Inhibition of DNA synthesis in human gliomas by roscovitine

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The early effect of 1-100 μM roscovitine, a purine analogue and cyclin- dependent kinase inhibitor, was studied on tissue specimens from eight human malignant gliomas. The tissue was incubated immediately after resection with DMEM containing [3H]methyl-thymidine plus vehicle alone or the proper conc...

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Autor principal: Yakisich, J.S
Otros Autores: Boethius, J., Lindblom, I.O, Wallstedt, L., Vargas, V.I, Sidén, A., Cruz, M.H
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Lippincott Williams and Wilkins 1999
Acceso en línea:Registro en Scopus
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024 7 |2 cas  |a lomustine, 13010-47-4; roscovitine, 186692-46-6 
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100 1 |a Yakisich, J.S. 
245 1 0 |a Inhibition of DNA synthesis in human gliomas by roscovitine 
260 |b Lippincott Williams and Wilkins  |c 1999 
270 1 0 |m Yakisich, J.S.; Department of Neurology, Karolinska Institute, Novum. Huddinge University Hospital, S-141 86 Huddinge, Sweden 
506 |2 openaire  |e Política editorial 
504 |a Kleihues, P., Burger, P.C., Scheithauer, B.W., (1993) Histological Typing of Tumors of the Central Nervous System, , Berlin: Springer-Verlag 
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504 |a Davis, F.G., Freels, S., Grutsch, J., (1998) J Neurosurg, 88, pp. 1-10 
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504 |a Barker, F.G., Chang, S.M., Gutin, P.H., (1998) Neurosurgery, 42, pp. 709-723 
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504 |a Ono, Y., Tamiya, T., Ichikawa, T., (1996) J Neuropathol Exp Neurol, 55, pp. 1026-1031 
504 |a Rollbrocker, B., Waha, A., Louis, D.N., (1996) Acta Neuropathol (Berl), 92, pp. 70-74 
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504 |a Schutte, B., Nieland, L., Van Engeland, M., (1997) Exp Cell Res, 236, pp. 4-15 
504 |a Pippin, J.W., Qu, Q., Meijer, L., (1997) J Clin Lnvest, 100, pp. 2512-2520 
504 |a Yakisich, J.S., Sidén, A., Idoyaga Vargas, V., (1998) Biochem Biophys Res Commun, 243, pp. 674-677 
504 |a Altman, J., Das, G.D., (1996) J Comp Neurol, 126, pp. 337-390 
504 |a Yakisich, J.S., Sidén, A., Idoyaga Vargas, V., (1996) Exp Neurol, 151, pp. 194-202 
504 |a Vilenchik, M.M., Tretjak, T.M., (1977) J Neurochem, 29, pp. 1159-1161 
504 |a Park, D.S., Farinelli, S.E., Greene, L.A., (1996) J Biol Chem, 271, pp. 6161-8169 
504 |a Meijer, L., (1996) Trends Cell Biol, 6, pp. 393-397 
504 |a Abraham, R.T., Acquarone, M., Andersen, A., (1995) Biol Cell, 83, pp. 105-120 
504 |a Dirks, P.B., Rutka, J.T., (1998) Neurosurgery, 40, pp. 1000-1015 
504 |a Maas J.W., Jr., Horstmann, S., Borasio, G.D., (1998) J Neurochem, 70, pp. 1401-1410 
520 3 |a The early effect of 1-100 μM roscovitine, a purine analogue and cyclin- dependent kinase inhibitor, was studied on tissue specimens from eight human malignant gliomas. The tissue was incubated immediately after resection with DMEM containing [3H]methyl-thymidine plus vehicle alone or the proper concentration of roscovitine for 33-90 min. The DNA synthesis rate was assessed by measurement of [3H]methyl-thymidine incorporation into trichloroacetic acid insoluble material/mg protein/min. In all gliomas, 100 μM roscovitine inhibited DNA synthesis by 71-97% (average 89 ± 8%, p < 0.0001). This inhibitory effect of roscovitine appeared within 30 min of incubation and was concentration dependent.  |l eng 
593 |a Applied Biochemistry, Clinical Research Center, Huddinge University Hospital, S-141 86 Huddinge, Sweden 
593 |a Inst. de Invest. Bioquimicas F., FCEyN, UBA, Buenos Aires, Argentina 
593 |a Department of Neurology, Karolinska Institute, Novum, Huddinge University Hospital, S-141 86 Huddinge, Sweden 
690 1 0 |a BRAIN TUMORS 
690 1 0 |a CYCLIN-DEPENDENT KINASES 
690 1 0 |a DNA SYNTHESIS 
690 1 0 |a GLIOMAS 
690 1 0 |a PROLIFERATION RATE 
690 1 0 |a ROSCOVITINE 
690 1 0 |a LOMUSTINE 
690 1 0 |a ROSCOVITINE 
690 1 0 |a ADULT 
690 1 0 |a ARTICLE 
690 1 0 |a CONCENTRATION RESPONSE 
690 1 0 |a DNA SYNTHESIS INHIBITION 
690 1 0 |a DRUG EFFECT 
690 1 0 |a FEMALE 
690 1 0 |a GLIOBLASTOMA 
690 1 0 |a GLIOMA 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN TISSUE 
690 1 0 |a MALE 
690 1 0 |a PRIORITY JOURNAL 
700 1 |a Boethius, J. 
700 1 |a Lindblom, I.O. 
700 1 |a Wallstedt, L. 
700 1 |a Vargas, V.I. 
700 1 |a Sidén, A. 
700 1 |a Cruz, M.H. 
773 0 |d Lippincott Williams and Wilkins, 1999  |g v. 10  |h pp. 2563-2567  |k n. 12  |p NeuroReport  |x 09594965  |w (AR-BaUEN)CENRE-6274  |t NeuroReport 
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856 4 0 |u https://hdl.handle.net/20.500.12110/paper_09594965_v10_n12_p2563_Yakisich  |y Handle 
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