Nitric oxide reduces paracellular resistance in rat thick ascending limbs by increasing Na+ and Cl- permeabilities
About 50% of the Na+ reabsorbed in thick ascending limbs traverses the paracellular pathway. Nitric oxide (NO) reduces the permselectivity of this pathway via cGMP, but its effects on absolute Na+ (PNa +) and Cl- (PCl -) permeabilities are unknown. To address this, we measured the effect of L-argini...
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American Physiological Society
2017
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| LEADER | 15489caa a22016697a 4500 | ||
|---|---|---|---|
| 001 | PAPER-25536 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205736.0 | ||
| 008 | 190410s2017 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85020091657 | |
| 024 | 7 | |2 cas |a chloride, 16887-00-6; nitric oxide, 10102-43-9; sodium, 7440-23-5; arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; cyclic GMP, 7665-99-8; n(g) nitroarginine methyl ester, 50903-99-6; nitric oxide synthase, 125978-95-2; Arginine; Chlorides; Cyclic GMP; Enzyme Inhibitors; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Sodium | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a AJPPF | ||
| 100 | 1 | |a Monzon, C.M. | |
| 245 | 1 | 0 | |a Nitric oxide reduces paracellular resistance in rat thick ascending limbs by increasing Na+ and Cl- permeabilities |
| 260 | |b American Physiological Society |c 2017 | ||
| 270 | 1 | 0 | |m Monzon, C.M.; Case Western Reserve University, Department of Physiology and Biophysics, Robbins E532, 10900 Euclid Ave., MS 4970, United States; email: casandra.monzon@case.edu |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a About 50% of the Na+ reabsorbed in thick ascending limbs traverses the paracellular pathway. Nitric oxide (NO) reduces the permselectivity of this pathway via cGMP, but its effects on absolute Na+ (PNa +) and Cl- (PCl -) permeabilities are unknown. To address this, we measured the effect of L-arginine (0.5 mmol/l; NO synthase substrate) and cGMP (0.5 mmol/l) on PNa + and PCl - calculated from the transepithelial resistance (Rt) and PNa +/PCl - in medullary thick ascending limbs. Rt was 7,722 ± 1,554 ohm·cm in the control period and 6,318 ± 1,757 ohm·cm after L-arginine treatment (P < 0.05). PNa +/PCl - was 2.0 ± 0.2 in the control period and 1.7 ± 0.1 after L-arginine (P < 0.04). Calculated PNa + and PCl - were 3.52 ± 0.2 and 1.81 ± 0.10 × 10-5 cm/s, respectively, in the control period. After L-arginine they were 6.65 ± 0.69 (P < 0.0001 vs. control) and 3.97 ± 0.44 (P < 0.0001) × 10-5 cm/s, respectively. NOS inhibition with Nω-nitro-L-arginine methyl ester (5 mmol/l) prevented L-arginine’s effect on Rt. Next we tested the effect of cGMP. Rt in the control period was 7,592 ± 1,470 and 4,796 ± 847 ohm·cm after dibutyryl-cGMP (0.5 mmol/l; db-cGMP) treatment (P < 0.04). PNa +/PCl - was 1.8 ± 0.1 in the control period and 1.6 ± 0.1 after db-cGMP (P < 0.03). PNa + and PCl - were 4.58 ± 0.80 and 2.66 ± 0.57 × 10-5 cm/s, respectively, for the control period and 9.48 ± 1.63 (P < 0.007) and 6.01 ± 1.05 (P < 0.005) × 10-5 cm/s, respectively, after db-cGMP. We modeled NO’s effect on luminal Na+ concentration along the thick ascending limb. We found that NO’s effect on the paracellular pathway reduces net Na+ reabsorption and that the magnitude of this effect is similar to that due to NO’s inhibition of transcellular transport. © 2017 the American Physiological Society. |l eng | |
| 536 | |a Detalles de la financiación: National Institutes of Health, HL-070985, HL-028982, K01-DK-107787 | ||
| 536 | |a Detalles de la financiación: This work was in part supported by National Institutes of Health Grants HL-028982 and HL-070985 to J. L. Garvin and K01-DK-107787 to R. Occhipinti. | ||
| 593 | |a Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a KIDNEY |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a PARACELLULAR PERMEABILITY |
| 690 | 1 | 0 | |a SODIUM TRANSPORT |
| 690 | 1 | 0 | |a CHLORIDE |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a SODIUM |
| 690 | 1 | 0 | |a ARGININE |
| 690 | 1 | 0 | |a CHLORIDE |
| 690 | 1 | 0 | |a CYCLIC GMP |
| 690 | 1 | 0 | |a ENZYME INHIBITOR |
| 690 | 1 | 0 | |a N(G) NITROARGININE METHYL ESTER |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a NITRIC OXIDE SYNTHASE |
| 690 | 1 | 0 | |a SODIUM |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL MEMBRANE PERMEABILITY |
| 690 | 1 | 0 | |a CONDUCTANCE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ELECTRIC POTENTIAL |
| 690 | 1 | 0 | |a LIMB |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICHAELIS MENTEN KINETICS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OSMOLALITY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a STEADY STATE |
| 690 | 1 | 0 | |a TRANSCYTOSIS |
| 690 | 1 | 0 | |a TRANSEPITHELIAL RESISTANCE |
| 690 | 1 | 0 | |a VELOCITY |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ANTAGONISTS AND INHIBITORS |
| 690 | 1 | 0 | |a BIOLOGICAL MODEL |
| 690 | 1 | 0 | |a DRUG EFFECTS |
| 690 | 1 | 0 | |a HENLE LOOP |
| 690 | 1 | 0 | |a IMPEDANCE |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a KIDNEY TUBULE ABSORPTION |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PERFUSION |
| 690 | 1 | 0 | |a PERMEABILITY |
| 690 | 1 | 0 | |a SPRAGUE DAWLEY RAT |
| 690 | 1 | 0 | |a TRANSPORT AT THE CELLULAR LEVEL |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ARGININE |
| 690 | 1 | 0 | |a BIOLOGICAL TRANSPORT |
| 690 | 1 | 0 | |a CHLORIDES |
| 690 | 1 | 0 | |a CYCLIC GMP |
| 690 | 1 | 0 | |a ELECTRIC IMPEDANCE |
| 690 | 1 | 0 | |a ENZYME INHIBITORS |
| 690 | 1 | 0 | |a IN VITRO TECHNIQUES |
| 690 | 1 | 0 | |a LOOP OF HENLE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MODELS, BIOLOGICAL |
| 690 | 1 | 0 | |a NG-NITROARGININE METHYL ESTER |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a NITRIC OXIDE SYNTHASE |
| 690 | 1 | 0 | |a PERFUSION |
| 690 | 1 | 0 | |a PERMEABILITY |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RENAL REABSORPTION |
| 690 | 1 | 0 | |a SODIUM |
| 700 | 1 | |a Occhipinti, R. | |
| 700 | 1 | |a Pignataro, O.P. | |
| 700 | 1 | |a Garvin, J.L. | |
| 773 | 0 | |d American Physiological Society, 2017 |g v. 312 |h pp. F1035-F1043 |k n. 6 |p Am. J. Physiol. Renal Physiol. |x 03636127 |t American Journal of Physiology - Renal Physiology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1152/ajprenal.00671.2016 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03636127_v312_n6_pF1035_Monzon |y Handle |
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