Lipase-catalyzed monoesterification of 1-O-Hexadecylglycerol in organic solvents

A simple method is presented to esterify 1-O-hexadecyl-rac-glycerol using lipases in different organic solvents. The following fatty acids were used: C(14:0), C(16:0), C(18:0), C(18:1), and C(18:2). Monoesterification was achieved by using a limiting amount of the fatty acid. Both the 1-O- hexadecyl...

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Detalles Bibliográficos
Autor principal: Bertello, L.E
Otros Autores: Salto, M.L, De Lederkremer, R.M
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1997
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
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LEADER 08394caa a22008417a 4500
001 PAPER-3221
003 AR-BaUEN
005 20230518203241.0
008 190411s1997 xx ||||fo|||| 00| 0 eng|d
024 7 |2 scopus  |a 2-s2.0-0030750149 
024 7 |2 cas  |a 1-O-hexadecyl-2-O-hexadecanoylglycerol; 1-O-hexadecyl-3-O-hexadecanoylglycerol, 17810-56-9; chimyl alcohol, 53584-29-5; Fatty Acids; Glycerides; Glyceryl Ethers; Lipase, EC 3.1.1.3; Solvents 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a LPDSA 
100 1 |a Bertello, L.E. 
245 1 0 |a Lipase-catalyzed monoesterification of 1-O-Hexadecylglycerol in organic solvents 
260 |c 1997 
270 1 0 |m De Lederkremer, R.M.; Departamento de Quimica Organica, FCEN, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina; email: lederk@quimor.qo.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a McConville, M.J., Ferguson, M.A.J., The Structure, Biosynthesis and Function of Glycosylated Phosphatidylinositols in the Parasitic Protozoa and Higher Eukaryotes (1993) Biochem. J., 294, pp. 305-324 
504 |a Lederkremer, R.M., Lima, C.E., Ramirez, M.I., Gonçalvez, M.F., Colli, W., Hexadecylpalmitoylglycerol or Ceramide Is Linked to Similar Glycophosphoinositol Anchor-Like Structures in Trypanosoma cruzi (1993) Eur. J. Biochem., 218, pp. 929-936 
504 |a Heise, N., Cardoso De Almeida, M.L., Ferguson, M.A.J., Characterization of the Lipid Moiety of the Glycosylphosphatidylinositol Anchor of Trypanosoma cruzi 1G7-antigen (1995) Molec. Biochem. Parasitol., 70, pp. 71-84 
504 |a Acosta Serrano, A., Schenkman, S., Yoshida, N., Mehlert, A., Richardson, J.M., Ferguson, M.A.J., The Lipid Structure of the Glycosylphosphatidylinositol-Anchored Mucin-Like Sialic Acid Acceptors of Trypanosoma cruzi. Changes during Parasitic Differentiation from Epimastigotes to Infective Metacyclic Trypomastigote Forms (1995) J. Biol. Chem., 270, pp. 27244-27253 
504 |a Bertello, L.E., Gonçalvez, M.F., Colli, W., Lederkremer, R.M., Structural Analysis of Inositol Phospholipids from Trypanosoma cruzi Epimastigote Forms (1995) Biochem. J., 310, pp. 255-261 
504 |a Uhrig, M.L., Couto, A.S., Colli, W., Lederkremer, R.M., Characterization of Inositol Phospholipids in Trypanosoma cruzi Trypomastigote Forms (1996) Biochim. Biophys. Acta, 1300, pp. 233-239 
504 |a Bornscheuer, U.T., Lipase-Catalyzed Syntheses of Monoacylglycerols (1995) Enzyme Microb. Technol., 17, pp. 578-586 
504 |a Kwon, S.J., Han, J.J., Rhee, J.S., Production and in situ Separation of Mono- or Diacylglycerol Catalyzed by Lipases in n-Hexane (1995) Enzyme Microb. Technol., 17, pp. 700-704 
504 |a Meusel, D., Weber, N., Mukherjee, K.D., Stereoselectivity of Lipases: Esterification Reactions of Octadecylglycerol (1992) Chem. Phys. Lipids, 61, pp. 193-198 
504 |a Haraldsson, G.G., Thorarensen, A., The Generation of Glyceryl Ether Lipids Highly Enriched with Eicosapentaenoic Acid and Docosahexaenoic Acid by Lipase (1994) Tetrahedron Lett., 35, pp. 7681-7684 
504 |a Virto, M.D., Agud, I., Montero, S., Blanco, A., Solozabal, R., Lascaray, J.M., Llama, M.J., De Renobales, M., Kinetic Properties of Soluble and Immobilized Candida rugosa Lipase (1995) Appl. Biochem. Biotechnol., 50, pp. 127-136 
504 |a Sjursnes, B.J., Anthonsen, T., Acyl Migration in 1,2-Dibutyrin. Dependence on Solvent and Water Activity (1994) Biocatalysis, 9, pp. 285-297 
