MALDI-MS argininyl bufadienolide esters fingerprint from parotoid gland secretions of Rhinella arenarum: Age, gender, and seasonal variation
In many amphibians, the granular glands can be grouped in special regions forming macroglands. This is the case of toads, characterized by the presence of a pair of parotoid macroglands, strategically located to give protection by poison release in case of attacks. The product secreted consists of a...
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| Lenguaje: | Inglés |
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John Wiley and Sons Ltd
2018
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12271caa a22015737a 4500 | ||
|---|---|---|---|
| 001 | PAPER-25192 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205712.0 | ||
| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85048329504 | |
| 024 | 7 | |2 cas |a arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; Arginine; Bufanolides; Esters | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JMSPF | ||
| 100 | 1 | |a Petroselli, G. | |
| 245 | 1 | 0 | |a MALDI-MS argininyl bufadienolide esters fingerprint from parotoid gland secretions of Rhinella arenarum: Age, gender, and seasonal variation |
| 260 | |b John Wiley and Sons Ltd |c 2018 | ||
| 270 | 1 | 0 | |m Petroselli, G.; Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Pabellón II, 3er P., Ciudad Universitaria, Argentina; email: gpetroselli@qo.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Frost, D.R., (2016) Amphibian Species of the World: An Online Reference, , http://research.amnh.org/herpetology/amphibia/index.html, American Museum of Natural History, New York, USA, Version 6.0., Electronic Database accessible at | ||
| 504 | |a Gallardo, J.M., Los anfibios de la Provincia de Entre Ríos, Argentina y algunas notas sobre su distribución geográfica y ecología (1964) Neotropica, 31, pp. 23-38 | ||
| 504 | |a Toledo, L.F., Ribeiro, R.S., Haddad, C.F.B., Anurans as prey: an exploratory analysis and size relationships between predators and their prey (2007) J Zool, 271 (2), pp. 170-177 | ||
| 504 | |a Clarke, B.T., The natural history of amphibian skin secretions, their normal functioning and potential medical applications (1997) Biol Rev, 72 (3), pp. 365-379 | ||
| 504 | |a Sherman, P.J., Jackway, R.J., Nicholson, E., Musgrave, I.F., Boontheung, P., Bowie, J.H., Activities of seasonably variable caerulein and rothein skin peptides from the tree frogs Litoria splendida and Litoria rothii (2009) Toxicon, 54 (6), pp. 828-835 | ||
| 504 | |a Chen, K.K., Jensen, H., Chen, L., The physiological action of the principles isolated from the secretion of Bufo arenarum (1933) JPET, 49, pp. 1-13 | ||
| 504 | |a Rees, R., Schindler, O., Deulofeu, V., Reichstein, T., (1959) Die Bufogenine des Paratoidensekretes von Bufo arenarum Hensel Helvetica, 42, pp. 2400-2418 | ||
| 504 | |a Maciel, N.M., Schwartz, C.A., Rodrigues Pires Júnior, O., Composition of indolealkylamines of Bufo rubescens cutaneous secretions compared to six other Brazilian bufonids with phylogenetic implications (2003) Comp Biochem Physiol B Bioche Mol Biol., 134, pp. 641-649 | ||
| 504 | |a Mebs, D., Wagner, M.G., Pogoda, W., Maneyro, R., Kwet, A., Kauert, G., Lack of bufadienolides in the skin secretion of red bellied toads, Melanophryniscus spp. (Anura, Bufonidae), from Uruguay (2007) Comp Biochem Physiol C Toxicol Pharmacol, 144 (4), pp. 398-402 | ||
| 504 | |a Ferreira, P.M.P., Lima, D.J.B., Debiasi, B.W., Antiproliferative activity of Rhinella marina and Rhaebo guttatus venom extracts from Southern Amazon (2013) Toxicon, 72, pp. 43-51 | ||
| 504 | |a Sciani, J.M., Angeli, C.V., Antoniazzi, M.M., Jared, C., Pimenta, D.C., Differences and similarities among parotoid macrogland secretions in South American toads: a preliminary biochemical delineation (2013) The Scientific World Journal, p. 9. , https://doi.org/10.1155/2013/937407, 9 pages, 2013 | ||
