Regulation of follicular luteinization by a gonadotropin-releasing hormone agonist: Relationship between steroidogenesis and apoptosis
The purpose of this study was to evaluate the effects of GnRH-analog (Leuprolide acetate, LA) administration on follicular luteinization in equine chorionic gonadotropin plus human chorionic gonadotropin (eCG + hCG)- superovulated prepubertal treated rats. Results indicate that LA treatment decrease...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1998
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| LEADER | 12811caa a22013217a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2846 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203219.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0031719266 | |
| 024 | 7 | |2 cas |a Fertility Agents, Female; Gonadotropin-Releasing Hormone, 33515-09-2; Leuprolide, 53714-56-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MREDE | ||
| 100 | 1 | |a Andreu, C. | |
| 245 | 1 | 0 | |a Regulation of follicular luteinization by a gonadotropin-releasing hormone agonist: Relationship between steroidogenesis and apoptosis |
| 260 | |c 1998 | ||
| 270 | 1 | 0 | |m Tesone, M.; Inst. de Biologia/Med. Experimental, Obligado 2490, (1428) Buenos Aires, Argentina; email: mtesone@proteus.dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Fraser, H.M., Bouchard, P., Control of the preovulatory luteinizing hormone surge by gonadotropin-releasing hormone antagonists (1994) TEM, 5, pp. 87-93 | ||
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| 504 | |a Lieberman, S., Greenfield, N.J., Wolfson, A., A heuristic proposal for understanding steroidogenic processes (1984) Endocrinol Rev, 5, pp. 128-148 | ||
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| 504 | |a Minaretzis, D., Jakubowski, M., Mortola, J.F., Pavlou, S.N., Gonadotropin-releasing hormone receptor gene expression in human ovary and granulosa-lutein cells (1995) Clin Endocrinol Metab, 80, pp. 430-434 | ||
| 504 | |a Nahum, R., Beyth, Y., Chun, S.-Y., Hsueh, A.J.W., Tsafriri, A., Early onset of deoxyribonucleic acid fragmentation during atresia of preovulatory ovarian follicles in rats (1996) Biol Reprod, 55, pp. 1075-1080 | ||
| 504 | |a Nicosia, S., Diaz, J., Nicosia, R., Saunders, B., Muro-Cacho, C., Cell proliferation and apoptosis during development and aging of the rabbit corpus luteum (1995) Annals Clin Lab Science, 25, pp. 143-157 | ||
| 504 | |a Palumbo, A., Yeh, J., In situ localization of apoptosis in the rat ovary during follicular atresia (1994) Biol Reprod, 51, pp. 888-895 | ||
| 504 | |a Peng, C.H., Fan, N.C., Ligier, M., Vaananen, J., Leung, P.C.K., Expression and regulation of gonadotropin-releasing hormone (GnRH) receptor messenger ribonucleic acids in human granulosaluteal cells (1994) Endocrinology, 135, pp. 1740-1746 | ||
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| 504 | |a Séguin, C., Pelletier, G., Dubé, D., Labrie, F., Distribution of luteinizing hormone-releasing hormone receptors in the rat ovary (1982) Regul Pept, 4, pp. 183-188 | ||
| 504 | |a Smith, C., Richards, J., Yasin, K., Sangster, J., Sridaran, R., Changes in rat luteal ultrastructure and P450Scc content after in vivo treatment with a gonadotropin-releasing hormone agonist (1991) Biol Reprod, 44, pp. 382-391 | ||
| 504 | |a Srivastava, R.K., Krishna, A., Sridaran, R., Follicular development, steroidogenesis and gonadotrophin secretion in response to longterm with a gonadotrophin-releasing hormone agonist in the rat (1995) J Endocrinol, 146, pp. 349-357 | ||
| 504 | |a Stein, P., Bussmann, L., Tesone, M., In vivo regulation of the steroidogenic activity of rat luteal cells by insulin (1995) J Steroid Biochem Molec Biol, 52, pp. 329-335 | ||
| 504 | |a Tesone, M., Ladenheim, R.G., Chiauzzi, V.A., Charreau, E.H., Effect of prolactin on the steroidogenic response of rat luteal cells (1984) Mol Cell Endocrinol, 36, pp. 187-194 | ||
| 504 | |a Tilly, J.L., Billig, H., Kowalski, K.I., Hsueh, A.J.W., Epidermal growth factor and basic fibroblast factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism (1992) Mol Endocrinol, 6, pp. 1942-1950 | ||
| 504 | |a Tilly, J.L., Kowalski, K.I., Johnson, A.L., Hsueh, A.L., Involvement of apoptosis in ovarian follicular atresia and postovulatory regression (1991) Endocrinology, 129, pp. 2799-2801 | ||
| 504 | |a Toaff, M.E., Schleyer, H., Strauss III, J.F., Metabolism of 25-hydroxycholesterol by rat luteal mitochondria and dispersed cells (1982) Endocrinology, 111, pp. 1785-1790 | ||