504 |a Roberts, W.L., Myher, J.J., Kuksis, A., Rosenberry, T.L., Alkylacylglycerol Molecular Species in the Glycosylinositol Phospholipid Membrane Anchor of Bovine Erythrocyte Acetylcholinesterase (1988) Biochem. Biophys. Res. Commun., 150, pp. 271-277 
504 |a Gubicza, L., Szakács-Schmidt, A., Effects of the Reaction Conditions on the Enantioselective Esterification Using Candida cylindracea Lipase (1994) Biocatalysis, 9, pp. 131-143 
504 |a Miller, C., Austin, H., Posorske, L., Gonzalez, J., Characteristic of an Immobilized Lipase for the Commercial Synthesis of Esters (1988) J. Am. Oil Chem. Soc., 65, pp. 927-931 
504 |a Pastor, E., Otero, C., Ballesteros, A., Enzymatic Preparation of Mono- and Di-Stearin by Glycerolysis of Ethyl Stearate and Direct Esterification of Glycerol in the Presence of a Lipase from Candida antarctica (Novozym 435) (1995) Biocatal. Biotransform., 12, pp. 147-157 
504 |a Chaudhary, S.K., Hernandez, O., A Simplified Procedure for the Preparation of Triphenylmethylethers (1979) Tetrahedron Lett., 2, pp. 95-98 
504 |a Hassner, A., Alexanian, V., Direct Room Temperature Esterification of Carboxylic Acids (1978) Tetrahedron Lett., 46, pp. 4475-4478 
504 |a Ogawa, T., Horisaki, T., Synthesis of 2-O-Hexadecanoyl-1-O-Hexadecyl-[α-Glc-6SO 3Na-(1-6)-α-Glc-(1-6)-α-Glc-(1-3)]-sn-glycerol: A Proposed Structure for the Glyceroglucolipids of Human Gastric Secretion and of the Mucous Barrier of Rat-Stomach Antrum (1983) Carbohydr. Res., 123, pp. C1-C4 
504 |a Subrahmanyam, C., Venkateswara Rao, C., Anjaneyulu, V., Satyanarayana, P., Subba Rao, P.V., Ward, R.S., Pelter, A., New Diterpenes from a New Species of Lobophytum Soft Coral of the South Andaman Coast (1992) Tetrahedron, 48, pp. 3111-3120 
520 3 |a A simple method is presented to esterify 1-O-hexadecyl-rac-glycerol using lipases in different organic solvents. The following fatty acids were used: C(14:0), C(16:0), C(18:0), C(18:1), and C(18:2). Monoesterification was achieved by using a limiting amount of the fatty acid. Both the 1-O- hexadecyl-3-O-acylglycerol and the 2-O-acylglycerol were obtained in a total yield of 75% and a ratio of 7:1 in dichloromethane after 3 d. Chromatographic data for the monoesters, useful for the identification of the natural products, are given (gas-liquid chromatography, thin-layer chromatography, reverse-phase thin-layer chromatography). The structure was confirmed by a chemical synthesis of 1-O-hexadecyl-2-O-hexadecanoylglycerol. The 3-O- glyceride was also formed by acyl migration, as the minor component. The monoesters were separated by column chromatography and characterized by 1H and 13C nuclear magnetic resonance spectra.  |l eng 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas 
536 |a Detalles de la financiación: Universidad de Buenos Aires 
536 |a Detalles de la financiación: This investigation received financial support from UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases, Consejo Nacional de Investiga-ciones Científicas y Técnicas (CONICET) and Universidad de Buenos Aires. 
593 |a CIHIDECAR, Depto. de Quim. Orgánica, Universidad de Buenos Aires, Buenos Aires, Argentina 
593 |a Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428, Buenos Aires, Argentina 
690 1 0 |a CHIMYL ALCOHOL 
690 1 0 |a FATTY ACID 
690 1 0 |a ARTICLE 
690 1 0 |a ESTERIFICATION 
690 1 0 |a NUCLEAR MAGNETIC RESONANCE 
690 1 0 |a REACTION ANALYSIS 
690 1 0 |a STRUCTURE ANALYSIS 
690 1 0 |a CATALYSIS 
690 1 0 |a ESTERIFICATION 
690 1 0 |a FATTY ACIDS 
690 1 0 |a GLYCERIDES 
690 1 0 |a GLYCERYL ETHERS 
690 1 0 |a KINETICS 
690 1 0 |a LIPASE 
690 1 0 |a MAGNETIC RESONANCE SPECTROSCOPY 
690 1 0 |a MOLECULAR STRUCTURE 
690 1 0 |a PSEUDOMONAS 
690 1 0 |a SOLVENTS 
690 1 0 |a TEMPERATURE 
700 1 |a Salto, M.L. 
700 1 |a De Lederkremer, R.M. 
773 0 |d 1997  |g v. 32  |h pp. 907-911  |k n. 8  |p LIPIDS  |x 00244201  |w (AR-BaUEN)CENRE-2318  |t Lipids 
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856 4 0 |u https://doi.org/10.1007/s11745-997-0117-x  |y DOI 
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