Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine
The effects of the cyclin-dependent kinase (CDK) inhibitors olomoucine and roscovitine on DNA synthesis were studied using short time incubation (30-90 minutes). Both purine analogues at concentrations from 1-100 μM decreased the DNA synthesis of rat brain cortex in a dose-dependent manner and the m...
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| Formato: | Capítulo de libro |
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Academic Press Inc.
1998
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 05779caa a22008177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2986 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203227.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0032562099 | |
| 024 | 7 | |2 cas |a cyclin dependent kinase, 150428-23-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBRCA | ||
| 100 | 1 | |a Yakisich, J.S. | |
| 245 | 1 | 0 | |a Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine |
| 260 | |b Academic Press Inc. |c 1998 | ||
| 270 | 1 | 0 | |m Yakisich, J.S.; Applied Biochemistry, Clinical Research Center, Huddinge University Hospital, S-141 86 Huddinge, Sweden |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Vesely, J., Havlicek, L., Strnad, M., Blow, J.J., Donella-Deana, A., Pinna, L., Letham, D.S., Meijer, L., (1994) Eur. J. Biochem., 224, pp. 771-786 | ||
| 504 | |a Meijer, L., Borgne, A., Mulner, O., Chong, J.P.J., Blow, J.J., Inagaki, N., Inagaki, M., Moulinoux, J-P., (1997) Eur. J. Biochem., 243, pp. 527-536 | ||
| 504 | |a Glab, N., Labidi, B., Qin, L-X., Trehin, C., Bergounioux, C., Meijer, L., (1994) FEBS Lett., 353, pp. 207-211 | ||
| 504 | |a Abraham, R.T., Acquarone, M., Andersen, A., Asensi, A., Belle, R., Berger, F., Bergounioux, C., Verlhac, M.H., (1995) Biol. Cell., 83, pp. 105-120 | ||
| 504 | |a Meijer, L., (1996) Trends Cell Biol, 6, pp. 393-397 | ||
| 504 | |a Alperin, D.M., Idoyaga-Vargas, V.P., Carminatti, H., (1986) J. Neurochem., 47, pp. 355-362 | ||
| 504 | |a Labarca, C., Paigen, K., (1980) Anal. Biochem., 102, pp. 344-352 | ||
| 504 | |a Nurse, P., Bisset, Y., (1981) Nature, 292, pp. 558-560 | ||
| 504 | |a Gadbois, D.M., Hamaguchi, J.R., Swank, R.A., Bradbury, M.E., (1992) Biochem. Biophys. Res. Comm., 184, pp. 80-85 | ||
| 504 | |a Veerana, S.K.T., Amin, N., Grant, P., Albers, R.W., Pant, H.C., (1996) Neurochem. Res., 21, pp. 629-636 | ||
| 504 | |a Hall, L.L., Th'Ng, J.P.H., Guo, X.W., Teplitz, R.L., Bradbury, M.E., (1996) Cancer Res., 56, pp. 3551-3559 | ||
| 504 | |a Yakisich, J.S., Radrizzani, M., Idoyaga Vargas, V., (1994) Neurosci. Lett., 180, pp. 17-20 | ||
| 504 | |a Blow, J.J., Laskey, R.A., (1988) Nature, 332, pp. 546-548 | ||
| 504 | |a Chong, J.P.J., Mahbubani, H.M., Khoo, C-Y., Blow, J.J., (1995) Nature, 375, pp. 418-421 | ||
| 504 | |a Shields, R., (1977) Nature, 267, pp. 704-707 | ||
| 504 | |a McAuley, A., Werb, Z., Mirkes, P.E., (1993) Development, 117, pp. 873-883 | ||
| 504 | |a Weinert, T.A., Hartwell, L.H., (1988) Science, 241, pp. 317-322 | ||
| 504 | |a Hartwell, L.H., Weinert, T.A., (1989) Science, 246, pp. 629-634 | ||
| 504 | |a Hartwell, L.H., Kastan, M.B., (1994) Science, 266, pp. 1821-1828 | ||
| 520 | 3 | |a The effects of the cyclin-dependent kinase (CDK) inhibitors olomoucine and roscovitine on DNA synthesis were studied using short time incubation (30-90 minutes). Both purine analogues at concentrations from 1-100 μM decreased the DNA synthesis of rat brain cortex in a dose-dependent manner and the maximum effect occurred within 30 min of incubation. Staurosporine, another potent CDK inhibitor did not affect the DNA synthesis in the concentration range 1-250 nM. These results indicate that olomoucine and roscovitine block DNA synthesis by a mechanism independent of CDK inhibition. We propose that the cellullar effects of olomuocine and roscovitine on the cell cycle are at least in part due to this early inhibitory effect on DNA synthesis. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Karolinska Institutet, KI | ||
| 536 | |a Detalles de la financiación: This study was supported by grants from the Karolinska Institute, the Swedish Medical Association and Consejo Nacional de Investi-gaciones CientõB ficas y TeÂcnicas (CONICET) as well as the University of Buenos Aires. The access to resources at the Clinical Research Center, Novum, is gratefully acknowledged. | ||
| 593 | |a Applied Biochemistry, Clinical Research Center, Huddinge University Hospital, S-141 86, Huddinge, Sweden | ||
| 593 | |a Department of Neurology, Karolinska Institute, Huddinge University Hospital, S-141 86, Huddinge, Sweden | ||
| 593 | |a Inst. Invest. Bioquimicas Fund. C., Fac. de Ciencias Exactas y Naturales, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CYCLIN DEPENDENT KINASE |
| 690 | 1 | 0 | |a CYCLIN DEPENDENT KINASE INHIBITOR |
| 690 | 1 | 0 | |a PURINE DERIVATIVE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BRAIN CORTEX |
| 690 | 1 | 0 | |a CELL CYCLE |
| 690 | 1 | 0 | |a DNA SYNTHESIS INHIBITION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a TIME |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Sidén, A. | |
| 700 | 1 | |a Vargas, V.I. | |
| 700 | 1 | |a Eneroth, P. | |
| 700 | 1 | |a Cruz, M. | |
| 773 | 0 | |d Academic Press Inc., 1998 |g v. 243 |h pp. 674-677 |k n. 3 |p Biochem. Biophys. Res. Commun. |x 0006291X |w (AR-BaUEN)CENRE-905 |t Biochemical and Biophysical Research Communications | |
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| 856 | 4 | 0 | |u https://doi.org/10.1006/bbrc.1998.8157 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0006291X_v243_n3_p674_Yakisich |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v243_n3_p674_Yakisich |y Registro en la Biblioteca Digital |
| 961 | |a paper_0006291X_v243_n3_p674_Yakisich |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 63939 | ||