Heterogeneous distribution of histone methylation in mature human sperm
Purpose: To analyze the presence of various histone modifications in ejaculated human spermatozoa. Methods: In this prospective study, seminal ejaculates from 39 normozoospermic individuals were evaluated for semen analysis and the presence of histone modifications in isolated nuclei. Results: We ob...
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| Otros Autores: | , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Springer New York LLC
2014
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08129caa a22010697a 4500 | ||
|---|---|---|---|
| 001 | PAPER-24040 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205549.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84895885278 | |
| 024 | 7 | |2 cas |a histone, 9062-68-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JARGE | ||
| 100 | 1 | |a La Spina, F.A. | |
| 245 | 1 | 0 | |a Heterogeneous distribution of histone methylation in mature human sperm |
| 260 | |b Springer New York LLC |c 2014 | ||
| 270 | 1 | 0 | |m Buffone, M.G.; Instituto de Biología y Medicina Experimental, CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina; email: mgbuffone@gmail.com |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Sasaki, H., Matsui, Y., Epigenetic events in mammalian germ-cell development: Reprogramming and beyond (2008) Nat Rev Genet, 9 (2), pp. 129-140 | ||
| 504 | |a Oliva, R., Dixon, G.H., Vertebrate protamine gene evolution I. Sequence alignments and gene structure (1990) Journal of Molecular Evolution, 30 (4), pp. 333-346 | ||
| 504 | |a Kasinsky, H.E., Eirín-López, J.M., Ausió, J., Protamines: Structural complexity, evolution and chromatin patterning (2011) Protein Pept Lett, 18 (8), pp. 755-771 | ||
| 504 | |a Hammoud, S.S., Nix, D.A., Zhang, H., Purwar, J., Carrell, D.T., Cairns, B.R., Distinctive chromatin in human sperm packages genes for embryo development (2009) Nature, 460 (7254), pp. 473-478 | ||
| 504 | |a Hammoud, S.S., Nix, D.A., Hammoud, A.O., Gibson, M., Cairns, B.R., Carrell, D.T., Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men (2011) Hum Reprod, 26 (9), pp. 2558-2569 | ||
| 504 | |a Barratt, C., Aitken, R.J., Bjorndahl, L., Carrell, D.T., De Boer, P., Kvist, U., Sperm DNA: Organization, protection and vulnerability: From basic science to clinical applications, a position report (2010) Hum Reprod, 25 (4), pp. 824-838 | ||
| 504 | |a Buffone, M.G., Doncel, G.F., Calamera, J.C., Verstraeten, S.V., Capacitation-associated changes in membrane fluidity in asthenozoospermic human spermatozoa (2009) Int J Androl, 32 (4), pp. 360-375 | ||
| 504 | |a De Yebra, L., Oliva, R., Rapid anlaysis of mammalian sperm nuclear proteins (1993) Analytical Biochemistry, 209 (1), pp. 201-203. , DOI 10.1006/abio.1993.1104 | ||
| 504 | |a Bedford-Guaus, S.J., McPartlin, L.A., Xie, J., Westmiller, S.L., Buffone, M.G., Roberson, M.S., Molecular cloning and characterization of phospholipase C zeta in equine sperm and testis reveals species-specific differences in expression of catalytically active protein (2011) Biol Reprod, 85 (1), pp. 78-88. , Jul | ||
| 504 | |a Zahn, A., Furlong, L.I., Biancotti, J.C., Ghiringhelli, P.D., Marin-Briggiler, C.I., Vazquez-Levin, M.H., Evaluation of the proacrosin/acrosin system and its mechanism of activation in human sperm extracts (2002) Journal of Reproductive Immunology, 54 (1-2), pp. 43-63. , DOI 10.1016/S0165-0378(01)00080-8, PII S0165037801000808 | ||
| 504 | |a Oliva, R., Bazett-Jones, D.P., Locklear, L., Dixon, G.H., Histone hyperacetylation can induce unfolding of the nucleosome core particle (1990) Nucleic Acids Res, 18 (9), pp. 2739-2747 | ||