| 504 | |a Waterman, M.R., Simpson, E.R., Regulation of the biosynthesis of cytochromes P-450 involved in steroid hormone synthesis (1985) Mol Cell Endocrinol, 39, pp. 81-89 | ||
| 504 | |a Whitelaw, P.F., Eidne, K.A., Sellar, R., Smyth, C.D., Hillier, S.E., Gonadotropin-releasing hormone receptor messenger ribonucleic acid expression in the rat ovary (1995) Endocrinology, 136, pp. 172-178 | ||
| 520 | 3 | |a The purpose of this study was to evaluate the effects of GnRH-analog (Leuprolide acetate, LA) administration on follicular luteinization in equine chorionic gonadotropin plus human chorionic gonadotropin (eCG + hCG)- superovulated prepubertal treated rats. Results indicate that LA treatment decreases circulating levels of progesterone (P) and P accumulation in collagenase-dispersed ovarian cell cultures, though estradiol (E2) production is increased. These data suggest that cells from the LA group may be less luteinized following gonadotropin treatment. Studies performed on histological ovarian sections after different times of eCG administration showed that LA injections produce lower amounts of corpora lutea and antral follicles, and a greater number of atretic and preantral follicles. The basal and LH-stimulated P and progestagen accumulations are decreased in incubations of corpora lutea isolated from the LA group. In addition, the mitochondrial cholesterol side-chain cleavage (P450(SCC)) levels in corpora lutea from LA-treated rats are reduced, indicating that the decrease in P production observed is due in part to an alteration in the steroidogenic luteal capability. Immunocytochemical localization of nuclei exhibiting DNA fragmentation by the technique of terminal deoxynucleotidyl transferase end- labeling showed that LA treatment causes an increase in the number of apoptotic cells in preantral and antral follicles at all times studied (1, 2, 4, or 7 days of LA administration). A similar effect, though less pronounced, was observed in corpora lutea. It is concluded that LA treatment produces a failure in the steroidogenic luteal capability and an increase of apoptotic mechanisms in the ovary, producing as a consequence an interference in the follicular recruitment, growth, and luteinization induced by gonadotropins. |l eng | |
| 593 | |a Inst. de Biol. y Med. Experimental, CONICET, Buenos Aires, Argentina | ||
| 593 | |a Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Academia Nacional de Medicina, Buenos Aires, Argentina | ||
| 593 | |a Ctro. de Invest. Endocrinologicas, Buenos Aires, Argentina | ||
| 593 | |a Inst. de Biol. y Med. Experimental, Obligado 2490 (1428), Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a FOLLICULAR LUTEINIZATION |
| 690 | 1 | 0 | |a GNRH-A |
| 690 | 1 | 0 | |a OVARY |
| 690 | 1 | 0 | |a STEROIDOGENESIS |
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN |
| 690 | 1 | 0 | |a EQUINE CHORIONIC GONADOTROPIN |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a GONADORELIN AGONIST |
| 690 | 1 | 0 | |a LEUPRORELIN |
| 690 | 1 | 0 | |a NOVORMON |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL DEATH |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CORPUS LUTEUM FUNCTION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OVARY FOLLICLE DEVELOPMENT |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROGESTERONE BLOOD LEVEL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a STEROIDOGENESIS |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FERTILITY AGENTS, FEMALE |
| 690 | 1 | 0 | |a GONADOTROPIN-RELEASING HORMONE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LEUPROLIDE |
| 690 | 1 | 0 | |a LUTEAL PHASE |
| 690 | 1 | 0 | |a OVARIAN FOLLICLE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a EQUIDAE |
| 653 | 0 | 0 | |a endocorion, elea, Argentina; lupron, abbott, Argentina; novormon, syntex, Argentina |
| 700 | 1 | |a Parborell, F. | |
| 700 | 1 | |a Vanzulli, S. | |
| 700 | 1 | |a Chemes, H. | |
| 700 | 1 | |a Tesone, M. | |
| 773 | 0 | |d 1998 |g v. 51 |h pp. 287-294 |k n. 3 |p Mol. Reprod. Dev. |x 1040452X |t Molecular Reproduction and Development | |
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| 856 | 4 | 0 | |u https://doi.org/10.1002/(SICI)1098-2795(199811)51:3<287::AID-MRD8>3.0.CO;2-L |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_1040452X_v51_n3_p287_Andreu |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1040452X_v51_n3_p287_Andreu |y Registro en la Biblioteca Digital |
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