| 504 | |a Rash, L.D., Morales, R.A.V., Vink, S., Alewood, P.F., De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina) (2011) Toxicon, 57 (2), pp. 208-216 | ||
| 504 | |a Mailho-Fontana, P.L., Antoniazzi, M.M., Toledo, L.F., Passive and active defense in toads: the parotoid macroglands in Rhinella marina and Rhaebo guttatus (2014) J. Exp. Zool., 321 A, p. 65 | ||
| 504 | |a Kerkhoff, J., Noronha, J., Bonfilio, R., Quantification of bufadienolides in the poisons of Rhinella marina and Rhaebo guttatus by HPLC-UV (2016) Toxicon, 119, pp. 311-318 | ||
| 504 | |a Schmeda-Hirschmann, G., Quispe, C., Arana, G.V., Theoduloz, C., Urra, F.A., Cárdenas, C., Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae) (2016) Toxicon, 121, pp. 119-129 | ||
| 504 | |a Schmeda-Hirschmann, G., Quispe, C., Theoduloz, C., Teixeira de Sousa, P., Parizotto, C., Antiproliferative activity and new argininyl bufadienolide esters from the “Cururú” toad Rhinella (Bufo) schneideri (2014) J Ethnopharmacol, 155 (2), pp. 1076-1085 | ||
| 504 | |a Sousa-Filho, L.M., Freitas, C.D., Lobo, M.D., Biochemical profile, biological activities, and toxic effects of proteins in the Rhinella schneideri parotoid gland secretion (2016) J Exp Zool A Ecol Genet Physiol, 325 (8), pp. 511-523 | ||
| 504 | |a Nonami, H., Fukui, S., Erra-Balsells, R., β-Carboline alkaloids as matrices for matrix-assisted ultraviolet laser desorption time-of flight mass spectrometry of proteins and sulfated oligosaccharides: a comparative study using phenylcarbonyl compounds, carbazoles and classical matrices (1997) J Mass Spectrom, 32 (3), pp. 287-296 | ||
| 504 | |a Cathers, T., Lewbart, G.A., Correa, M., Stevens, J.B., Serum chemistry and hematology values for anesthetized American bullfrogs (Rana catesbeiana) (1997) J Zoo Wildl Med, 28, p. 171 | ||
| 520 | 3 | |a In many amphibians, the granular glands can be grouped in special regions forming macroglands. This is the case of toads, characterized by the presence of a pair of parotoid macroglands, strategically located to give protection by poison release in case of attacks. The product secreted consists of a wide variety of chemical compounds including proteins, peptides, biogenic amines, toxic steroidal bufadienolides, and various alkaloids, depending on the species. In this work, using Rhinella arenarum, we have performed, for the first time, the matrix assisted-ultraviolet laser desorption/ionization mass spectrometry and tandem mass spectrometry characterization of the components of the secretion used as crude material, just suspended in MeOH (or MeCN). The crude sample as a whole (whole suspension) was spotted on the matrix assisted-ultraviolet laser desorption plate for analysis. Electrospray ionization-Orbitrap was used for cross-checking experiments. The pattern of signals obtained at m/z ranges 600 to 800 and 1200 to 1600 could be assigned as the argininyl bufadienolide esters fingerprint characteristic of female and male. Variation patterns for gender (female, male), age (non-reproductive, reproductive), and season (non-reproductive, reproductive) are described. Copyright © 2018 John Wiley & Sons, Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBACyT X 0055BA, 20020130300007BA | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT 2012‐0888 | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: PIP 11220120100376CO, PIP 0072CO | ||
| 536 | |a Detalles de la financiación: Thermo Scientific, PME2011‐PPL2‐0009 | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, 125, PME2003 | ||
| 536 | |a Detalles de la financiación: The authors are grateful to the University of Buenos Aires (UBACyT X 0055BA and 20020130300007BA), Consejo Nacional de Investigación Científica y Tecnológica (CONICET PIP 0072CO and PIP 11220120100376CO), and Agencia Nacional de Promoción Científica y Tecnológica (PICT 2012‐0888) for the financial support. G.P., R.E.B., A.G.P., and L.D.J. are Research Members of CONICET (Argentina); M.R. is doctoral scholarship recipient from the same institution. The Ultraflex II (Bruker) TOF/TOF mass spectrometer was supported by a grant from ANPCYT, PME2003 No.125 and the ESI‐MS Q Exactive, Thermo Scientific, by a grant from ANPCYT, PME2011‐PPL2‐0009, CEQUIBIEM, DQB, FCEN, UBA. | ||
