Potentiation of the 5-aminolevulinic acid-based photodynamic therapy with cyclophosphamide
We have investigated the efficacy of the Photodynamic Therapy (PDT) from 5-aminolevulinic acid (ALA) in combination with an antineoplastic agent using an in vitro-in vivo model developed in our laboratory. The alkylant cyclophosphamide (CY) was chosen because there is evidence of the porphyrinogenic...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1997
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08512caa a22010217a 4500 | ||
|---|---|---|---|
| 001 | PAPER-3065 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203232.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0343341094 | |
| 024 | 7 | |2 cas |a Aminolevulinic Acid, 106-60-5; Antineoplastic Agents, Alkylating; Cyclophosphamide, 50-18-0; Photosensitizing Agents; Porphyrins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CABCD | ||
| 100 | 1 | |a Casas, A. | |
| 245 | 1 | 0 | |a Potentiation of the 5-aminolevulinic acid-based photodynamic therapy with cyclophosphamide |
| 260 | |c 1997 | ||
| 270 | 1 | 0 | |m Batlle, A.M.D.C.Viamonte 1881 10A, 1056 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Cairnduff, F., Stringer, M.R., Hudson, E.J., Ash, D.V., Brown, S.B., Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer (1994) Br. J. Cancer, 69, pp. 605-608 | ||
| 504 | |a Cowled, P.A., Mackenzie, L., Forbes, I.J., Pharmacological modulation of photodynamic therapy with hematoporphyrin derivative and light (1987) Cancer Res., 47, pp. 971-974 | ||
| 504 | |a Dougherty, T.J., Potter, W.R., Belliner, D., Photodynamic therapy for for the treatment of cancer, current status and advances (1990) Photodynamic Therapy of Neoplastic Disease, pp. 1-19. , D. Kessel (Ed.) CRC Press, Boca Raton, FL | ||
| 504 | |a Falk, J., Porphyrins and metalloporphyrins (1964) Biochim. Biophys. Acta Library, 2. , Elsevier Publishing Company, Amsterdam. London, New York | ||
| 504 | |a Fukuda, H., Paredes, S., Del C. Batlle, A.M., Tumor-localizing properties of porphyrins. In vitro studies using the porphyrin precursor, aminolevulinic acid, in free and liposome encapsulated forms (1989) Drug Des. Deliv., 5, pp. 133-139 | ||
| 504 | |a Fukuda, H., Paredes, S., Casas, A., Chueke, F., Del C. Batlle, A.M., Potential of liposome-entrapped aminolevulinic acid in cancer therapy. Effect of prior injection of empty liposomes and different routes of administration (1992) Cancer J., 5, pp. 295-299 | ||
| 504 | |a Fukuda, H., Paredes, S., Del C. Batlle, A.M., Tumor-localizing properties of porphyrins. In vivo studies using free and liposome encapsulated aminolevulinic acid (1992) Comp. Biochem. Physiol., 2, pp. 433-436 | ||
| 504 | |a Fukuda, H., Casas, A., Chueke, F., Paredes, S., Batlle, A., Photodynamic action of endogenously synthesized porphyrins from aminolevulinic acid, using a new model for assaying the effectiveness of tumoral cell killing (1993) Int. J. Biochem., 25, pp. 1395-1398 | ||
| 504 | |a Jin, M.L., Yang, B.Q., Zhang, W., Ren, P., Combined treatment of photodynamic therapy and chemotherapy for advanced cardiac cancers (1992) J. Photochem, Photobiol. B. Biol., 12, pp. 101-106 | ||
| 504 | |a Kelly, J.F., Snell, M.E., Hematoporphyrin derivative: A possible aid in the diagnosis and therapy of carcinoma of the bladder (1976) J. Urol, 115, pp. 150-157 | ||
| 504 | |a Lipson, R.L., Baldes, E.J., Olsen, A.M., The use of a derivative of hematoporphyrin in tumor detection (1965) J. Natl. Cancer Inst., 26, pp. 1-11 | ||
| 504 | |a Ma, L.W., Moan, J., Steen, H.B., Iani, V., Anti-tumour activity of photodynamic therapy in combination with mitomycin C in nude mice with human colon adenocarcinoma (1995) Br. J. Cancer, 71, pp. 950-956 | ||
| 504 | |a Malik, Z., Lugaci, H., Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins (1987) Br. J. Cancer, 56, pp. 589-595 | ||
| 504 | |a Nahabedian, M.Y., Cohen, R.A., Contino, M.F., Terem, T.M., Wright, W.H., Berns, M.W., Wile, A.G., Combination cytotoxic chemotherapy with cisplatin or doxorubicin and photodynamic therapy in murine tumors (1988) J. Natl. Cancer Inst., 80, pp. 739-743 | ||
| 504 | |a Palma-Carlos, A.G., Palma-Carlos, M.L., Lourenco, M.G., Martins-Silva, J.A., Effect of alkylating agents on haem metabolism (1971) S. Afr. J. Lab, Clin. Med., 25, pp. 81-84 | ||
