Dose-dependence of the effects of corticosterone and the non- glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger
Up to now, only glucocorticoids were thought to act on the renal proximal Na+/H+ exchanger. Using fluorimetric techniques we studied the kinetics of Na+/H+ exchange in brush border vesicles from ADX rats treated with increasing doses of corticosterone (B) and 18-hydroxycorticosterone (18OHB). Signif...
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| Otros Autores: | , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Marcel Dekker Inc.
1998
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 05084caa a22007457a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2833 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203218.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0032432299 | |
| 024 | 7 | |2 cas |a 18 hydroxycorticosterone, 561-65-9; adenosine triphosphatase (potassium sodium); corticosterone, 50-22-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ENRSE | ||
| 100 | 1 | |a Igarreta, P. | |
| 245 | 1 | 0 | |a Dose-dependence of the effects of corticosterone and the non- glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger |
| 260 | |b Marcel Dekker Inc. |c 1998 | ||
| 270 | 1 | 0 | |m Igarreta, P.; Lab. de Esteroides, FCEN UBA, Cdad. Universitaria Pab.2, (1428) Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Welbourne, T.C., (1979) Endocrinology, 99, pp. 1071-1079 | ||
| 504 | |a Malnic, G., Ansaldo, M., Lantos, C.P., Damasco, M.C., (1997) Braz J Med Biol Res, 30, pp. 479-486 | ||
| 504 | |a Igarreta, P., Calvo, J.C., Paladini, A.A., Damasco, M.C., (1997) Can J Physiol Pharmacol, 75, pp. 1226-1231 | ||
| 504 | |a Aronson, P.S., (1983) Am J Physiol, 245, pp. 647-659 | ||
| 504 | |a Krisman, C.R., (1962) Analytical Biochemistry, 4, pp. 17-23 | ||
| 504 | |a Schoeneshofer, M., Frenner, A., Dulce, H.J., (1981) J Steroid Biochem, 14, pp. 377-386 | ||
| 504 | |a Sandor, T., Lamourex, J., Lanthier, A., (1964) Steroids, 4, pp. 213-228 | ||
| 504 | |a Borruel, M., Borruel, P., Damasco, M.C., Lantos, C.P., (1974) Gen. Comp. Endocr., 22, pp. 1-12 | ||
| 504 | |a Fraser, R., Lantos, C.P., (1978) J Steroid Biochem, 9, pp. 273-294 | ||
| 504 | |a Feldman, D., Funder, J.W., (1973) Endocrinology, 92, pp. 1389-1396 | ||
| 504 | |a Damasco, M.C., Magarinos, A.M., Lantos, C.P., De Nicola, A.F., (1992) Acta Physiol Pharmacol Latinoam, 42, pp. 27-34 | ||
| 520 | 3 | |a Up to now, only glucocorticoids were thought to act on the renal proximal Na+/H+ exchanger. Using fluorimetric techniques we studied the kinetics of Na+/H+ exchange in brush border vesicles from ADX rats treated with increasing doses of corticosterone (B) and 18-hydroxycorticosterone (18OHB). Significant linear correlations were obtained when the Vmax of each treatment were plotted against log doses. 18OHB exhibits a slightly higher sensitivity than B and log-dose responses were steeper for 18OHB than for B treated rats. Differences between both treatments were highly significant at the 4.8 μg/100 g level, corresponding to the physiological blood level of 18OHB. Physiological doses of both steroids elicited equal Na+/H+ exchange- responses. 18OHB is not a glucocorticoid since even 88μg/100g did not promote hepatic glycogen deposition while the same dose of B increases glycogen deposits 3.5-fold. These results demonstrate the importance of the Na+/H+ exchanger as a mediator between corticoid action and H+ transport and that of the non-glucocorticoid 18OHB in this process. |l eng | |
| 536 | |a Detalles de la financiación: We cordially acknowledge the generous gift of 180HB by Dr Marcel Harnik (The George Wise Faculty of Life Sciences, Tel Aviv University) and we thank Mrs. M. Elisa Otera and Mr Ruben R. Di Paola for technical assistance. The work was supported by CONICET and the University of Buenos Aires. | ||
| 593 | |a Lab. de Esteroides, FCEN UBA, Cdad. Universitaria Pab.2, (1428) Buenos Aires, Argentina | ||
| 593 | |a PRHOM-CONICET, Buenos Aires, Argentina | ||
| 593 | |a IBYME, Buenos Aires, Argentina | ||
| 593 | |a INGEBI, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 18 HYDROXYCORTICOSTERONE |
| 690 | 1 | 0 | |a ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a BRUSH BORDER |
| 690 | 1 | 0 | |a CONFERENCE PAPER |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a FLUOROMETRY |
| 690 | 1 | 0 | |a GLYCOGEN SYNTHESIS |
| 690 | 1 | 0 | |a HORMONE ACTION |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a POTASSIUM TRANSPORT |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTON TRANSPORT |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SODIUM TRANSPORT |
| 690 | 1 | 0 | |a TRANSPORT KINETICS |
| 700 | 1 | |a Lantos, C.P. | |
| 700 | 1 | |a Calvo, J.C. | |
| 700 | 1 | |a Paladini, A.A. | |
| 700 | 1 | |a Damasco, M.C. | |
| 773 | 0 | |d Marcel Dekker Inc., 1998 |g v. 24 |h pp. 601-605 |k n. 3-4 |p Endocr. Res. |x 07435800 |w (AR-BaUEN)CENRE-4569 |t Endocrine Research | |
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| 856 | 4 | 0 | |u https://doi.org/10.3109/07435809809032653 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_07435800_v24_n3-4_p601_Igarreta |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07435800_v24_n3-4_p601_Igarreta |y Registro en la Biblioteca Digital |
| 961 | |a paper_07435800_v24_n3-4_p601_Igarreta |b paper |c PE | ||
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| 999 | |c 63786 | ||