Inhibitory effect of gonadotrophin-releasing hormone (GnRH) on rat granulosa cell deoxyribonucleic acid synthesis
Gonadotropin-releasing hormone (GnRH) has been found to be expressed within the ovary and to modulate cell differentiation in ovarian cells. In the present study we have analyzed the influence of GnRH on DNA synthesis in rat granulosa cells. Cells were obtained from immature DES-treated rats and cul...
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| Formato: | Capítulo de libro |
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John Wiley and Sons Inc.
1997
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10738caa a22009737a 4500 | ||
|---|---|---|---|
| 001 | PAPER-3245 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203243.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-1842293916 | |
| 024 | 7 | |2 cas |a gonadorelin, 33515-09-2, 9034-40-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MREDE | ||
| 100 | 1 | |a Saragüeta, P.E. | |
| 245 | 1 | 0 | |a Inhibitory effect of gonadotrophin-releasing hormone (GnRH) on rat granulosa cell deoxyribonucleic acid synthesis |
| 260 | |b John Wiley and Sons Inc. |c 1997 | ||
| 270 | 1 | 0 | |m Baranao, J.L.; Inst. Medicina/Biologia Experimental, Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Shinohara, O., Knecht, M., Catt, K.J., Inhibition of gonadotropin-induced granulosa cell differentiation by activation of protein kinase C (1985) Proc Natl Acad Sci USA, 82, pp. 8518-8522 | ||
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| 520 | 3 | |a Gonadotropin-releasing hormone (GnRH) has been found to be expressed within the ovary and to modulate cell differentiation in ovarian cells. In the present study we have analyzed the influence of GnRH on DNA synthesis in rat granulosa cells. Cells were obtained from immature DES-treated rats and cultured in defined medium (DMEM:F12) containing combinations of FSH, estradiol, and transforming growth factor-β (TGF-β), both in the presence and absence of GnRH. A GnRH analog, Leuprolide (GnRHa), caused a dose- dependent inhibition of 3H-thymidine incorporation in cells cultured in the presence of FSH (20 ng/ml) and TGFβ (2.5 ng/ml), at concentrations as low as 5 x 10-11 M. Similarly, a complete inhibition of hormonally stimulated DNA synthesis were observed with another analog (Buserelin, ED50 = 1.58 ± 0.22 x 10-10 M) and native GnRH (ED50 = 1.4 ± 0.3 x 10-6 M). A competitive antagonist of GnRH (Antide) was used to neutralize the GnRH agonist effects. Antide 10-8 M could prevent the inhibition elicited by 10-7 M of Leuprolide. These results suggest that GnRH may play a role in the regulation of rat granulosa cell proliferation during follicular development. |l eng | |
| 593 | |a Inst. de Biol. y Med. Exp.-CONICET, Fac. de Ciencias Exactas y Naturales, Buenos Aires, Argentina | ||
| 593 | |a Inst. de Med. y Biol. Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DNA SYNTHESIS |
| 690 | 1 | 0 | |a GONADOTROPIN RELEASING HORMONE |
| 690 | 1 | 0 | |a GRANULOSA CELL |
| 690 | 1 | 0 | |a LHRH |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a GONADORELIN |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a DNA SYNTHESIS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GONADORELIN RELEASE |
| 690 | 1 | 0 | |a GRANULOSA CELL |
| 690 | 1 | 0 | |a GROWTH REGULATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OVARY FOLLICLE DEVELOPMENT |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Lanuza, G.M. | |
| 700 | 1 | |a Barañao, J.L. | |
| 773 | 0 | |d John Wiley and Sons Inc., 1997 |g v. 47 |h pp. 170-174 |k n. 2 |p MOL. REPROD. DEV. |x 1040452X |t Molecular Reproduction and Development | |
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