Accurate spatial and temporal transgene expression driven by a 3.8- kilobase promoter of the bovine β-casein gene in the lactating mouse mammary gland
The spatial, temporal, and hormonal pattern of expression of the β- casein gene is highly regulated and confined to the epithelial cells of the lactating mammary gland. Previous studies have shown that 1.7 kb of the bovine β-casein promoter were able to drive cell-specific and hormone- dependent exp...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1998
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 14685caa a22014777a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2984 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203227.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0031937141 | |
| 024 | 7 | |2 cas |a Caseins; Human Growth Hormone, 12629-01-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MREDE | ||
| 100 | 1 | |a Cerdán, M.G. | |
| 245 | 1 | 0 | |a Accurate spatial and temporal transgene expression driven by a 3.8- kilobase promoter of the bovine β-casein gene in the lactating mouse mammary gland |
| 260 | |c 1998 | ||
| 270 | 1 | 0 | |m Rubinstein, M.; INGEBI-CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina; email: mrubins@proteus.dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Zack, D.J., Bennet, J., Wang, Y., Davenport, C., Klaunberg, B., Gearhart, J., Nathans, Unusual topography of bovine rhodopsin promoter-lacZ fusion gene expression in transgenic mouse retinas (1991) Neuron, 6, pp. 187-199 | ||
| 520 | 3 | |a The spatial, temporal, and hormonal pattern of expression of the β- casein gene is highly regulated and confined to the epithelial cells of the lactating mammary gland. Previous studies have shown that 1.7 kb of the bovine β-casein promoter were able to drive cell-specific and hormone- dependent expression to a mouse mammary cell line but failed to induce accurate expression to the mammary gland of transgenic mice. We investigated here the ability of 3.8 kb of the bovine β-casein gene promoter to drive the expression of the human growth hormone (hGH) gene in transgenic mice. A Northern blot analysis using total RNA obtained from different tissues of lactating and nonlactating females revealed the presence of hGH mRNA only in the mammary gland of lactating females. hGH mRNA was not detectable in the mammary gland of virgin females or males. A developmental analysis showed that hGH mRNA only peaked on parturition, resembling more closely the bovine β-casein temporal expression pattern rather than the murine. In situ hibridization studies performed on mammary gland sections showed that the cellular pattern of hGH expression was homogeneous in all lobules from heterozygous and homozygous transgenic mice. Silver grain counts on the tissue sections highly correlated with the hGH contents in the milk determined by radioimmunoassay (r = 0.996). Thus 3.8 kb of the bovine β- casein promoter direct a high-level expression of a reporter gene to the lactating mammary gland of transgenic mice in a tissue-specific and developmentally regulated manner. |l eng | |
| 593 | |a Inst. Invest. Ing. Genet. y Biol. M., Buenos Aires, Argentina | ||
| 593 | |a Depto. de Quim. Biol. FCEyN, Universidad de Buenos Aires, Argentina | ||
| 593 | |a INGEBI-CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CASEIN GENES |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a HUMAN GROWTH HORMONE |
| 690 | 1 | 0 | |a MILK |
| 690 | 1 | 0 | |a TRANSGENIC MICE |
| 690 | 1 | 0 | |a BETA CASEIN |
| 690 | 1 | 0 | |a GROWTH FACTOR |
| 690 | 1 | 0 | |a GROWTH HORMONE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CATTLE |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a MAMMARY GLAND FUNCTION |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NORTHERN BLOTTING |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROMOTER REGION |
| 690 | 1 | 0 | |a RADIOIMMUNOASSAY |
| 690 | 1 | 0 | |a TISSUE SPECIFICITY |
| 690 | 1 | 0 | |a TRANSGENE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CASEINS |
| 690 | 1 | 0 | |a CATTLE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a HUMAN GROWTH HORMONE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MAMMARY GLANDS, ANIMAL |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED C57BL |
| 690 | 1 | 0 | |a MICE, TRANSGENIC |
| 690 | 1 | 0 | |a MILK |
| 690 | 1 | 0 | |a PROMOTER REGIONS (GENETICS) |
| 690 | 1 | 0 | |a TISSUE DISTRIBUTION |
| 690 | 1 | 0 | |a TRANSGENES |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a BOS TAURUS |
| 690 | 1 | 0 | |a BOVINAE |
| 690 | 1 | 0 | |a MURINAE |
| 690 | 1 | 0 | |a MUS MUSCULUS |
| 690 | 1 | 0 | |a RODENTIA |
| 700 | 1 | |a Young, J.I. | |
| 700 | 1 | |a Zino, E. | |
| 700 | 1 | |a Falzone, T.L. | |
| 700 | 1 | |a Otero, V. | |
| 700 | 1 | |a Torres, H.N. | |
| 700 | 1 | |a Rubinstein, M. | |
| 773 | 0 | |d 1998 |g v. 49 |h pp. 236-245 |k n. 3 |p Mol. Reprod. Dev. |x 1040452X |t Molecular Reproduction and Development | |
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