Drug Abuse and the RAS

Interactions between the pedunculopontine (PPN) and ventral tegmental area (VTA) have been described as key brain circuitry that mediates psychostimulant-mediated reward. Intranuclear PPN/laterodorsal tegmental injections of cholinergic receptor agonists or antagonists have helped clarify the role o...

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Autor principal: Urbano, F.J
Otros Autores: Bisagno, V., Garcia-Rill, E.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Elsevier Inc. 2015
Acceso en línea:Registro en Scopus
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100 1 |a Urbano, F.J. 
245 1 0 |a Drug Abuse and the RAS 
260 |b Elsevier Inc.  |c 2015 
270 1 0 |m Urbano, F.J.; Laboratorio Fisiologia y Biologia Molecular, Facultad Ciencias Exactas, Ciudad Universitaria, Argentina 
506 |2 openaire  |e Política editorial 
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520 3 |a Interactions between the pedunculopontine (PPN) and ventral tegmental area (VTA) have been described as key brain circuitry that mediates psychostimulant-mediated reward. Intranuclear PPN/laterodorsal tegmental injections of cholinergic receptor agonists or antagonists have helped clarify the role of these nuclei on psychostimulant-induced locomotion. Also, nicotine has been shown to have an inhibitory effect on the PPN, at least initially reducing arousal. PPN activation has been involved in the animal's voluntary search for psychostimulants. On the other hand, CNS depressants like ethanol might reduce arousal by a mechanism involving the direct inhibition of the PPN. In conclusion, neural activity in the PPN is key not only to maintaining arousal but also to affecting the level of psychostimulant and depressant administration. © 2015 Elsevier Inc. All rights reserved.  |l eng 
593 |a Laboratorio Fisiologia y Biologia Molecular, Facultad Ciencias Exactas, Ciudad Universitaria, Buenos Aires, Argentina 
593 |a Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States 
690 1 0 |a AMPHETAMINE 
690 1 0 |a BENZODIAZEPINES 
690 1 0 |a COCAINE 
690 1 0 |a DOPAMINE 
690 1 0 |a NICOTINE 
690 1 0 |a PSYCHOSTIMULANT 
690 1 0 |a TOBACCO 
700 1 |a Bisagno, V. 
700 1 |a Garcia-Rill, E. 
773 0 |d Elsevier Inc., 2015  |h pp. 277-289  |p Waking and the Reticular Act. Syst. in Health and Dis.  |z 9780128013854  |z 9780128016329  |t Waking and the Reticular Activating System in Health and Disease 
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