Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism?

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Interactions among different species of parasites co-infecting the same host could be synergistic or antagonistic. These interactions may modify both the frequency of infected hosts and their infectiousness, and therefore impact on transmission dynamics. This study determined the infectiousness of T...

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Autor principal: Enriquez, G.F
Otros Autores: Garbossa, G., Macchiaverna, N.P, Argibay, H.D, Bua, J., Gürtler, Ricardo Esteban, Cardinal, M.V
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Publicado: Elsevier B.V. 2016
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100 1 |a Enriquez, G.F. 
245 1 3 |a Is the infectiousness of dogs naturally infected with Trypanosoma cruzi associated with poly-parasitism? 
260 |b Elsevier B.V.  |c 2016 
270 1 0 |m Cardinal, M.V.; Laboratory of Eco-Epidemiology, Faculty of Exact and Natural Sciences, University of Buenos Aires, Ciudad UniversitariaArgentina; email: mvcardinal@ege.fcen.uba.ar 
504 |a Álvarez, M.G., Hernández, Y., Bertocchi, G., Fernández, M., Lococo, B., Ramírez, J.C., Cura, C., Viotti, R., New scheme of intermittent benznidazole administration in patients chronically infected with Trypanosoma cruzi. A pilot short-term follow-up study in adult patients (2015) Antimicrob. Agents Chemother., 60, pp. 833-837 
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506 |2 openaire  |e Política editorial 
520 3 |a Interactions among different species of parasites co-infecting the same host could be synergistic or antagonistic. These interactions may modify both the frequency of infected hosts and their infectiousness, and therefore impact on transmission dynamics. This study determined the infectiousness of Trypanosoma cruzi-seropositive dogs (using xenodiagnosis) and their parasite load (quantified by qPCR), and tested the association between both variables and the presence of concomitant endoparasites. A cross-sectional serosurvey conducted in eight rural villages from Pampa del Indio and neighboring municipalities (northeastern Argentina) detected 32 T. cruzi-seropositive dogs out of 217 individuals examined for infection. Both the infectiousness to the vector Triatoma infestans and parasite load of T. cruzi-seropositive dogs examined were heterogeneous. A statistically significant, nine-fold higher mean infectiousness was registered in T. cruzi-seropositive dogs co-infected with Ancylostoma caninum and a trematode than in T. cruzi-seropositive dogs without these infections. The median parasite load of T. cruzi was also significantly higher in dogs co-infected with these helminths. An opposite trend was observed in T. cruzi-seropositive dogs that were serologically positive to Toxoplasma gondii or Neospora caninum relative to dogs seronegative for these parasites. Using multiple logistic regression analysis with random effects, we found a positive and significant association between the infectiousness of T. cruzi-seropositive dogs and co-infections with A. caninum and a trematode. Our results suggest that co-infections may be a modifier of host infectiousness in dogs naturally infected with T. cruzi. © 2016 Elsevier B.V.  |l eng 
536 |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica 
536 |a Detalles de la financiación: Universidad de Buenos Aires 
536 |a Detalles de la financiación: This study received financial support from Agencia Nacional de Promoción Científica y Tecnológica ; Agencia Nacional de Promoción Científica y Tecnológica and GlaxoSmithKline , and University of Buenos Aires . J.B, R.E.G. and M.V.C. are members of CONICET Researcher’s Career. 
536 |a Detalles de la financiación: We are grateful to Dra. Paula Sartor (Dante Tardelli Hospital, Pampa del Indio, Chaco Province, Argentina), Ludmila López Arias, Elisa Helman and Andrea Servián (Laboratory of Clinical and Environmental Parasitology, Faculty of Exact and Natural Sciences, University of Buenos Aires, Argentina) for laboratory and field work assistance. Romina Piccinali, Sol Gaspe, Pilar Fernández, Yael Provecho, Carla Cecere, Lucía Rodríguez Planes, Marcela Orozco for valuable comments and Dr. Rodrigo E.F. Sanabria (Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús, Buenos Aires Province) for kindly providing Fasciola hepatica eggs and adult worms. Special thanks to the villagers of Pampa del Indio for kindly welcoming us into their homes and cooperating with the investigation. Appendix A 
593 |a Laboratory of Eco-Epidemiology, Faculty of Exact and Natural Sciences, University of Buenos Aires, Argentina 
593 |a Institute of Ecology, Genetics and Evolution of Buenos Aires (UBA-CONICET), Argentina 
593 |a Laboratory of Clinical and Environmental Parasitology, Faculty of Exact and Natural Sciences, University of Buenos Aires, (IQUIBICEN-CONICET-UBA), Public Health Research Institute, Argentina 
593 |a National Institute of Parasitology Dr. M. Fatala Chaben, National Administration of Laboratories and Inst.s of Health Dr. C.G. Malbrán, Buenos Aires, Argentina 
651 4 |a ARGENTINA 
690 1 0 |a DOGS 
690 1 0 |a INFECTIOUSNESS 
690 1 0 |a INTERSPECIES INTERACTIONS 
690 1 0 |a POLY-PARASITISM 
690 1 0 |a TRYPANOSOMA CRUZI 
690 1 0 |a ADULT 
690 1 0 |a ANCYLOSTOMA CANINUM 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ARTICLE 
690 1 0 |a CHAGAS DISEASE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a CROSS-SECTIONAL STUDY 
690 1 0 |a DISEASE TRANSMISSION 
690 1 0 |a HOST PARASITE INTERACTION 
690 1 0 |a NEOSPORA CANINUM 
690 1 0 |a NONHUMAN 
690 1 0 |a PARASITE LOAD 
690 1 0 |a PARASITISM 
690 1 0 |a POLYMERASE CHAIN REACTION 
690 1 0 |a POLYPARASITISM 
690 1 0 |a RURAL AREA 
690 1 0 |a TOXOPLASMA GONDII 
690 1 0 |a TRIATOMA INFESTANS 
690 1 0 |a TRYPANOSOMA CRUZI 
690 1 0 |a XENODIAGNOSIS 
690 1 0 |a ANIMAL 
690 1 0 |a ANIMAL PARASITOSIS 
690 1 0 |a CHAGAS DISEASE 
690 1 0 |a COMPLICATION 
690 1 0 |a DOG 
690 1 0 |a DOG DISEASE 
690 1 0 |a ISOLATION AND PURIFICATION 
690 1 0 |a MIXED INFECTION 
690 1 0 |a PARASITOLOGY 
690 1 0 |a PATHOLOGY 
690 1 0 |a VETERINARY 
690 1 0 |a ANIMALS 
690 1 0 |a CHAGAS DISEASE 
690 1 0 |a COINFECTION 
690 1 0 |a DOG DISEASES 
690 1 0 |a DOGS 
690 1 0 |a HELMINTHIASIS, ANIMAL 
690 1 0 |a TRYPANOSOMA CRUZI 
700 1 |a Garbossa, G. 
700 1 |a Macchiaverna, N.P. 
700 1 |a Argibay, H.D. 
700 1 |a Bua, J. 
700 1 |a Gürtler, Ricardo Esteban 
700 1 |a Cardinal, M.V. 
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