Oxygen-Insensitive Aggregates of Pt(II) Complexes as Phosphorescent Labels of Proteins with Luminescence Lifetime-Based Readouts
The synthesis and photophysical properties of a tailored Pt(II) complex are presented. The phosphorescence of its monomeric species in homogeneous solutions is quenched by interaction with the solvent and therefore absent even upon deoxygenation. However, aggregation-induced shielding from the envir...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
American Chemical Society
2018
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 15916caa a22013337a 4500 | ||
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| 001 | PAPER-25139 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205708.0 | ||
| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85050725112 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Delcanale, P. | |
| 245 | 1 | 0 | |a Oxygen-Insensitive Aggregates of Pt(II) Complexes as Phosphorescent Labels of Proteins with Luminescence Lifetime-Based Readouts |
| 260 | |b American Chemical Society |c 2018 | ||
| 270 | 1 | 0 | |m Viappiani, C.; Dipartimento di Scienze Matematiche, Fisiche e Informatiche, Parco Area delle Scienze 7A, Italy; email: cristiano.viappiani@unipr.it |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The synthesis and photophysical properties of a tailored Pt(II) complex are presented. The phosphorescence of its monomeric species in homogeneous solutions is quenched by interaction with the solvent and therefore absent even upon deoxygenation. However, aggregation-induced shielding from the environment and suppression of rotovibrational degrees of freedom trigger a phosphorescence turn-on that is not suppressed by molecular oxygen, despite possessing an excited-state lifetime ranging in the microsecond scale. Thus, the photoinduced production of reactive oxygen species is avoided by the suppression of diffusion-controlled Dexter-type energy transfer to triplet molecular oxygen. These aggregates emit with the characteristic green luminescence profile of monomeric complexes, indicating that Pt-Pt or excimeric interactions are negligible. Herein, we show that these aggregates can be used to label a model biomolecule (bovine serum albumin) with a microsecond-range luminescence. The protein stabilizes the aggregates, acting as a carrier in aqueous environments. Despite spectral overlaps, the green phosphorescence can be separated by time-gated detection from the dominant autofluorescence of the protein arising from a covalently bound green fluorophore that emits in the nanosecond range. Interestingly, the aggregates also acted as energy donors able to sensitize the emission of a fraction of the fluorophores bound to the protein. This resulted in a microsecond-range luminescence of the fluorescent acceptors and a shortening of the excited-state lifetime of the phosphorescent aggregates. The process that can be traced by a 1000-fold increase in the acceptor's lifetime mirrors the donor's triplet character. The implications for phosphorescence lifetime imaging are discussed. © 2018 American Chemical Society. |l eng | |
| 536 | |a Detalles de la financiación: Deutsche Forschungsgemeinschaft, Motion | ||
| 536 | |a Detalles de la financiación: Financial support from the Deutsche Forschungsgemeinschaft (DFG, EXC1003 Cells in Motion) is gratefully acknowledged. | ||
| 593 | |a Dipartimento di Scienze Matematiche, Fisiche e Informatiche, Parco Area delle Scienze 7A, Parma, 43124, Italy | ||
| 593 | |a Physikalisches Institut and Center for Nanotechnology, Westfälische Wilhelms-Universität Münster, Heisenbergstraße 11, Münster, D-48149, Germany | ||
| 593 | |a Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, Münster, D-48149, Germany | ||
| 593 | |a Departamento de Física, FCEyN, UBA, IFIBA, CONICET, Pabellón 1, Ciudad Universitaria, Buenos Aires, 1428, Argentina | ||
| 593 | |a University Hospital Münster, European Institute for Molecular Imaging, Westfälische Wilhelms-Universität Münster, Waldeyerstraße 15, Münster, D-48149, Germany | ||
| 593 | |a Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science Technology (BIST), Barcelona, Spain | ||
| 690 | 1 | 0 | |a DONOR-ACCEPTOR |
| 690 | 1 | 0 | |a ENERGY TRANSFER |
| 690 | 1 | 0 | |a LABELING |
| 690 | 1 | 0 | |a PHOTOPHYSICS |
| 690 | 1 | 0 | |a PLIM |
| 690 | 1 | 0 | |a PT(II) COMPLEX |
| 690 | 1 | 0 | |a SPECTROSCOPY |
| 690 | 1 | 0 | |a TIME-GATED SPECTROSCOPY |
| 690 | 1 | 0 | |a AGGREGATES |
| 690 | 1 | 0 | |a BINARY ALLOYS |
| 690 | 1 | 0 | |a BODY FLUIDS |
| 690 | 1 | 0 | |a DEGREES OF FREEDOM (MECHANICS) |
| 690 | 1 | 0 | |a ENERGY TRANSFER |
| 690 | 1 | 0 | |a EXCITED STATES |
| 690 | 1 | 0 | |a FLUOROPHORES |
| 690 | 1 | 0 | |a LABELING |
| 690 | 1 | 0 | |a MOLECULAR OXYGEN |
| 690 | 1 | 0 | |a PHOSPHORESCENCE |
| 690 | 1 | 0 | |a PROTEINS |
| 690 | 1 | 0 | |a SPECTROSCOPY |
| 690 | 1 | 0 | |a DONOR ACCEPTORS |
| 690 | 1 | 0 | |a EXCITED STATE LIFETIMES |
| 690 | 1 | 0 | |a PHOSPHORESCENCE LIFETIME |
| 690 | 1 | 0 | |a PHOTOPHYSICAL PROPERTIES |
| 690 | 1 | 0 | |a PHOTOPHYSICS |
| 690 | 1 | 0 | |a PLIM |
| 690 | 1 | 0 | |a PT COMPLEXES |
| 690 | 1 | 0 | |a REACTIVE OXYGEN SPECIES |
| 690 | 1 | 0 | |a PLATINUM COMPOUNDS |
| 700 | 1 | |a Galstyan, A. | |
| 700 | 1 | |a Daniliuc, C.G. | |
| 700 | 1 | |a Grecco, H.E. | |
| 700 | 1 | |a Abbruzzetti, S. | |
| 700 | 1 | |a Faust, A. | |
| 700 | 1 | |a Viappiani, C. | |
| 700 | 1 | |a Strassert, C.A. | |
| 773 | 0 | |d American Chemical Society, 2018 |g v. 10 |h pp. 24361-24369 |k n. 29 |p ACS Appl. Mater. Interfaces |x 19448244 |t ACS Applied Materials and Interfaces | |
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