Differential regulation of putrescine uptake in trypanosoma cruzi and other trypanosomatids
Putrescine uptake in Trypanosoma cruzi epimastigotes is 10 to 50-fold higher than in Leishmania mexicana or Crithidia fasciculata. Polyamine transport in all these trypanosomatids is an energy-dependent process strongly inhibited by the presence of 2,4-dinitrophenol or KCN. Putrescine uptake in T. c...
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1992
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| LEADER | 06077caa a22009497a 4500 | ||
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| 001 | PAPER-311 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518202941.0 | ||
| 008 | 190411s1992 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0026451048 | |
| 024 | 7 | |2 cas |a Eflornithine, 70052-12-9; Putrescine, 110-60-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBRCA | ||
| 100 | 1 | |a Gonzalez, N.S. | |
| 245 | 1 | 0 | |a Differential regulation of putrescine uptake in trypanosoma cruzi and other trypanosomatids |
| 260 | |c 1992 | ||
| 270 | 1 | 0 | |m Gonzalez, N.S.; Instituto de Investigaciones Bioquímicas Fundación Campomar, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, A. Machado 151, 1405 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Pegg, (1986) Biochem. J, 234, pp. 249-262 | ||
| 504 | |a Russell, (1989) The Physiology of Polyamines, 1, pp. 255-279. , U. Bachrach, Y.M. Heimer, 2nd ed, C.R.C. Press Inc, Boca Ratón, FL | ||
| 504 | |a Jänne, Pösö, Raina, (1978) Biochim. Biophys. Acta, 473, pp. 241-293 | ||
| 504 | |a Pegg, (1988) Cancer Res, 48, pp. 759-774 | ||
| 504 | |a Olson, Russell, (1980) Cancer Res, 40, pp. 4373-4380 | ||
| 504 | |a Brandt, Pierce, Fausto, (1972) Biochim. Biophys. Acta, 279, pp. 184-193 | ||
| 504 | |a Sogani, Matsushita, Mueller, Raben, (1972) Biochim. Biophys. Acta, 279, pp. 377-386 | ||
| 504 | |a Oka, Borellini, (1989) Ornithine Decarboxylase: Biology, Enzymology and Molecular Genetics, pp. 7-19. , S. Hayashi, Pergamon Press, New York | ||
| 504 | |a Pohjanpelto, (1976) J. Cell Biol, 68, pp. 512-520 | ||
| 504 | |a Kano, Oka, (1976) J. Biol. Chem, 251, pp. 2795-2800 | ||
| 504 | |a Bethell, Pegg, (1981) J. Cell Physiol, 109, pp. 461-468 | ||
| 504 | |a McCann, Pegg, Sjoerdsma, (1987) Inhibition of Polyamine Metabolism. Biological Significance and Basis for New Therapies, , Academic Press, New York | ||
| 504 | |a Pera, Kramer, Sufrin, Porter, (1986) Cancer Res, 46, pp. 1148-1154 | ||
| 504 | |a Gonzalez, Sánchez, Sferco, Algranati, (1991) Biochem. Biophys. Res. Commun, 180, pp. 797-804 | ||
| 504 | |a Seiler, Dezeure, Polyamine transport in mammalian cells (1990) International Journal of Biochemistry, 20, pp. 211-218 | ||
| 504 | |a Khan, Quemener, Moulinoux, (1991) Cell Biol. Int. Rep, 15, pp. 9-24 | ||
| 504 | |a Ceriani, Gonzalez, Algranati, (1992) FEBS Lett, 301, pp. 261-264 | ||
| 504 | |a Rinehart, Jr., Chen, (1984) J. Biol. Chem, 259, pp. 4750-4756 | ||
| 504 | |a Alhonen-Hongisto, Sëppanen, Jänne, (1980) Biochem. J, 192, pp. 941-945 | ||
| 504 | |a Kakinuma, Hoshino, Igarashi, (1988) Eur. J. Biochem, 176, pp. 409-414 | ||
| 504 | |a Mc Cann, Bacchi, Clarkson, Jr., Seed, Nathan, Amole, Hutner, Sjoerdsma, (1981) Med. Biol, 59, pp. 434-440 | ||
| 504 | |a Balaña Fouce, Escribano, Alunda, (1991) Mol. Cell. Biochem, 107, pp. 127-133 | ||
| 504 | |a Algranati, Sánchez, Gonzalez, (1990) The Biology and Chemistry of Polyamines, pp. 137-146. , S.H. Goldemberg, I.D. Algranati, ICSU-IRL Press, Oxford | ||
| 520 | 3 | |a Putrescine uptake in Trypanosoma cruzi epimastigotes is 10 to 50-fold higher than in Leishmania mexicana or Crithidia fasciculata. Polyamine transport in all these trypanosomatids is an energy-dependent process strongly inhibited by the presence of 2,4-dinitrophenol or KCN. Putrescine uptake in T. cruzi and L. mexicana was markedly decreased by the proton ionophore carbonylcyanide m-chlorophenylhydrazone but it was not affected by ouabain, a Na+-K+ pump inhibitor. The depletion of intracellular polyamines by treatment of parasite cultures with α-difluoromethylornithine elicited a marked induction of putrescine uptake in L. mexicana and C. fasciculata by increasing considerably the Vmax of this process. Conversely, the uptake of putrescine in T. cruzi was essentially unchanged by the same treatment. The differential regulation of putrescine transport in T. cruzi might be related to some distinctive features of polyamine metabolism in this parasite. © 1992. |l eng | |
| 593 | |a Instituto de Investigaciones Bioquímicas Fundación Campomar, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, A. Machado 151, 1405 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 2,4 DINITROPHENOL |
| 690 | 1 | 0 | |a CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE |
| 690 | 1 | 0 | |a POTASSIUM CYANIDE |
| 690 | 1 | 0 | |a PUTRESCINE |
| 690 | 1 | 0 | |a AMINE TRANSPORT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a EPIMASTIGOTE |
| 690 | 1 | 0 | |a LEISHMANIA MEXICANA |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BIOLOGICAL TRANSPORT |
| 690 | 1 | 0 | |a CRITHIDIA FASCICULATA |
| 690 | 1 | 0 | |a EFLORNITHINE |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a LEISHMANIA MEXICANA |
| 690 | 1 | 0 | |a PUTRESCINE |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TEMPERATURE |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a CRITHIDIA FASCICULATA |
| 690 | 1 | 0 | |a LEISHMANIA MEXICANA |
| 690 | 1 | 0 | |a STROPHANTHUS GRATUS |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TRYPANOSOMATIDAE |
| 650 | 1 | 7 | |2 spines |a HOMEOSTASIS |
| 700 | 1 | |a Ceriani, C. | |
| 700 | 1 | |a Algranati, I.D. | |
| 773 | 0 | |d 1992 |g v. 188 |h pp. 120-128 |k n. 1 |p Biochem. Biophys. Res. Commun. |x 0006291X |w (AR-BaUEN)CENRE-905 |t Biochemical and Biophysical Research Communications | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0006-291X(92)92358-5 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0006291X_v188_n1_p120_Gonzalez |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v188_n1_p120_Gonzalez |y Registro en la Biblioteca Digital |
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| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 61264 | ||