VIP induces the decidualization program and conditions the immunoregulation of the implantation process
The decidualization process involves phenotype and functional changes on endometrial cells and the modulation of mediators with immunoregulatory properties as the vasoactive intestinal peptide (VIP). We investigate VIP contribution to the decidualization program and to immunoregulation throughout th...
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| Otros Autores: | , , , , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier Ireland Ltd
2018
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 17314caa a22019097a 4500 | ||
|---|---|---|---|
| 001 | PAPER-25258 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205717.0 | ||
| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85023634349 | |
| 024 | 7 | |2 cas |a dibutyrylcytidine 3',5' phosphate, 64649-87-2; interleukin 8, 114308-91-7; medroxyprogesterone, 520-85-4; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; vasoactive intestinal polypeptide, 37221-79-7; Biomarkers; Culture Media, Conditioned; Vasoactive Intestinal Peptide | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MCEND | ||
| 100 | 1 | |a Grasso, E. | |
| 245 | 1 | 0 | |a VIP induces the decidualization program and conditions the immunoregulation of the implantation process |
| 260 | |b Elsevier Ireland Ltd |c 2018 | ||
| 270 | 1 | 0 | |m Ramhorst, R.; Laboratory of Immunopharmacology, School of Sciences, University of Buenos Aires, IQUIBICEN-CONICET, Int. Guiraldes 2160, Ciudad Universitaria, Pabellón 2 Piso 4, Argentina; email: rramhorst@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The decidualization process involves phenotype and functional changes on endometrial cells and the modulation of mediators with immunoregulatory properties as the vasoactive intestinal peptide (VIP). We investigate VIP contribution to the decidualization program and to immunoregulation throughout the human embryo implantation process. The decidualization of Human endometrial stromal cell line (HESC) with Medroxyprogesterone-dibutyryl-cAMP increased VIP/VPAC-receptors system. In fact, VIP could induce decidualization increasing differentiation markers (IGFBP1, PRL, KLF13/KLF9 ratio, CXCL12, CXCL8 and CCL2) and allowing Blastocyst-like spheroids (BLS) invasion in an in vitro model of embryo implantation. Focus on the tolerogenic effects, decidualized cells induced a semi-mature profile on maternal dendritic cells; restrained CD4+ cells recruitment while increased regulatory T-cells recruitment. Interestingly, the human blastocyst conditioned media from developmentally impaired embryos diminished the invasion and T-regulatory cells recruitment in these settings. These evidences suggest that VIP contributes to the implantation process inducing decidualization, allowing BLS invasion and favoring a tolerogenic micro-environment. © 2017 Elsevier B.V. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBACyT 20020130100040BA, 20020090200034 | ||
| 536 | |a Detalles de la financiación: National Council for Scientific Research, PIP 602/2012-2015 | ||
| 536 | |a Detalles de la financiación: PICT, 2013-1632, 2014-0657 | ||
| 536 | |a Detalles de la financiación: This work was funded by the National Agency of Sciences and Technology ANPCyT (PICT, 2013-1632 and 2014-0657), National Research Council CONICET (PIP 602/2012-2015) and University of Buenos Aires (UBACyT 20020130100040BA and 20020090200034). | ||
| 593 | |a Immunopharmacology Laboratory, School of Sciences, University of Buenos Aires, IQUIBICEN-CONICET, Argentina | ||
| 593 | |a Institute of Experimental Medicine IMEX-CONICET, National Academy of Sciences, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Fertilidad San Isidro, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DECIDUALIZATION |
| 690 | 1 | 0 | |a IMMUNOREGULATION |
| 690 | 1 | 0 | |a IMPLANTATION |
| 690 | 1 | 0 | |a VIP |
| 690 | 1 | 0 | |a CYSTEINE RICH PROTEIN 61 |
| 690 | 1 | 0 | |a DIBUTYRYLCYTIDINE 3',5' PHOSPHATE |
| 690 | 1 | 0 | |a INTERLEUKIN 8 |
| 690 | 1 | 0 | |a MEDROXYPROGESTERONE |
| 690 | 1 | 0 | |a MEMBRANE PROTEIN |
| 690 | 1 | 0 | |a MONOCYTE CHEMOTACTIC PROTEIN 1 |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a PROTEIN KLF13 |
| 690 | 1 | 0 | |a STROMAL CELL DERIVED FACTOR 1 |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a VASOACTIVE INTESTINAL POLYPEPTIDE |
| 690 | 1 | 0 | |a VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR |
| 690 | 1 | 0 | |a BIOLOGICAL MARKER |
| 690 | 1 | 0 | |a VASOACTIVE INTESTINAL POLYPEPTIDE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BLASTOCYST |
| 690 | 1 | 0 | |a CD4+ T LYMPHOCYTE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DECIDUALIZATION |
| 690 | 1 | 0 | |a DENDRITIC CELL |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a IMMUNOREGULATION |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a NIDATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a REGULATORY T LYMPHOCYTE |
| 690 | 1 | 0 | |a STROMAL CELL LINE |
| 690 | 1 | 0 | |a TUMOR SPHEROID |
| 690 | 1 | 0 | |a BIOLOGICAL MODEL |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a CONDITIONED MEDIUM |
| 690 | 1 | 0 | |a CYTOLOGY |
| 690 | 1 | 0 | |a DECIDUA |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a ENDOMETRIUM |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IMMUNOLOGICAL TOLERANCE |
| 690 | 1 | 0 | |a IMMUNOLOGY |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a NIDATION |
| 690 | 1 | 0 | |a PHARMACOLOGY |
| 690 | 1 | 0 | |a STROMA CELL |
| 690 | 1 | 0 | |a TROPHOBLAST |
| 690 | 1 | 0 | |a TUMOR MICROENVIRONMENT |
| 690 | 1 | 0 | |a BIOMARKERS |
| 690 | 1 | 0 | |a BLASTOCYST |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a CELLULAR MICROENVIRONMENT |
| 690 | 1 | 0 | |a CULTURE MEDIA, CONDITIONED |
| 690 | 1 | 0 | |a DECIDUA |
| 690 | 1 | 0 | |a EMBRYO IMPLANTATION |
| 690 | 1 | 0 | |a ENDOMETRIUM |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a IMMUNE TOLERANCE |
| 690 | 1 | 0 | |a MODELS, BIOLOGICAL |
| 690 | 1 | 0 | |a STROMAL CELLS |
| 690 | 1 | 0 | |a TROPHOBLASTS |
| 690 | 1 | 0 | |a VASOACTIVE INTESTINAL PEPTIDE |
| 700 | 1 | |a Gori, S. | |
| 700 | 1 | |a Paparini, D. | |
| 700 | 1 | |a Soczewski, E. | |
| 700 | 1 | |a Fernández, L. | |
| 700 | 1 | |a Gallino, L. | |
| 700 | 1 | |a Salamone, G. | |
| 700 | 1 | |a Martinez, G. | |
| 700 | 1 | |a Irigoyen, M. | |
| 700 | 1 | |a Ruhlmann, C. | |
| 700 | 1 | |a Pérez Leirós, C. | |
| 700 | 1 | |a Ramhorst, R. | |
| 773 | 0 | |d Elsevier Ireland Ltd, 2018 |g v. 460 |h pp. 63-72 |p Mol. Cell. Endocrinol. |x 03037207 |w (AR-BaUEN)CENRE-6138 |t Molecular and Cellular Endocrinology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.mce.2017.07.006 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03037207_v460_n_p63_Grasso |y Handle |
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