| 504 | |a Regula, J., Ravi, B., Bedwell, J., MacRobert, A.J., Bown, S.G., Photodynamic therapy using 5-aminolaevulinic acid for experimental pancreatic cancer - Prolonged animal survival (1994) Br. J. Cancer, 70, pp. 248-254 | ||
| 504 | |a Rizzardini, M., Ferraroli, D., Dal Fiume, D., Cantoni, L., Cyclophosphamide-impaired regulation of hepatic heme metabolism (1984) Experientia, 40, pp. 1390-1392 | ||
| 504 | |a Vázquez, E., Afonso, S., Buzaleh, A.M., Navone, N., Polo, C., Schoua, E., Batlle, A., The effect of griseofulvin on the heme pathway Studies on tissue explant cultures (1987) Toxicology, 46, pp. 73-82 | ||
| 504 | |a Wainstok, R., San Martin De Viale, L., Effect of some antineoplasics on metabolic heme pathway (1988) Int. J. Biochem., 20, pp. 1015-1020 | ||
| 520 | 3 | |a We have investigated the efficacy of the Photodynamic Therapy (PDT) from 5-aminolevulinic acid (ALA) in combination with an antineoplastic agent using an in vitro-in vivo model developed in our laboratory. The alkylant cyclophosphamide (CY) was chosen because there is evidence of the porphyrinogenic properties of this drug. Male BALB/c mice bearing a transplantable mammary adenoarcinoma were given two doses of 35 mg de CY/kg wt. i.p. and 9 mg/kg wt intratumorally. At 16, 22 and 40 hrs after the last injection of CY the animals were sacrificed and explants of 2 mg of tumor were incubated 2 hrs in a medium containing 0.6 mM ALA; and then irradiated with a He-Ne laser. Innocula of 1 mm3 of irradiated and nonirradiated tissue were then injected subcutaneously under the right and left flanks of a normal mouse, respectively. The efficacy of the treatment was determined following the growth of the tumor from day 10 after tumor implantation. Under the present conditions a 30% increased efficacy was observed in the case of the explants treated with CY 40 hrs after the last i.p. injection. Porphyrins in the liver and tumor and other tissues of the injected mice were also determined; except for a slight increase in tumor and liver, 40 and 22 hrs after CY i.p. injection respectively, no other changes were observed in any tissue, as compared with not CY treated mice. These results indicate that future treatment, combining the tumor localizing properties of endogenously formed porphyrins from ALA and antineoplasic drugs such as cyclophosphamide, should be encouraged. |l eng | |
| 593 | |a Viamonte 1881 10A, 1056 Buenos Aires, Argentina | ||
| 593 | |a Ctro. Invest. Sobre Porfirinas y P., Ciudad Universitaria, Pabellón II, 1428, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 5-AMINOLEVULINIC ACID |
| 690 | 1 | 0 | |a CYCLOPHOSPHAMIDE |
| 690 | 1 | 0 | |a PHOTODYNAMIC THERAPY |
| 690 | 1 | 0 | |a ALKYLATING AGENT |
| 690 | 1 | 0 | |a AMINOLEVULINIC ACID |
| 690 | 1 | 0 | |a CYCLOPHOSPHAMIDE |
| 690 | 1 | 0 | |a PHOTOSENSITIZING AGENT |
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a ADENOCARCINOMA |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BAGG ALBINO MOUSE |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a CHEMISTRY |
| 690 | 1 | 0 | |a EXPERIMENTAL NEOPLASM |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a MULTIMODALITY CANCER THERAPY |
| 690 | 1 | 0 | |a PHOTOCHEMOTHERAPY |
| 690 | 1 | 0 | |a TIME |
| 690 | 1 | 0 | |a TISSUE DISTRIBUTION |
| 690 | 1 | 0 | |a ADENOCARCINOMA |
| 690 | 1 | 0 | |a AMINOLEVULINIC ACID |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTINEOPLASTIC AGENTS, ALKYLATING |
| 690 | 1 | 0 | |a COMBINED MODALITY THERAPY |
| 690 | 1 | 0 | |a CYCLOPHOSPHAMIDE |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MAMMARY NEOPLASMS, EXPERIMENTAL |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a PHOTOCHEMOTHERAPY |
| 690 | 1 | 0 | |a PHOTOSENSITIZING AGENTS |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a TIME FACTORS |
| 690 | 1 | 0 | |a TISSUE DISTRIBUTION |
| 700 | 1 | |a Fukuda, H. | |
| 700 | 1 | |a Batlle, A.M.D.C. | |
| 773 | 0 | |d 1997 |g v. 16 |h pp. 183-196 |k n. 1 |p Cancer Biochem. Biophys. |x 03057232 |t Cancer Biochemistry Biophysics | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03057232_v16_n1_p183_Casas |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03057232_v16_n1_p183_Casas |y Registro en la Biblioteca Digital |
| 961 | |a paper_03057232_v16_n1_p183_Casas |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 64018 | ||