Features of the shuttle pair 11β-hydroxyprogesterone-11- ketoprogesterone
11β-hydroxyprogesterone (HOP) and 11-ketoprogesterone (KP) are reversible components of a shuttle pair whose interconversion in rat liver is catalyzed by isoform-1 of 11β-hydroxysteroid dehydrogenase. Kidneys also produce this interconversion. The present study was carried out to investigate the shu...
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1997
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| LEADER | 12750caa a22013817a 4500 | ||
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| 001 | PAPER-3289 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203245.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0030952348 | |
| 024 | 7 | |2 cas |a 11-beta-Hydroxysteroid Dehydrogenases, EC 1.1.1.146; 11-hydroxyprogesterone, 312-90-3; 11-ketoprogesterone, 516-15-4; 3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate, 75621-03-3; Cholic Acids; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases, EC 1.1.-; Progesterone, 57-83-0; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Sodium, 7440-23-5; Transcortin, 9010-38-2; Tyrosine Transaminase, EC 2.6.1.5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a STEDA | ||
| 100 | 1 | |a Galigniana, M.D. | |
| 245 | 1 | 0 | |a Features of the shuttle pair 11β-hydroxyprogesterone-11- ketoprogesterone |
| 260 | |c 1997 | ||
| 270 | 1 | 0 | |m Lantos, C.P.; Departamento de Quimica Biologica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Whorwood, C.B., Ricketts, M.L., Stewart, P.M., Epithelial cell localization of type 2 11β-hydroxysteroid dehydrogenase in rat and human colon (1994) Endocrinology, 135, pp. 2533-2541 | ||
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| 504 | |a Galigniana, M., Vicent, G., Lantos, C.P., Burton, G., Ligand properties of 11,19-oxidoprogesterone: A preliminary report (1993) An Asoc Quim Argent, 81, pp. 333-340 | ||
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| 504 | |a McDonnell, D.P., Shabaz, M.M., Vegeto, E., Goldman, M.E., Progesterone receptor A form functions as a transcriptional modelator of mc receptor transcriptional activity (1994) J Steroid Biochem Mol Biol, 48, pp. 425-432 | ||
| 504 | |a Robins, D.M., Scheller, A., Adler, A.J., Specific steroid response from a nonspecific DNA element (1994) J Steroid Biochem Mol Biol, 49, pp. 251-255 | ||
| 504 | |a Rusvai, E., Nàray-Fejes-Tóth, A., A new isoform of 11β-hydroxysteroid dehydrogenase in aldosterone target cells (1993) J Biol Chem, 268, pp. 10717-10720 | ||
| 504 | |a Murphy, B., Cortisol and cortisone in human fetal development (1979) J Steroid Biochem, 11, pp. 509-513 | ||
| 504 | |a Stewart, P.M., Whorwood, C.B., Mason, J.I., Type 2 11β-hydroxysteroid dehydrogenase in fetal and adult life (1995) J Steroid Biochem Mol Biol, 55, pp. 465-471 | ||
| 504 | |a Lantos, C.P., Burton, G., Roldán, A., Damasco, M.C., Aragonés, A., Structure-activity relationship in certain glucocorticoids and miner-alocorticoids (1981) Physiopathology of Endocrine Diseases and Metabolisms of Hormone Action, pp. 477-494. , Soto R, De Nicola A, Blaquier J (eds), Alan R. Liss, New York | ||
| 504 | |a Heap, R.B., Holzbauer, M., Newport, H.M., Adrenal secretion rates of C19 and C21 steroids after hypophysectomy in the pig and the dog (1966) J Endocrinol, 36, pp. 159-176 | ||
