Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal
1. Male CF 1 mice were fed p-dimethylaminoazobenzene (DAB) for 35 days and received 5,5 diethylbarbituric acid, before or after DAB treatment, with the purpose of investigating whether the onset of the preinitiation stage of carcinogenesis alters the natural regulatory mechanism of the heme pathway....
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| Otros Autores: | , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1997
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 09258caa a22009737a 4500 | ||
|---|---|---|---|
| 001 | PAPER-3174 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203238.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0030879634 | |
| 024 | 7 | |2 cas |a 4 dimethylaminoazobenzene, 60-11-7; 5 aminolevulinate synthase, 9037-14-3; barbital, 144-02-5, 57-44-3; cytochrome P450, 9035-51-2; heme oxygenase, 9059-22-7 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a GEPHD | ||
| 100 | 1 | |a Gerez, E. | |
| 245 | 1 | 0 | |a Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal |
| 260 | |c 1997 | ||
| 270 | 1 | 0 | |m Batlle, A.Viamonte 1881 10 'A', 1056 Beunos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Aström, A., De Pierre, J., Eriksson, L., Characterization of drug metabolizing systems in hyper-plastic nodules from the livers of rats receiving 2-acetylaminofluorene in their diet (1983) Carcinogenesis (Lond.), 4, pp. 577-581 | ||
| 504 | |a Brady, A., Hasmall, R., Elcombe, B., Comparison of the effects of griseofulvin and dihydropyridines on ferrochelatase mouse and rat hepatocytes (1993) Toxicol. in Vitro, 7, pp. 587-593 | ||
| 504 | |a Cameron, R., Sweeney, G., Jones, K., Lee, G., Farber, E., A relative deficiency of cytochrome P450 and aryl hydrocarbonbenzo (α) pyrene hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver (1976) Cancer Res., 36, pp. 3888-3893 | ||
| 504 | |a Chance, B., Maehly, A., Assay of catalases and peroxidases (1955) Methods in Enzymology Vol. 2, pp. 764-768. , E. Chance, & A. Maehly. New York: Academic Press | ||
| 504 | |a El-Mouelhi, M., Didolkar, M., Elias, E., Guengerich, F., Kauffman, F., Hepatic drug metabolizing enzymes in primary and secondary tumors of human liver (1987) Cancer Res., 47, pp. 460-466 | ||
| 504 | |a Farber, E., Cellular biochemistry of the stepwise development of cancer with chemicals: G.H.A. Clowes Memorial Lectures (1984) Cancer Res., 44, pp. 5463-5474 | ||
| 504 | |a Gindi, T., Ghazarian, D., Deitch, D., Farber, E., An origin of presumptive preneoplastic foci and nodules from hepatocytes in chemical carcinogenesis in rat liver (1994) Cancer Lett., 83, pp. 75-80 | ||
| 504 | |a Habib, S., Srikanth, N., Scappaticci, F., Faletto, M., MacCulbin, A., Farber, E., Ghoshal, A., Gurtoo, H., Altered expression of cytochrome P450 mRNA during chemical-induced hepatocarcinogenesis and following partial hepatectomy (1994) Toxicol. Appl. Pharmacol., 124, pp. 139-148 | ||
| 504 | |a Habig, W., Pabst, M., Jakoby, W., Glutathione-S-transferases: The first enzymatic step in mercapturic acid formation (1974) J. Biol. Chem., 249, pp. 7130-7139 | ||
| 504 | |a Harrison, D., Molecular mechanism of drug resistance in tumors (1995) J. Pathol., 175, pp. 7-12 | ||
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| 504 | |a Kitagawa, T., Pitot, H., Miller, E., Miller, J., Promotion by dietary phenobarbital of hepatocarcinogenesis by 2-methyl-N,N-dimethyl-4-aminoazobenzene in the rat (1979) Cancer Res., 39, pp. 112-115 | ||
| 504 | |a Knox, W., L-Tryptophan 2,3-dioxygenase (trytophanpyrrolase) (rat liver) (1970) Methods Enzymol., 17, pp. 415-417 | ||
| 504 | |a Lowry, O., Rosebrough, N., Farr, A., Randall, R., Protein measurement with the Folin-phenol reagent (1951) J. Biol Chem., 193, pp. 265-275 | ||
| 504 | |a Marver, H., Tschudy, D., Perlroth, M., Collins, A., δ-Aminolevulinic acid synthetase I: Studies in liver homogenates (1966) J. Biol. Chem., 241, pp. 2803-2809 | ||
| 504 | |a Miller, E., Miller, J., The metabolism of chemical carcinogens to reactive electrophiles and their possible mechanism of action in carcinogenesis (1976) Chemical Carcinogens, pp. 737-762. , C.E. Searle. Washington DC: American Chemical Society | ||
| 504 | |a Omura, T., Sato, R., The carbon monoxide binding pigment of liver microsomes (1964) J. Biol. Chem., 239, pp. 2370-2378 | ||
