Effects of waterborne exposure to the antidepressant fluoxetine on swimming, shoaling and anxiety behaviours of the mosquitofish Gambusia holbrooki

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Chemical pollution from pharmaceuticals is increasingly recognized as a major hazard to the aquatic biota. Among the wide variety of pharmaceuticals, fluoxetine (FLX) is one of the most widely prescribed antidepressants, and therefore, it is frequently identified in the aquatic environment. As FLX i...

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Autor principal: Meijide, F.J
Otros Autores: Da Cuña, R.H, Prieto, J.P, Dorelle, L.S, Babay, P.A, Lo Nostro, F.L
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Academic Press 2018
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 cas  |a fluoxetine, 54910-89-3, 56296-78-7, 59333-67-4; Antidepressive Agents; Fluoxetine; Water Pollutants, Chemical 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a EESAD 
100 1 |a Meijide, F.J. 
245 1 0 |a Effects of waterborne exposure to the antidepressant fluoxetine on swimming, shoaling and anxiety behaviours of the mosquitofish Gambusia holbrooki 
260 |b Academic Press  |c 2018 
270 1 0 |m Meijide, F.J.; Lab. Ecotoxicología Acuática, DBBE, FCEN, Universidad de Buenos Aires, Int. Güiraldes 2160, Ciudad UniversitariaArgentina; email: fmeiji@bg.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Chemical pollution from pharmaceuticals is increasingly recognized as a major hazard to the aquatic biota. Among the wide variety of pharmaceuticals, fluoxetine (FLX) is one of the most widely prescribed antidepressants, and therefore, it is frequently identified in the aquatic environment. As FLX is designed to alter human behaviour and many physiological pathways are conserved across vertebrates, this drug may affect the behaviour of fish living in FLX-polluted environments. Here, we exposed groups of female mosquitofish Gambusia holbrooki to waterborne FLX for 14 days, under semi-static conditions with daily renewal of test solutions. Following exposure, we conducted a set of behavioural assays in individual fish, aimed at assessing the effects of FLX on their locomotor activity and behavioural responses. We found that FLX impaired swimming behaviour at high concentrations (25 μg/L and 50 μg/L) but not at low concentrations close to environmental levels (1 μg/L and 5 μg/L). When swimming activity was assessed 5 min after transfer of the focal fish to the testing tank, 50 μg/L FLX was the only concentration showing significant effects. However, when the same trials were performed 24 h later, 25 μg/L FLX turned out to be an effect concentration in addition to 50 μg/L. Interestingly, these concentrations would elicit fish plasma concentrations comprised within the range of human therapeutic doses. When subjected to a light/dark preference test, fish showed tendency to remain less time in the dark area at high FLX concentrations, thus suggesting an anti-anxiety response. Shoaling behaviour was not affected by FLX exposure. Our study contributes to the growing body of literature evaluating the effects of FLX on animal behaviour. Regarding the experimental design used in behavioural testing, our findings suggest that focal fish should be subjected to long habituation periods, namely of at least a few hours, in order to better assess the effects of drug exposure. © 2018 Elsevier Inc.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires 
536 |a Detalles de la financiación: Secretaría de Ciencia y Técnica, Universidad de Buenos Aires, x056BA 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 1021 
536 |a Detalles de la financiación: The financial support for this work was provided by grants from Universidad de Buenos Aires ( UBACyT x056BA ; Lo Nostro) and CONICET ( PIP 1021 ; Lo Nostro). 
593 |a Laboratorio de Ecotoxicología Acuática, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, C1428EGA, Argentina 
593 |a Instituto de Biodiversidad y Biología Experimental y Aplicada, CONICET-UBA, Ciudad Autónoma de Buenos Aires, Argentina 
593 |a Departamento de Neurofarmacología Experimental, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay 
593 |a Gerencia Química, Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica, Buenos Aires, 1650, Argentina 
690 1 0 |a BEHAVIOURAL TESTS 
690 1 0 |a FLUOXETINE 
690 1 0 |a GAMBUSIA HOLBROOKI 
690 1 0 |a PHARMACEUTICAL POLLUTION 
690 1 0 |a POECILIIDAE 
690 1 0 |a SWIMMING ACTIVITY 
690 1 0 |a FLUOXETINE 
690 1 0 |a ANTIDEPRESSANT AGENT 
690 1 0 |a FLUOXETINE 
690 1 0 |a AQUATIC ENVIRONMENT 
690 1 0 |a BEHAVIORAL RESPONSE 
690 1 0 |a CYPRINID 
690 1 0 |a DRUG 
690 1 0 |a POLLUTION EFFECT 
690 1 0 |a POLLUTION EXPOSURE 
690 1 0 |a SWIMMING 
690 1 0 |a TESTING METHOD 
690 1 0 |a ADULT 
690 1 0 |a ANIMAL BEHAVIOR 
690 1 0 |a ANXIETY 
690 1 0 |a ARTICLE 
690 1 0 |a BEHAVIOR CHANGE 
690 1 0 |a CONCENTRATION (PARAMETERS) 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a ECOTOXICOLOGY 
690 1 0 |a ENVIRONMENTAL EXPOSURE 
690 1 0 |a FEMALE 
690 1 0 |a GAMBUSIA HOLBROOKI 
690 1 0 |a LIGHT DARK CYCLE 
690 1 0 |a LOCOMOTION 
690 1 0 |a NONHUMAN 
690 1 0 |a SWIMMING 
690 1 0 |a WATER ANALYSIS 
690 1 0 |a ANIMAL 
690 1 0 |a ANIMAL BEHAVIOR 
690 1 0 |a CYPRINODONTIFORMES 
690 1 0 |a DRUG EFFECT 
690 1 0 |a PHYSIOLOGY 
690 1 0 |a SWIMMING 
690 1 0 |a TOXICITY 
690 1 0 |a TOXICITY TESTING 
690 1 0 |a WATER POLLUTANT 
690 1 0 |a ANIMALIA 
690 1 0 |a GAMBUSIA AFFINIS 
690 1 0 |a GAMBUSIA HOLBROOKI 
690 1 0 |a POECILIIDAE 
690 1 0 |a VERTEBRATA 
690 1 0 |a ANIMALS 
690 1 0 |a ANTIDEPRESSIVE AGENTS 
690 1 0 |a BEHAVIOR, ANIMAL 
690 1 0 |a CYPRINODONTIFORMES 
690 1 0 |a FEMALE 
690 1 0 |a FLUOXETINE 
690 1 0 |a SWIMMING 
690 1 0 |a TOXICITY TESTS 
690 1 0 |a WATER POLLUTANTS, CHEMICAL 
700 1 |a Da Cuña, R.H. 
700 1 |a Prieto, J.P. 
700 1 |a Dorelle, L.S. 
700 1 |a Babay, P.A. 
700 1 |a Lo Nostro, F.L. 
773 0 |d Academic Press, 2018  |g v. 163  |h pp. 646-655  |p Ecotoxicol. Environ. Saf.  |x 01476513  |w (AR-BaUEN)CENRE-4483  |t Ecotoxicology and Environmental Safety 
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856 4 0 |u https://doi.org/10.1016/j.ecoenv.2018.07.085  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_01476513_v163_n_p646_Meijide  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v163_n_p646_Meijide  |y Registro en la Biblioteca Digital 
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