| 504 | |a Oertel, G.W., Eik-Nes, K., Isolation and identification of 11-ketoprogesterone, 11-hydroxyprogesterone and 11-hydroxyandrostenedione in canine adrenal vein blood (1962) Endocrinology, 70, pp. 39-42 | ||
| 504 | |a Traikov, H., Birmingham, M.K., Tests for 11β-hydroxyprogesterone and other C-21 steroids (1966) Can J Biochem, 44, pp. 291-292 | ||
| 520 | 3 | |a 11β-hydroxyprogesterone (HOP) and 11-ketoprogesterone (KP) are reversible components of a shuttle pair whose interconversion in rat liver is catalyzed by isoform-1 of 11β-hydroxysteroid dehydrogenase. Kidneys also produce this interconversion. The present study was carried out to investigate the shuttle pair and its components in the rat. As in corticosterone/11 -dehydrocorticosterone, oxidation is more effective at an alkaline pH, while reduction prevails at a neutral pH. Moreover, both reactions are inhibited by the detergent 3-[(3-cholamido propyl)- dimethylammonio]-1-propane-sulphonate (CHAPS). However, at variance with the 11-ketosteroids cortisone (E) and 11-dehydrocorticosterone (A) thought to be 'inactive,' KP has slight direct Na+-retaining properties, and it, as well as HOP, induces glucocorticoids (11β-hydroxycorticoids) to retain sodium. 11-ketoprogesterone exhibits 17 times better affinity for native type I mineralocorticoid receptor than HOP and a 3-fold affinity for partially purified (transcortin free) mineralocorticoid receptor. However, KP, in contrast to HOP, binds only weakly to transcortin, not at all to glucocorticoid receptor, and requires reduction at C11 for tyrosine aminotransferase (TAT) induction. |l eng | |
| 593 | |a Laboratorio de Esteroides, Depto. de Quim. Biológica, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Esteroides, Depto. de Quimica Biológica, Universidad de Buenos Aires, (1428) Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 11Β-HYDROXYPROGESTERONE |
| 690 | 1 | 0 | |a 11Β-HYDROXYSTEROID DEHYDROGENASE |
| 690 | 1 | 0 | |a 11-KETOPROGESTERONE |
| 690 | 1 | 0 | |a SHUTTLE PAIR |
| 690 | 1 | 0 | |a SODIUM RETENTION |
| 690 | 1 | 0 | |a 11BETA HYDROXYPROGESTERONE |
| 690 | 1 | 0 | |a 11BETA HYDROXYSTEROID DEHYDROGENASE |
| 690 | 1 | 0 | |a 3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 1 PROPANESULFONIC ACID |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a DEHYDROCORTICOSTERONE |
| 690 | 1 | 0 | |a MINERALOCORTICOID RECEPTOR |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OXIDATION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a RECEPTOR BINDING |
| 690 | 1 | 0 | |a SHUTTLE VECTOR |
| 690 | 1 | 0 | |a SODIUM RETENTION |
| 690 | 1 | 0 | |a TISSUE SPECIFICITY |
| 690 | 1 | 0 | |a 11-BETA-HYDROXYSTEROID DEHYDROGENASES |
| 690 | 1 | 0 | |a ADRENALECTOMY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BINDING, COMPETITIVE |
| 690 | 1 | 0 | |a CHOLIC ACIDS |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a HYDROGEN-ION CONCENTRATION |
| 690 | 1 | 0 | |a HYDROXYPROGESTERONES |
| 690 | 1 | 0 | |a HYDROXYSTEROID DEHYDROGENASES |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, GLUCOCORTICOID |
| 690 | 1 | 0 | |a RECEPTORS, MINERALOCORTICOID |
| 690 | 1 | 0 | |a SODIUM |
| 690 | 1 | 0 | |a TRANSCORTIN |
| 690 | 1 | 0 | |a TYROSINE TRANSAMINASE |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a HUMULUS |
| 650 | 1 | 7 | |2 spines |a PH |
| 700 | 1 | |a Vicent, G.P. | |
| 700 | 1 | |a Burton, G. | |
| 700 | 1 | |a Lantos, C.P. | |
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