Obesity alters the uterine environment before pregnancy
Obesity is a metabolic disorder that predisposes to numerous diseases and has become a major global public health concern. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects Western diet habits. Previously, we described that CAF administration for 60 da...
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Elsevier Inc.
2018
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| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
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| 024 | 7 | |2 cas |a salbutamol, 18559-94-9, 35763-26-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JNBIE | ||
| 100 | 1 | |a Bazzano, M.V. | |
| 245 | 1 | 0 | |a Obesity alters the uterine environment before pregnancy |
| 260 | |b Elsevier Inc. |c 2018 | ||
| 270 | 1 | 0 | |m Elia, E.M.; Laboratorio de Biología del Desarrollo, IFIBYNE-CONICET-UBA, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II, 4, Argentina; email: evelinmariel@gmail.com.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Obesity is a metabolic disorder that predisposes to numerous diseases and has become a major global public health concern. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects Western diet habits. Previously, we described that CAF administration for 60 days induces obesity in female rats and their fetuses develop macrosomia. Given that, in our model, rats are not genetically modified and that obese mothers were fed standard chow during pregnancy, the aim of the current study was to test the hypothesis that obesity alters the intrauterine environment prior to pregnancy, and this may explain the exacerbated fetal weight gain. We found that uteri from obese rats during the estrous phase developed insulin resistance through mechanisms that involve the induction of uterine hypoxia and the down-regulation of the insulin receptor gene. Moreover, uterine cell proliferation was induced by obesity concomitantly with the reduction in the uterine contractile response to a β2 AR agonist, salbutamol, and this may be consequence of the down-regulation in the uterine β2 AR expression. We conclude that CAF-induced obesity alters the uterine environment in rats during the estrous phase and may cause the fetal macrosomia previously described by us in obese animals. The lower sensitivity of the uterus to a relaxation stimulus (salbutamol) is not a minor fact given that for implantation to occur the uterus must be relaxed for embryo nidation. Thus, the alteration in the uterine quiescence may impair implantation and, consequently, the foregoing pregnancy. © 2018 Elsevier Inc. |l eng | |
| 593 | |a Universidad de Buenos Aires (UBA), Facultad de Ciencias Exactas y Naturales (FCEN), Buenos Aires, Argentina | ||
| 593 | |a Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA-Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina | ||
| 593 | |a UBA, FCEN, Departamento de Fisiología, Biología Molecular y Celular, Buenos Aires, Argentina | ||
| 593 | |a UBA, FCEN, Departamento de Biodiversidad y Bilogía Experimental, Buenos Aires, Argentina | ||
| 593 | |a UBA, Facultad de Medicina, Buenos Aires, Argentina | ||
| 593 | |a CONICET-UBA- Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ADRENERGIC RECEPTOR |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a OBESITY |
| 690 | 1 | 0 | |a UTERINE CONTRACTILE ACTIVITY |
| 690 | 1 | 0 | |a UTERUS |
| 690 | 1 | 0 | |a BETA 2 ADRENERGIC RECEPTOR |
| 690 | 1 | 0 | |a INSULIN RECEPTOR |
| 690 | 1 | 0 | |a SALBUTAMOL |
| 690 | 1 | 0 | |a ABDOMINAL CIRCUMFERENCE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BODY WEIGHT GAIN |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DOWN REGULATION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FETUS WEIGHT |
| 690 | 1 | 0 | |a GLUCOSE TRANSPORT |
| 690 | 1 | 0 | |a IMMUNOFLUORESCENCE |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a INSULIN RESISTANCE |
| 690 | 1 | 0 | |a MACROSOMIA |
| 690 | 1 | 0 | |a MYOMETRIUM |
| 690 | 1 | 0 | |a NIDATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OBESITY |
| 690 | 1 | 0 | |a POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PREGNANCY RATE |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a REAL TIME POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a RNA EXTRACTION |
| 690 | 1 | 0 | |a UTERUS |
| 690 | 1 | 0 | |a UTERUS CONTRACTION |
| 690 | 1 | 0 | |a WESTERN BLOTTING |
| 700 | 1 | |a Sarrible, G.B. | |
| 700 | 1 | |a Martinez, N. | |
| 700 | 1 | |a Berón de Astrada, M. | |
| 700 | 1 | |a Elia, E.M. | |
| 773 | 0 | |d Elsevier Inc., 2018 |g v. 62 |h pp. 181-191 |p J. Nutr. Biochem. |x 09552863 |w (AR-BaUEN)CENRE-5723 |t Journal of Nutritional Biochemistry | |
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