| 593 | |a Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Pabellón II, 3er P., Ciudad Universitaria, Buenos Aires, 1428, Argentina | ||
| 593 | |a CONICET, Universidad de Buenos Aires. Centro de Investigación en Hidratos de Carbono (CIHIDECAR), Facultad de Ciencias Exactas y Naturales, Pabellón II, 3er P. Ciudad Universitaria, Buenos Aires, 1428, Argentina | ||
| 593 | |a CONICET, Universidad de Buenos Aires. Instituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA), Facultad de Ciencias Exactas y Naturales, Pabellón II, 4to P., Ciudad Universitaria, Buenos Aires, 1428, Argentina | ||
| 593 | |a Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Pabellón II, 4to P., Ciudad Universitaria, Buenos Aires, 1428, Argentina | ||
| 690 | 1 | 0 | |a BUFADIENOLIDES |
| 690 | 1 | 0 | |a FINGERPRINT |
| 690 | 1 | 0 | |a MALDI-MS |
| 690 | 1 | 0 | |a PAROTOID SECRETION |
| 690 | 1 | 0 | |a RHINELLA ARENARUM |
| 690 | 1 | 0 | |a AMINES |
| 690 | 1 | 0 | |a DESORPTION |
| 690 | 1 | 0 | |a ELECTROSPRAY IONIZATION |
| 690 | 1 | 0 | |a ESTERS |
| 690 | 1 | 0 | |a MASS SPECTROMETRY |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a PROTEINS |
| 690 | 1 | 0 | |a BUFADIENOLIDES |
| 690 | 1 | 0 | |a FINGERPRINT |
| 690 | 1 | 0 | |a MALDI-MS |
| 690 | 1 | 0 | |a PAROTOID SECRETION |
| 690 | 1 | 0 | |a RHINELLA ARENARUM |
| 690 | 1 | 0 | |a ULTRAVIOLET LASERS |
| 690 | 1 | 0 | |a ARGININYLBUFADIENOLIDE ESTER |
| 690 | 1 | 0 | |a BUFADIENOLIDE DERIVATIVE |
| 690 | 1 | 0 | |a ESTER |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ARGININE |
| 690 | 1 | 0 | |a BUFADIENOLIDE DERIVATIVE |
| 690 | 1 | 0 | |a ESTER |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGE |
| 690 | 1 | 0 | |a ANURA |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHEMICAL COMPOSITION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DESORPTION |
| 690 | 1 | 0 | |a ELECTROSPRAY MASS SPECTROMETRY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PAROTID GLAND |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RHINELLA ARENARUM |
| 690 | 1 | 0 | |a SALIVA ANALYSIS |
| 690 | 1 | 0 | |a SALIVATION |
| 690 | 1 | 0 | |a SEASONAL VARIATION |
| 690 | 1 | 0 | |a SEX DIFFERENCE |
| 690 | 1 | 0 | |a TANDEM MASS SPECTROMETRY |
| 690 | 1 | 0 | |a ULTRAVIOLET RADIATION |
| 690 | 1 | 0 | |a ANALOGS AND DERIVATIVES |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CHORDATA |
| 690 | 1 | 0 | |a GROWTH, DEVELOPMENT AND AGING |
| 690 | 1 | 0 | |a HIGH PERFORMANCE LIQUID CHROMATOGRAPHY |
| 690 | 1 | 0 | |a MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PAROTID GLAND |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a PRINCIPAL COMPONENT ANALYSIS |
| 690 | 1 | 0 | |a PROCEDURES |
| 690 | 1 | 0 | |a SEASON |
| 690 | 1 | 0 | |a SECRETION (PROCESS) |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ARGININE |
| 690 | 1 | 0 | |a BUFANOLIDES |
| 690 | 1 | 0 | |a CHORDATA |
| 690 | 1 | 0 | |a CHROMATOGRAPHY, HIGH PRESSURE LIQUID |
| 690 | 1 | 0 | |a ESTERS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PAROTID GLAND |
| 690 | 1 | 0 | |a PRINCIPAL COMPONENT ANALYSIS |
| 690 | 1 | 0 | |a SEASONS |
| 690 | 1 | 0 | |a SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION |
| 690 | 1 | 0 | |a TANDEM MASS SPECTROMETRY |
| 653 | 0 | 0 | |a Ultraflex II TOF/TOF mass spectromete, Bruker Daltonics |
| 700 | 1 | |a Raices, M. | |
| 700 | 1 | |a Jungblut, L.D. | |
| 700 | 1 | |a Pozzi, A.G. | |
| 700 | 1 | |a Erra-Balsells, R. | |
| 773 | 0 | |d John Wiley and Sons Ltd, 2018 |g v. 53 |h pp. 465-475 |k n. 6 |p J. Mass Spectrom. |x 10765174 |t Journal of Mass Spectrometry | |
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