Carbon and nitrogen sources regulate δ-aminolevulinic acid and γ-aminobutyric acid transport in Saccharomyces cerevisiae
Evidence has been obtained showing that transport of S-aminolevulinic acid (ALA), a precursor of porphyrin biosynthesis in Saccharomyces cerevisiae, is mediated by the γ-aminobutyric acid (GABA)-specific permease, UGA4. In yeast GABA is also incorporated by the general amino acid permease (GAP1) and...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1997
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09264caa a22009737a 4500 | ||
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| 001 | PAPER-3209 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203241.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0343907156 | |
| 024 | 7 | |2 cas |a Aminolevulinic Acid, 106-60-5; Carbon, 7440-44-0; Culture Media; GABA permease, 69913-01-5; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid, 56-12-2; Membrane Transport Proteins; Nitrogen, 7727-37-9; Organic Anion Transporters; Proline, 147-85-3; Quaternary Ammonium Compounds; Saccharomyces cerevisiae Proteins; UGA4 protein, S cerevisiae; Urea, 57-13-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IJBBF | ||
| 100 | 1 | |a Garcí, S.C. | |
| 245 | 1 | 0 | |a Carbon and nitrogen sources regulate δ-aminolevulinic acid and γ-aminobutyric acid transport in Saccharomyces cerevisiae |
| 260 | |c 1997 | ||
| 270 | 1 | 0 | |m Batlle, A.Viamonte 1881, 1056 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Bermúdez Moretti, M., Correa García, S., Stella, C., Ramos, E., Batlle, A., δ-aminolevulinic acid transport in saccharomyces cerevisiae (1993) International Journal of Biochemistry, 25, pp. 1917-1924 | ||
| 504 | |a Bermúdez Moretti, M., Correa García, S., Chianelli, M., Ramos, E., Mattoon, J., Batlle, A., Evidence that 4-aminobutyric acid and 5-aminolevulinic acid share a common transport system into Saccharomyces cerevisiae (1995) International Journal of Biochemistry and Cell Biology, 27, pp. 169-173 | ||
| 504 | |a Bermúdez Moretti, M., Correa García, S., Ramos, E., Batlle, A., GABA uptake in a Saccharomyces cerevisiae strain (1995) Cellular and Molecular Biology, 41, pp. 843-849 | ||
| 504 | |a Bermúdez Moretti, M., Correa García, S., Ramos, E., Batlle, A., δ-aminolevulinic acid uptake is mediated by the γ-aminobutyric acid-specific permease UGA4 (1996) Cellular and Molecular Biology, 42, pp. 519-524 | ||
| 504 | |a Correa García, S., Bermúdez Moretti, M., Cardalda, C., Rossetti, M.V., Batlle, A., The role of ALA-S and ALA-D in regulating porphyrin biosynthesis in a normal and a Hem R + mutant strain of Saccharomyces cerevisiae (1993) Yeast, 9, pp. 165-173 | ||
| 504 | |a Grenson, M., Amino acid transporters in yeast: Structure, function and regulation (1992) Molecular Aspects of Transport Proteins, pp. 219-245. , Elsevier Science, Amsterdam | ||
| 504 | |a Grenson, M., Hou, C., Crabeel, P., Multiplicity of the amino acid permease in Saccharomyces cerevisiae. IV. Evidence for a general amino acid permease (1970) Journal of Bacteriology, 103, pp. 770-777 | ||
| 504 | |a Grenson, M., Muyldermans, F., Broman, K., Vissers, S., 4-aminobutyric acid (GABA) uptake in baker's yeast Saccharomyces cerevisiae is mediated by the general amino acid permease, the proline permease and a specific permease integrated into the GABA-catabolic pathway (1987) Biochemistry (Life Sciences Adv.), 6, pp. 35-39 | ||
| 504 | |a Jacobs, P., Jauniaux, J.-C., Grenson, M., A cis-dominant regulatory mutation linked to the argB-argC gene cluster in Saccharomyces cerevisiae (1980) Journal of Molecular Biology, 139, pp. 691-704 | ||
| 504 | |a Magasanik, B., Regulation of nitrogen utilization (1992) The Molecular and Cellular Biology of the Yeast Saccharomyces, 2, pp. 283-317. , Cold Spring Harbor Laboratory Press, U.S.A | ||
| 504 | |a Mattoon, J.R., Malamud, D.R., Brunner, A., Braz, G., Carvajal, E., Lancashire, W.E., Panek, A.D., Regulation of heme formation and cytochrome biosynthesis in normal and mutant yeast (1978) Biochemistry and Genetics of Yeast. Pure and Applied Aspects, pp. 317-337. , Edited by Bacilla M., Horecker B. and Stoppani A. O. M., Academic Press, New York | ||
| 504 | |a McKelvey, J., Rai, R., Cooper, T.G., GABA transport in Saccharomyces cerevisiae (1990) Yeast, 6, pp. 263-270 | ||
| 504 | |a Pietruzsko, R., Fowden, L., 4-aminobutyric acid metabolism in plants. I. Metabolism in yeast (1961) Annals of Botany, 25, pp. 491-511 | ||
| 504 | |a Ramos, F., El Guezzar, M., Grenson, M., Wiame, J.-M., Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae (1985) European Journal of Biochemistry, 149, pp. 401-404 | ||
