlle, A.M., Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria? (1992) J. Pharmac. Meth., 28, pp. 191-197 | ||
| 504 | |a Buzaleh, A.M., Vazquez, E., Batlle, A.M.D.C., Changes in heme metabolism and its regulation following chronic exposure to Enflurane and Isoflurane anesthesia (1995) Pharmac. Commun., 7, pp. 43-50 | ||
| 504 | |a Dooley, J.R., Mazze, R.I., Rice, S.A., Borel, J.D., Is enflurane defluorination inducible in man? (1979) Anesthesiology, 50, pp. 213-217 | ||
| 504 | |a El-Mouelhi, M., Didolkar, M.S., Elias, E.G., Guengerich, F.P., Kauffman, F.C., Hepatic drug-metabolizing enzymes in primary and secondary tumors of human liver (1987) Cancer Res., 47, pp. 460-466 | ||
| 504 | |a Gillette, J.R., Davies, D.C., Sasame, H.A., Cytochrome P-450 and its role in drug metabolism (1972) Annu. Rev. Pharmac., 12, pp. 57-84 | ||
| 504 | |a Granick, S., The induction in vitro of the synthesis of 5-aminolaevulinic acid synthetase in chemical porphyria. A response to certain drugs, sex hormones, and foreign chemicals (1966) J. Biol. Chem., 241, pp. 1359-1375 | ||
| 504 | |a Granick, S., Urata, G., Increase in the activity of δ-aminolaevulinic acid synthase in liver mitochondria induced by feeding of 3,5-dicarbethoxy-1,4-dihydro-collidine (1963) J. Biol. Chem., 238, pp. 821-827 | ||
| 504 | |a Greenstein, L.R., Hitt, B.A., Mazze, R.I., Metabolism in vitro of Enflurane, Isoflurane and Methoxyflurane (1975) Anesthesiology, 42, pp. 420-424 | ||
| 504 | |a Habig, W.H., Pabst, M.J., Jakoby, W.B., Glutatione S-transferases (1974) J. Biol. Chem., 249, pp. 7130-7139 | ||
| 504 | |a Hitt, B.A., Mazze, R.I., Stevens, W.C., White, A., Eger E.I. II, Species, strain, sex and individual differences in Enflurane metabolism (1975) Br. J. Anaesth., 47, pp. 1157-1161 | ||
| 504 | |a Hitt, B.A., Mazze, R.I., Beppu, W.J., Stevens, W.C., Eger E.I. II, Enflurane metabolism in rats and man (1977) J. Pharmac. Exp. Ther., 203, pp. 193-202 | ||
| 504 | |a Hoffman, J., Konopka, K., Buckhorn, C., Koop, D.R., Waskell, L., Ethanol-inducible cytochrome P450 in rabbits metabolizes enflurane (1989) Br. J. Anaesth, 63, pp. 103-108 | ||
| 504 | |a Honkakoski, P., Kojo, A., Lang, M.A., Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital (1992) Biochem. J., 285, pp. 979-983 | ||
| 504 | |a Kharasch, E.D., Thummel, K.E., Identification of cytochrome P-450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane and methoxyflurane (1993) Anesthesiology, 79, pp. 795-807 | ||
| 504 | |a Kharasch, E.D., Thummel, K.E., Mautz, D., Bosse, S., Clinical Enflurane metabolism by cytochrome P-450 2E1 (1994) Clin. Pharmac. Ther., 55, pp. 434-440 | ||
| 504 | |a Knox, W.E., L-tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rat liver) (1970) Meth. Enzymol., 17, pp. 415-417 | ||
| 504 | |a Larsen, M.C., Brake, P.B., Parlmar, D., Jefcoate, C.R., The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific (1994) Arch. Biochem. Biophys., 315, pp. 24-34 | ||
| 504 | |a Lowry, O., Rosebrough, N., Farr, A., Randall, R., Protein measurement with the folin-phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Marver, H., Tschudy, D., Perlroth, M., Collins, A., δ-Aminolevulinic acid synthetase I. Studies in liver homogenates (1966) J. Biol. Chem., 241, pp. 2803-2809 | ||
| 504 | |a Mauzerall, M., Granick, S., The occurrence and determination of δ-aminolevulinic acid and porphobilinogen in urine (1956) J. Biol. Chem., 219, pp. 435-446 | ||
| 504 | |a Mazze, R.I., Metabolism of the inhaled anaesthetics: Implications of enzyme induction (1984) Br. J. Anaesth., 56, pp. 27S-41S | ||
| 504 | |a Nelson, D.R., Kamataki, T., Waxman, D.J., Guengerich, F.P., Estabrook, R.W., Feyereisen, R., Gonzalez, F.J., Nebert, D.W., The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature (1993) DNA Cell Biol., 12, pp. 1-15 | ||
| 504 | |a Omura, T., Sato, R., The carbon monoxide-binding pigment of liver microsomes (1964) J. Biol. Chem., 239, pp. 2370-2378 | ||
| 504 | |a Plewka, A., Effects of age, phenobarbital, beta-naphthofalvone and dexamethasone on rat hepatic delta-aminolevulinic acid synthase (1995) Arch. Geront. Geriat., 20, pp. 149-158 | ||
| 504 | |a Polo, C.F., Frisardi, A.L., Resnik, E., Schoua, A.E., Del C Batlle, A.M., Factors influencing fluorescence spectra of free porphyrins (1988) Clin. Pharm., 34, pp. 757-760 | ||
| 504 | |a Reinke, L.A., Moyer, M.J., A microsomal oxidation which is highly inducible by ethanol (1985) Drug Metab. Dispos., 13, pp. 548-552 | ||