| 504 | |a Peraino, C., Fry, R., Staffeldt, E., Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene (1971) Cancer Res., 31, pp. 1506-1512 | ||
| 504 | |a Polo, C., Vazquez, E., Caballero, F., Gerez, E., Batlle, A., Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation (1992) Comp. Biochem. Physiol., 103, pp. 251-256 | ||
| 504 | |a Salonpää, P., Krause, K., Pelkonen, O., Up-regulation of CyP2A5 expression by porphyrinogenic agents in mouse liver (1995) Naunyn-Schmideberg's Arch. Pharmac., 351, pp. 446-452 | ||
| 504 | |a Stout, D., Becker, F., Alteration of the ability of liver microsomes to activate N-2-fluorencylacetamide to mutagen of Salmonella thypimurium during hepatocarcinogenesis (1978) Cancer Res., 38, pp. 2274-2278 | ||
| 504 | |a Stout, D., Becker, F., Heme enzyme pattern in rat liver nodules and tumors (1987) Cancer Res., 47, pp. 963-966 | ||
| 504 | |a Tatematsu, M., Tsuda, H., Shibata, M., Masui, T., Asamoto, S., Ito, N., Placental type of glutathione S-transferase (GST-P) as a new marker for hepatocarcinogenesis (1986) Proc. Am. Assoc. Cancer Res. Abstracts, 27, p. 100 | ||
| 504 | |a Toyokuni, S., Okamoto, K., Yodoi, J., Hiai, H., Persistent oxidative stress in cancer (1995) FEBS Letters, 358, pp. 1-3 | ||
| 504 | |a Tredaniel, J., Zalcman, G., Douriez, E., Genes and enzymes involved in carcinogen metabolism (1995) Bull. Cancer, 82, pp. 77-S84 | ||
| 504 | |a Waxman, D., Azaroff, L., Phenobarbital induction of cytochrome P450 gene expression (1992) Biochem. J., 281, pp. 577-592 | ||
| 504 | |a Yoshida, T., Kikuchi, G., Purification and properties of heme oxygenase from pig spleen microsomes (1978) J. Biol. Chem., 253, pp. 4224-4229 | ||
| 520 | 3 | |a 1. Male CF 1 mice were fed p-dimethylaminoazobenzene (DAB) for 35 days and received 5,5 diethylbarbituric acid, before or after DAB treatment, with the purpose of investigating whether the onset of the preinitiation stage of carcinogenesis alters the natural regulatory mechanism of the heme pathway. 2. Changes detected in drug metabolizing enzymes are likely to be the consequence of a primary deregulation mechanism of heme metabolism, shown by an increase in 6 aminolevulinic acid synthetase activity and a decrease in microsomal heme oxygenase, which would finally lead to a great enhancement of cytochrome P450 levels. 3. The alterations found here would give rise to a pattern distinctive to that usually observed in the so called resistant hepatocyte. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Ministerio de Educación y Cultura | ||
| 536 | |a Detalles de la financiación: A. M. del C. Batlle and E. Vazquez hold the posts of Superior and Associate Scientific Researchers and E. Gerez and F. Caballero hold the posts of Researcher Assistant at the Argentine National Research Council (CONICET). The support of CONICET, the University of Buenos Aires and the Ministerio de Educación y Ciencia of Spain is gratefully acknowledged. A. M. del C. Batlle is also grateful to the Association for International Cancer Research (AICR), United Kingdom, for special help. We are indebted to Mrs. Beatriz Corvalán for her skilled technical assistance. To the memory of our beloved César. | ||
| 593 | |a Ctro. Invest. Sobre Porfirinas Y P., (CONICET-FCEN, UBA), Cd. Univ., Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a AZO-DYE |
| 690 | 1 | 0 | |a DRUG METABOLIZING ENZYME SYSTEM |
| 690 | 1 | 0 | |a HEME METABOLISM |
| 690 | 1 | 0 | |a HEPATOCARCINOGENESIS |
| 690 | 1 | 0 | |a PORPHYRINOGEN DRUG |
| 690 | 1 | 0 | |a 4 DIMETHYLAMINOAZOBENZENE |
| 690 | 1 | 0 | |a 5 AMINOLEVULINATE SYNTHASE |
| 690 | 1 | 0 | |a BARBITAL |
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a HEME OXYGENASE |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a HEME SYNTHESIS |
| 690 | 1 | 0 | |a LIVER CARCINOGENESIS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 700 | 1 | |a Vazquez, E. | |
| 700 | 1 | |a Caballero, F. | |
| 700 | 1 | |a Polo, C. | |
| 700 | 1 | |a Batlle, A. | |
| 773 | 0 | |d 1997 |g v. 29 |h pp. 569-573 |k n. 4 |p GEN. PHARMACOL. |x 03063623 |w (AR-BaUEN)CENRE-4808 |t General Pharmacology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/S0306-3623(96)00574-5 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03063623_v29_n4_p569_Gerez |y Handle |
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| 999 | |c 64127 | ||