Modifications of Bordetella bronchiseptica core lipopolysaccharide influence immune response without affecting protective activity
Bordetella bronchiseptica produces respiratory disease primarily in mammals including humans. Although a considerably amount of research has been generated regarding lipopolysaccharide (LPS) role during infection and stimulating innate and adaptive immune response, mechanisms involved in LPS synthes...
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| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier Ltd
2017
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08118caa a22012257a 4500 | ||
|---|---|---|---|
| 001 | PAPER-25531 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205736.0 | ||
| 008 | 190410s2017 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85009064495 | |
| 024 | 7 | |2 cas |a glycosyltransferase, 9033-07-2; Bacterial Proteins; Glycosyltransferases; Lipopolysaccharides | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BMCLE | ||
| 100 | 1 | |a Sisti, F. | |
| 245 | 1 | 0 | |a Modifications of Bordetella bronchiseptica core lipopolysaccharide influence immune response without affecting protective activity |
| 260 | |b Elsevier Ltd |c 2017 | ||
| 270 | 1 | 0 | |m Sisti, F.; Instituto de Biotecnología y Biología Molecular, CCT La Plata CONICET, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calles 49 y 115, Argentina; email: federico@biol.unlp.edu.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Hester, S.E., Park, J., Goodfield, L.L., Feaga, H.A., Preston, A., Harvill, E.T., (2013) BMC Evol Biol, 13, p. 209 | ||
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| 504 | |a Sisti, F., Fernández, J., Higgins, S.C., (2011) Microbiol Immunol, 55, pp. 847-854 | ||
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| 520 | 3 | |a Bordetella bronchiseptica produces respiratory disease primarily in mammals including humans. Although a considerably amount of research has been generated regarding lipopolysaccharide (LPS) role during infection and stimulating innate and adaptive immune response, mechanisms involved in LPS synthesis are still unknown. In this context we searched in B. bronchiseptica genome for putative glycosyltransferases. We found possible genes codifying for enzymes involved in sugar substitution of the LPS structure. We decided to analyse BB3394 to BB3400 genes, closed to a previously described LPS biosynthetic locus in B. pertussis. Particularly, conservation of BB3394 in sequenced B. bronchiseptica genomes suggests the importance of this gene for bacteria normal physiology. Deletion of BB3394 abolished resistance to naive serum as described for other LPS mutants. When purified LPS was analyzed, differences in the LPS core structure were found. Particularly, a GalNA branched sugar substitution in the core was absent in the LPS obtained from BB3394 deletion mutant. Absence of GalNA in core LPS alters immune response in vivo but is able to induce protective response against B. bronchiseptica infection. © 2016 |l eng | |
| 536 | |a Detalles de la financiación: National Science and Technology Development Agency | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported by National Agency for the Promotion of Science and Technology (ANCPyT) grants to D.F.H and AC. A.C., D.F.H., J.F. and F.S. are members of the Scientific Career of CONICET. | ||
| 593 | |a Instituto de Biotecnología y Biología Molecular, CCT La Plata CONICET, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calles 47 y 115, La Plata, 1900, Argentina | ||
| 593 | |a CIHIDECAR, Departamento de Química Orgánica, Facultad de Cs Exactas y Naturales, Universidad de Buenos Aires, Bs. As., 1428, Argentina | ||
| 690 | 1 | 0 | |a BORDETELLA |
| 690 | 1 | 0 | |a GLYCOSYLTRANSFERASE |
| 690 | 1 | 0 | |a LIPOPOLYSACCHARIDE |
| 690 | 1 | 0 | |a BACTERIUM LIPOPOLYSACCHARIDE |
| 690 | 1 | 0 | |a GLYCOSYLTRANSFERASE |
| 690 | 1 | 0 | |a BACTERIAL PROTEIN |
| 690 | 1 | 0 | |a LIPOPOLYSACCHARIDE |
| 690 | 1 | 0 | |a ADAPTIVE IMMUNITY |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BACTERIAL GENE |
| 690 | 1 | 0 | |a BACTERIAL GENOME |
| 690 | 1 | 0 | |a BB3394 GENE |
| 690 | 1 | 0 | |a BB3400 GENE |
| 690 | 1 | 0 | |a BORDETELLA BRONCHISEPTICA |
| 690 | 1 | 0 | |a BORDETELLA BRONCHISEPTICA INFECTION |
| 690 | 1 | 0 | |a CHEMICAL MODIFICATION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DELETION MUTANT |
| 690 | 1 | 0 | |a GENE LOCUS |
| 690 | 1 | 0 | |a GENETIC CONSERVATION |
| 690 | 1 | 0 | |a IMMUNE RESPONSE |
| 690 | 1 | 0 | |a IN VIVO STUDY |
| 690 | 1 | 0 | |a INNATE IMMUNITY |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a BORDETELLA BRONCHISEPTICA |
| 690 | 1 | 0 | |a CHEMISTRY |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a IMMUNE SYSTEM |
| 690 | 1 | 0 | |a IMMUNOLOGY |
| 690 | 1 | 0 | |a MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BACTERIAL PROTEINS |
| 690 | 1 | 0 | |a BORDETELLA BRONCHISEPTICA |
| 690 | 1 | 0 | |a GENES, BACTERIAL |
| 690 | 1 | 0 | |a GLYCOSYLTRANSFERASES |
| 690 | 1 | 0 | |a IMMUNE SYSTEM |
| 690 | 1 | 0 | |a LIPOPOLYSACCHARIDES |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION |
| 700 | 1 | |a Fernández, J. | |
| 700 | 1 | |a Cordero, A. | |
| 700 | 1 | |a Casabuono, A. | |
| 700 | 1 | |a Couto, A. | |
| 700 | 1 | |a Hozbor, D. | |
| 773 | 0 | |d Elsevier Ltd, 2017 |g v. 27 |h pp. 432-436 |k n. 3 |p Bioorg. Med. Chem. Lett. |x 0960894X |w (AR-BaUEN)CENRE-3990 |t Bioorganic and Medicinal Chemistry Letters | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.bmcl.2016.12.049 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0960894X_v27_n3_p432_Sisti |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v27_n3_p432_Sisti |y Registro en la Biblioteca Digital |
| 961 | |a paper_0960894X_v27_n3_p432_Sisti |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 86484 | ||