| 504 | |a Salonpää, P., Krause, K., Pelkonen, O., Raunio, H., Upregulation of CYP2a5 expression by porphyrinogenic agents in mouse liver (1995) Naunyn-schmiedeberg's Arch. Pharmac., 351, pp. 446-452 | ||
| 504 | |a Thummel, K.E., Kharach, E.D., Podoll, T., Kunze, K., Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1 (1993) Drug Metab. Dispos., 21, pp. 350-357 | ||
| 504 | |a Tsutsumi, R., Leo, M.A., Kim, C., Tsutsumi, M., Lasker, J., Lowe, N., Lieber, C.S., Interaction of ethanol with enflurane metabolism and tox-icity: Role of P450IIE1 (1990) Alcohol. Clin. Exp. Res., 14, pp. 174-179 | ||
| 504 | |a Vazquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E., Batlle, A., The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures (1987) Toxicology, 46, pp. 73-82 | ||
| 504 | |a Waxman, D.J., Azaroff, L., Phenobarbital induction of cytochrome P-450 gene expression (1992) Biochem. J., 281, pp. 577-592 | ||
| 504 | |a Yamano, S., Nhamburo, P.T., Aoyama, T., Meyer, U., Inaba, T., Kalow, W., Gelboin, H.V., Gonzalez, F.J., cDNA cloning and sequence and cDNA-directed expression of human P450 IIb1: Identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver (1989) Biochemistry, 28, pp. 7340-7348 | ||
| 504 | |a Ziman, M.R., Bradshaw, J.J., Ivanetich, K.M., The effect of fluoroxene [(2,2,2-trifluoroethoxy)ethane] on heme biosynthesis and degradation (1980) Biochem. J., 190, pp. 571-580 | ||
| 520 | 3 | |a 1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was also enhanced, but these values were lower when animals also received PB. 3. Cytochrome (CYT) P-450 levels were enhanced in animals treated with enflurane whether or not they were given PB. 4. Gluthatione-S-transferase activity was induced by enflurane (138%) or isoflurane (174%), and even more in animals receiving PB also. Sulfatase activity was increased more than 60% with anesthetics. Isoflurane produced a 50% increase of β-glucuronidase activity and a 35% diminution of tryptophan pyrrolase. 5. The association between anesthetics and PB produced diverse effects on the metabolizing enzyme system. 6. Data suggest that both anesthetics, chemically related, could act through two different mechanisms, however, with the same final effect: heme pathway deregulation. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: A. M. Buzaleha ndE . Vazqueaz rea ssociatsec ientifirce searchearsn dA . M. del C. Batlle is superiors cientificr esearcheart the ArgentineN ational Research Council (CONICET). G. Nu~z is a fellows tudentT. his work wass upported by grantsf romt heC ONICET. | ||
| 593 | |a Ctro. Invest. Sobre Porfirinas/P., Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina | ||
| 593 | |a Viamonte 1881 10 A, 1056 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CHRONIC ANESTHESIA |
| 690 | 1 | 0 | |a DRUG-METABOLIZING ENZYME SYSTEM |
| 690 | 1 | 0 | |a ENFLURANE |
| 690 | 1 | 0 | |a HEME METABOLISM |
| 690 | 1 | 0 | |a ISOFLURANE |
| 690 | 1 | 0 | |a 5 AMINOLEVULINATE SYNTHASE |
| 690 | 1 | 0 | |a BETA GLUCURONIDASE |
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a ENFLURANE |
| 690 | 1 | 0 | |a GLUTATHIONE TRANSFERASE |
| 690 | 1 | 0 | |a ISOFLURANE |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a SULFATASE |
| 690 | 1 | 0 | |a TRYPTOPHAN 2,3 DIOXYGENASE |
| 690 | 1 | 0 | |a ANESTHESIA |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a DRUG METABOLISM |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a 5-AMINOLEVULINATE SYNTHETASE |
| 690 | 1 | 0 | |a AMINOLEVULINIC ACID |
| 690 | 1 | 0 | |a ANESTHETICS, INHALATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CYTOCHROME P-450 ENZYME SYSTEM |
| 690 | 1 | 0 | |a ENFLURANE |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a HYPNOTICS AND SEDATIVES |
| 690 | 1 | 0 | |a ISOFLURANE |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a PORPHOBILINOGEN |
| 690 | 1 | 0 | |a PORPHYRINS |
| 700 | 1 | |a Vazquez, E.S. | |
| 700 | 1 | |a Nuñez, G. | |
| 700 | 1 | |a Batlle, A.M.D.C. | |
| 773 | 0 | |d 1997 |g v. 28 |h pp. 577-582 |k n. 4 |p GEN. PHARMACOL. |x 03063623 |w (AR-BaUEN)CENRE-4808 |t General Pharmacology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030961746&doi=10.1016%2fS0306-3623%2896%2900245-5&partnerID=40&md5=ebd532225f573cee86693ca37d4144e5 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0306-3623(96)00245-5 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03063623_v28_n4_p577_Buzaleh |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v28_n4_p577_Buzaleh |y Registro en la Biblioteca Digital |
| 961 | |a paper_03063623_v28_n4_p577_Buzaleh |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 64243 | ||