Biosynthesis of progesterone derived neurosteroids by developing avian CNS : In vitro effects on the gabaa receptor complex
It has been demonstrated in different vertebrate species that the GABA(A) receptor complex is modulated by certain steroids. Theses results prompted work on the synthesis of these neurosteroids in the Central Nervous System. However, there are scarcely any studies analyzing their production or their...
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Elsevier Ltd
1998
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 14696caa a22012857a 4500 | ||
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| 003 | AR-BaUEN | ||
| 005 | 20230518203222.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0344301993 | |
| 024 | 7 | |2 cas |a 3beta hydroxy 5beta pregnan 20 one, 128-21-2; carbon 14, 14762-75-5; flunitrazepam, 1622-62-4; pregnanedione, 33041-33-7, 7350-00-7; progesterone, 57-83-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IJDND | ||
| 100 | 1 | |a Pignataro, L. | |
| 245 | 1 | 0 | |a Biosynthesis of progesterone derived neurosteroids by developing avian CNS : In vitro effects on the gabaa receptor complex |
| 260 | |b Elsevier Ltd |c 1998 | ||
| 270 | 1 | 0 | |m De Plazas, S.F.; Instituto de Biologia Celular, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a It has been demonstrated in different vertebrate species that the GABA(A) receptor complex is modulated by certain steroids. Theses results prompted work on the synthesis of these neurosteroids in the Central Nervous System. However, there are scarcely any studies analyzing their production or their modulatory effects on this receptor during development. In this work, the biosynthesis of [C]progesterone metabolites as well as the characterization of their in vitro effects on the GABA(A) receptor complex in developing chick optic lobe were investigated. Studies on progesterone metabolism indicated that this steroid was converted to 5β-pregnanedione, 5β-pregan-3β-ol-20-one, and a 20-hydroxy derivative. Radioactive progesterone was completely metabolized at early embryonic stages, and a great proportion of 5β-pregnanedione was converted to 5β-pregnan-3β-ol-20-one. Thus, it seems that some of the steroidogenic activities present in chick optic lobe are age-dependent, though greater at embryonic stages. Results from in vitro modulation of [H]flunitrazepam binding by 5β-pregnan-3β-ol-20-one indicated that this steroid produces a one-component-concentration dependent enhancement above control binding. 5β-pregnan-3β-ol-20-one EC50 values were 0.195±0.049, 0.101±0.017, 0.147±0.009, and 0.569±0.114 μM, and E(max) were 22.37±1.57, 23.67±4.02, 29.01±1.08, and 15.11±2.67% at embryonic days 11, 14, hatching, and postnatal day 21, respectively.In conclusion, the biosynthesis of 5β-pregnan-3β-ol-20-one from progesterone in developing chick optic lobe, together with its ability to modulate the GABA(A) receptor present in such tissues, suggests a physiological role of this neurosteroid in developing avian Central Nervous System. Copyright (C) 1998 ISDN. Published by Elsevier Science Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from Consejo Nacional de Investigaciones Científicas y Técnicas and Universidad de Buenos Aires. | ||
| 593 | |a Inst. Biol. Cel. y Neurociencias P., Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina | ||
| 593 | |a Inst. de Biol. Y Med. Exp.-CONICET, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Vta. de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CHICK OPTIC LOBE |
| 690 | 1 | 0 | |a DEVELOPING AVIAN CNS |
| 690 | 1 | 0 | |a GABA(A) RECEPTOR COMPLEX |
| 690 | 1 | 0 | |a NEUROSTEROIDOGENESIS |
| 690 | 1 | 0 | |a NEUROSTEROIDS |
| 690 | 1 | 0 | |a [C]PROGESTERONE |
| 690 | 1 | 0 | |a [H]FLUNITRAZEPAM BINDING MODULATION |
| 690 | 1 | 0 | |a 3BETA HYDROXY 5BETA PREGNAN 20 ONE |
| 690 | 1 | 0 | |a 4 AMINOBUTYRIC ACID A RECEPTOR |
| 690 | 1 | 0 | |a CARBON 14 |
| 690 | 1 | 0 | |a FLUNITRAZEPAM |
| 690 | 1 | 0 | |a NEUROSTEROID |
| 690 | 1 | 0 | |a PREGNANEDIONE |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BINDING AFFINITY |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a CENTRAL NERVOUS SYSTEM |
| 690 | 1 | 0 | |a CHICKEN |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EMBRYO |
| 690 | 1 | 0 | |a FOWL |
| 690 | 1 | 0 | |a NERVOUS SYSTEM DEVELOPMENT |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OPTIC LOBE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a STEROID METABOLISM |
| 690 | 1 | 0 | |a STEROIDOGENESIS |
| 700 | 1 | |a Colman Lerner, A.A. | |
| 700 | 1 | |a Barañao, J.L. | |
| 700 | 1 | |a De Plazas, S.F. | |
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