pH fronts and tissue natural buffer interaction in gene electrotransfer protocols
Gene electrotransfer (GET) protocols, based on the introduction into the cells of genes encoding immunomodulatory molecules, constitute a safe and powerful strategy for inducing an immune response against cancer. But GET efficiency can be significantly affected by damage due to the products of elect...
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Elsevier Ltd
2017
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| LEADER | 13024caa a22010577a 4500 | ||
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| 001 | PAPER-25397 | ||
| 003 | AR-BaUEN | ||
| 005 | 20250625082151.0 | ||
| 008 | 190410s2017 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85030850613 | |
| 030 | |a ELCAA | ||
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Marino, M. | |
| 245 | 1 | 0 | |a pH fronts and tissue natural buffer interaction in gene electrotransfer protocols |
| 260 | |b Elsevier Ltd |c 2017 | ||
| 270 | 1 | 0 | |m Marshall, G.; Consejo Nacional de Investigaciones Científicas y TécnicasArgentina; email: marshalg@retina.ar |
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| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a Gene electrotransfer (GET) protocols, based on the introduction into the cells of genes encoding immunomodulatory molecules, constitute a safe and powerful strategy for inducing an immune response against cancer. But GET efficiency can be significantly affected by damage due to the products of electrolysis, in particular, pH fronts. To elucidate the role of pH fronts and damage in GET efficiency we present an analysis of the pH fronts-tissue natural buffer interaction through a theoretical model using the Nernst-Planck equations for ion transport assuming a tissue with a bicarbonate buffering system and its validation with experimental measurements. pH front-buffer interaction measurements unveil a remarkable behavior tuned by pulse length and frequency: during the ON pulse critical pH front trajectories (pH=8.5 or 5.5) jump forward, during the OFF pulse, they recede due to tissue natural buffer attenuation. Theory shows that they are intimately related to ion transport mode: during the ON pulse, ion transport is mainly governed by migration and trajectories jump forward in time; during the OFF pulse, migration ceases, ion transport is governed solely by diffusion and trajectories recede due to buffer attenuation. Experiments and theory show that regardless of the presence of buffer attenuation, pH fronts remain during several minutes in a non-physiological state after the treatment. These results suggest that regions enclosed by pH fronts trajectories (thus subjected to non-physiological pH values during a sufficiently long time) may be subjected to plasmid damage during a GET treatment. Ways to minimize this effect, thus optimizing GET efficiency are suggested. © 2017 |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: 2014/17 | ||
| 536 | |a Detalles de la financiación: TD 1104 | ||
| 536 | |a Detalles de la financiación: PIP 379/12 | ||
| 536 | |a Detalles de la financiación: M. Marino and F. Maglietti have a scholarship from the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Argentina; N. Olaiz, G. Marshall, and S. Michinski are researchers at CONICET; E. Signori is a researcher at CNR-Rome, Italy. This work was supported by grants from CONICET PIP 379/12, Universidad de Buenos Aires UBACyT 2014/17 and the International European Cooperation in Science and Technology (COST Action TD 1104). E. Signori was partially supported by CNR-Short Term Mobility fellowship 2016. The founders had no role in the study, design, data collection, analysis, decision to publish, or preparation of the manuscript. | ||
| 593 | |a Laboratorio de Sistemas Complejos, Departamento de Computación,Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 593 | |a Instituto de Física del Plasma, Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 593 | |a Laboratory of Molecular Pathology and Experimental Oncology, CNR-IFT, Rome, Italy | ||
| 593 | |a Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina | ||
| 650 | 1 | 7 | |2 spines |a GENES |
| 650 | 1 | 7 | |2 spines |a PH |
| 690 | 1 | 0 | |a ELECTROCHEMOTHERAPY |
| 690 | 1 | 0 | |a ELECTROLYTIC ABLATION |
| 690 | 1 | 0 | |a GENE ELECTROTRANSFER |
| 690 | 1 | 0 | |a IRREVERSIBLE ELECTROPORATION |
| 690 | 1 | 0 | |a PH FRONT TRACKING |
| 690 | 1 | 0 | |a EFFICIENCY |
| 690 | 1 | 0 | |a GENE ENCODING |
| 690 | 1 | 0 | |a IONS |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a TRAJECTORIES |
| 690 | 1 | 0 | |a ELECTROCHEMOTHERAPY |
| 690 | 1 | 0 | |a ELECTROPORATION |
| 690 | 1 | 0 | |a ELECTROTRANSFER |
| 690 | 1 | 0 | |a FRONT TRACKING |
| 690 | 1 | 0 | |a NERNST-PLANCK EQUATIONS |
| 690 | 1 | 0 | |a PHYSIOLOGICAL PH |
| 690 | 1 | 0 | |a PHYSIOLOGICAL STATE |
| 690 | 1 | 0 | |a THEORETICAL MODELING |
| 690 | 1 | 0 | |a TISSUE |
| 700 | 1 | |a Olaiz, N. | |
| 700 | 1 | |a Signori, E. | |
| 700 | 1 | |a Maglietti, F. | |
| 700 | 1 | |a Suárez, C. | |
| 700 | 1 | |a Michinski, S. | |
| 700 | 1 | |a Marshall, Guillermo Ricardo | |
| 773 | 0 | |d Elsevier Ltd, 2017 |g v. 255 |h pp. 463-471 |p Electrochim Acta |x 00134686 |w (AR-BaUEN)CENRE-12 |t Electrochimica Acta | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.electacta.2017.09.021 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00134686_v255_n_p463_Marino |y Handle |
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