| 504 | |a Vissers, S., André, B., Muyldermans, F., Grenson, M., Positive and negative regulatory elements control the expression of UGA4 gene coding for the inducible 4-aminobutyric acid-specific permease in Saccharomyces cerevisiae (1989) European Journal of Biochemistry, 181, pp. 357-361 | ||
| 504 | |a Wills, C., Regulation of sugar and ethanol metabolism in Saccharomyces cerevisiae (1990) Biochemical Molecular Biology, 25, pp. 245-280 | ||
| 504 | |a Woods, R., Sanders, H., Briquet, M., Foury, F., Drysdale, B., Mattoon, J.R., Regulation of mitochondrial biogenesis. Enzymatic changes in cytochrome-deficient yeast mutants requiring δ-aminolevulinic acid (1975) Journal of Biological Chemistry, 250, pp. 9090-9098 | ||
| 504 | |a Yeung Laiwah, A., Moore, M., Goldberg, A., Pathogenesis of acute porphyria (1987) Quartely Journal of Medicine-New Series, 63, pp. 377-392 | ||
| 520 | 3 | |a Evidence has been obtained showing that transport of S-aminolevulinic acid (ALA), a precursor of porphyrin biosynthesis in Saccharomyces cerevisiae, is mediated by the γ-aminobutyric acid (GABA)-specific permease, UGA4. In yeast GABA is also incorporated by the general amino acid permease (GAP1) and the specific proline permease (PUT4). The aim of the present work was to carry out a comparative study on the regulation of ALA and GABA transport to confirm our proposal that both compounds share the UGA4 permease. ALA and GABA uptake were measured in cells grown on minimal media with different carbon and/or nitrogen sources. To study the effect of the carbon source on UGA4 permease, ALA and GABA incorporation mere measured in D27 strain, lacking GAP1 permease, and grown in proline as the sole nitrogen source, so the activity of PUT4 permease was negligible. The effect of the nitrogen source on UGA4 permease was studied measuring ALA and GABA uptake rates in cells from media with ammonium, proline and urea as nitrogen sources. It was found that the regulation by the carbon source was similar on ALA and GABA transport; they depend equally on the energetic conditions of the cells. Moreover, regulation by the nitrogen source on ALA and GABA uptake was also similar, and identical to that described already for UGA4 permease. These results are further evidence that both compounds, ALA and GABA, share the GABA-specific permease, UGA4. |l eng | |
| 536 | |a Detalles de la financiación: National Council for Scientific Research | ||
| 536 | |a Detalles de la financiación: from the Argentine National Research Council (CON-ICET). We thank Prof. Dr James Mattoon (U.S.A.) and Prof. Dr Marcelle Grenson and Prof. Dr Stephan Vissers (Belgium) for kindly providing several yeast strains. | ||
| 593 | |a Ctro. de Invest. Sobre Porfirinas P., Ciudad Universitaria, Pabellón II, 2o Piso, 1428 Buenos Aires, Argentina | ||
| 593 | |a Departimento. de Bioquim., Facultad de Medicina, UBA, Paraguay 2155, 5o Piso, 1121 Buenos Aires, Argentina | ||
| 593 | |a Viamonte 1881, 1056 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ALA |
| 690 | 1 | 0 | |a GABA |
| 690 | 1 | 0 | |a SACCHAROMYCES CEREVISIAE |
| 690 | 1 | 0 | |a TRANSPORT REGULATION |
| 690 | 1 | 0 | |a UGA4 PERMEASE |
| 690 | 1 | 0 | |a 4 AMINOBUTYRIC ACID |
| 690 | 1 | 0 | |a AMINOLEVULINIC ACID |
| 690 | 1 | 0 | |a NITROGEN |
| 690 | 1 | 0 | |a PERMEASE |
| 690 | 1 | 0 | |a 4 AMINOBUTYRIC ACID UPTAKE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a SACCHAROMYCES CEREVISIAE |
| 690 | 1 | 0 | |a AMINOLEVULINIC ACID |
| 690 | 1 | 0 | |a BIOLOGICAL TRANSPORT |
| 690 | 1 | 0 | |a CULTURE MEDIA |
| 690 | 1 | 0 | |a GABA PLASMA MEMBRANE TRANSPORT PROTEINS |
| 690 | 1 | 0 | |a GAMMA-AMINOBUTYRIC ACID |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a MEMBRANE TRANSPORT PROTEINS |
| 690 | 1 | 0 | |a NITROGEN |
| 690 | 1 | 0 | |a ORGANIC ANION TRANSPORTERS |
| 690 | 1 | 0 | |a PROLINE |
| 690 | 1 | 0 | |a QUATERNARY AMMONIUM COMPOUNDS |
| 690 | 1 | 0 | |a SACCHAROMYCES CEREVISIAE |
| 690 | 1 | 0 | |a SACCHAROMYCES CEREVISIAE PROTEINS |
| 690 | 1 | 0 | |a UREA |
| 690 | 1 | 0 | |a SACCHAROMYCES CEREVISIAE |
| 650 | 1 | 7 | |2 spines |a CARBON |
| 650 | 1 | 7 | |2 spines |a CARBON |
| 700 | 1 | |a Moretti, M.B. | |
| 700 | 1 | |a Ramos, E. | |
| 700 | 1 | |a Batlle, A. | |
| 773 | 0 | |d 1997 |g v. 29 |h pp. 1097-1101 |k n. 8-9 |p INT. J. BIOCHEM. CELL BIOL. |x 13572725 |w (AR-BaUEN)CENRE-5218 |t International Journal of Biochemistry and Cell Biology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_13572725_v29_n8-9_p1097_Garci |y Handle |
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| 999 | |c 64162 | ||