Synthesis of [131-I]-iodinated quercetin

Two iodination procedures via thallation were applied to quercetin leading to the formation of 2'-iodoquercetin and 2',6,8-triiodoquercetin; their structures being elucidated by FT-IR and NMR spectral analysis. The preparation of mono- and polyiodinated products is discussed here on the ba...

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Autor principal: Barolli, M.G
Otros Autores: Pomilio, A.B
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1997
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
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024 7 |2 cas  |a iodine 131, 10043-66-0, 15124-39-7; quercetin, 117-39-5 
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030 |a JLCRD 
100 1 |a Barolli, M.G. 
245 1 0 |a Synthesis of [131-I]-iodinated quercetin 
260 |c 1997 
270 1 0 |m Pomilio, A.B.; PROPLAME-CONICET, Departamento de Quimica Organica, Facultad Ciencias Exactas Naturales, Pabellon 2, 1428 Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Middleton Jr., E., Kandaswami, C., (1993) The Flavonoids: Advances in Research since 1986, p. 619. , Chapter 15, ed. J.B. Harborne, Chapman and Hall, London 
504 |a Cody, V., Middleton, E., Harborne, J.B., (1986) Plant Flavonoids in Biology and Medicine: Biochemical, Pharmacological and Structure-Activity Relationships, , Alan R. Liss, New York 
504 |a Cody, V., Middleton, E., Harborne, J.B., Beretz, A., (1988) Plant Flavonoids in Biology and Medicine II: Biochemical, Cellular and Medicinal Properties, , Alan R. Liss, New York 
504 |a Lee, T.-P., Matteliano, M.L., Middleton, E., (1982) Life Sci., 31, p. 2765 
504 |a Kato, R., Nakadate, T., Yamamoto, S., Sugimura, T., (1983) Carcinogenesis, 4, p. 1301 
504 |a Lee, P.-C., Shimizu, K., Rossi, T.M., Cumella, J.C., (1988) Pancreas, 3, p. 317 
504 |a Ono, K., Nakane, H., (1990) J. Biochem., 108, p. 609 
504 |a Inouye, Y., Yamaguchi, K., Take, Y., Nakamura, S., (1989) J. Antibiot., 42, p. 1523 
504 |a Das, M., Singh, S.V., Mukhtar, H., Awasthi, Y.C., (1986) Biochem. Biophys. Res. Commun., 141, p. 1170 
504 |a Iio, M., Ono, Y., Kai, S., Fukumoto, M., (1986) J. Nutr. Sci. Vitaminol., 32, p. 635 
504 |a McKillop, A., Hunt, J.D., Zelesko, M.J., Fowler, J.S., Taylor, E.C., McGillivray, G., Kienzle, F., (1971) J. Amer. Chem. Soc., 93, p. 4841 
504 |a Mabry, T.J., Thomas, M.B., (1970) The Systematic Identification of Flavonoids, p. 51. , Springer-Verlag, New York, Heidelberg, Berlin 
520 3 |a Two iodination procedures via thallation were applied to quercetin leading to the formation of 2'-iodoquercetin and 2',6,8-triiodoquercetin; their structures being elucidated by FT-IR and NMR spectral analysis. The preparation of mono- and polyiodinated products is discussed here on the basis of the experimental details and spectral data. This is the first report on the radiolabelling of quercetin, which is here selectively performed with 131-iodine. The radiochemical purity was of 99%.  |l eng 
593 |a Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina 
690 1 0 |a 131-IODINE 
690 1 0 |a 2',6,8- TRIIODOQUERCETIN 
690 1 0 |a 2'-IODOQUERCETIN 
690 1 0 |a IODINATION 
690 1 0 |a QUERCETIN 
690 1 0 |a RADIOLABELLING 
690 1 0 |a IODINE 131 
690 1 0 |a QUERCETIN 
690 1 0 |a ANTIOXIDANT ACTIVITY 
690 1 0 |a ARTICLE 
690 1 0 |a DRUG STRUCTURE 
690 1 0 |a DRUG SYNTHESIS 
690 1 0 |a IODINATION 
690 1 0 |a OXIDATIVE STRESS 
700 1 |a Pomilio, A.B. 
773 0 |d 1997  |g v. 39  |h pp. 927-933  |k n. 11  |p J. LABEL. COMPD. RADIOPHARM.  |x 03624803  |w (AR-BaUEN)CENRE-1949  |t Journal of Labelled Compounds and Radiopharmaceuticals 
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