| 504 | |a Buffone, M.G., Doncel, G.F., Briggiler, C.I.M., Vazquez-Levin, M.H., Calamera, J.C., Human sperm subpopulations: Relationship between functional quality and protein tyrosine phosphorylation (2004) Human Reproduction, 19 (1), pp. 139-146. , DOI 10.1093/humrep/deh040 | ||
| 504 | |a Glaser, S., Lubitz, S., The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis (2009) Epigenetics Chromatin, 2 (1), p. 5 | ||
| 504 | |a Turner, J.M.A., Mahadevaiah, S.K., Fernandez-Capetillo, O., Nussenzweig, A., Xu, X., Deng, C.-X., Burgoyne, P.S., Silencing of unsynapsed meiotic chromosomes in the mouse (2005) Nature Genetics, 37 (1), pp. 41-47. , DOI 10.1038/ng1484 | ||
| 504 | |a (1999) WHO Laboratory Manual for the Examination and Processing of Human Semen, , Cambridge University Press | ||
| 520 | 3 | |a Purpose: To analyze the presence of various histone modifications in ejaculated human spermatozoa. Methods: In this prospective study, seminal ejaculates from 39 normozoospermic individuals were evaluated for semen analysis and the presence of histone modifications in isolated nuclei. Results: We observed heterogeneous presence of histone methylation in normal mature human sperm. We observed that 12 to 30 % of the nuclei of normal sperm contain a heterogeneous distribution of the marks H3K4Me1, H3K9Me2, H3K4Me3, H3K79Me2, and H3K36Me3. Moreover, the presence of these marks is higher in the poor motile fraction of the ejaculate, which is associated with poor morphology and functional quality. In contrast, we did not observe histone acetylation (H3K4Ac and H4K5Ac) in normal or abnormal mature human sperm. Conclusions: Defects in the process of spermatogenesis may alter the correct epigenetic programing in mature sperm. Further studies are required to evaluate the impact of these findings in human infertility. © 2013 Springer Science+Business Media. |l eng | |
| 536 | |a Detalles de la financiación: University of Missouri | ||
| 536 | |a Detalles de la financiación: Acknowledgments We would like to thank Drs. Paula Stein, Juan G. Alvarez, Juan C. Calvo and Lucrecia Calvo and Alejandra Vitale for their comments and technical assistance. RMR is supported by F21C Reproductive Biology Group, University of Missouri. MGB, VJ, MR are supported by CONICET, Argentina. | ||
| 593 | |a Instituto de Biología y Medicina Experimental, CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 593 | |a Centro Médico Seremas, Buenos Aires, Argentina | ||
| 593 | |a Animal Science Research Center, Division of Animal Sciences, University of Missouri, Columbia, MO, United States | ||
| 690 | 1 | 0 | |a EPIGENETIC |
| 690 | 1 | 0 | |a HISTONE MODIFICATIONS |
| 690 | 1 | 0 | |a HUMAN SPERM |
| 690 | 1 | 0 | |a SPERM SUBPOPULATIONS |
| 690 | 1 | 0 | |a HISTONE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL STRUCTURE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EJACULATION |
| 690 | 1 | 0 | |a HELA CELL |
| 690 | 1 | 0 | |a HISTONE ACETYLATION |
| 690 | 1 | 0 | |a HISTONE METHYLATION |
| 690 | 1 | 0 | |a HISTONE MODIFICATION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a IMMUNOCYTOCHEMISTRY |
| 690 | 1 | 0 | |a IMMUNOFLUORESCENCE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NORMAL HUMAN |
| 690 | 1 | 0 | |a NUCLEOSOME |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROSPECTIVE STUDY |
| 690 | 1 | 0 | |a PROTEIN PROCESSING |
| 690 | 1 | 0 | |a SEMEN ANALYSIS |
| 690 | 1 | 0 | |a SPERMATID |
| 690 | 1 | 0 | |a SPERMATOZOON |
| 690 | 1 | 0 | |a SPERMATOZOON MATURATION |
| 690 | 1 | 0 | |a CELL NUCLEUS |
| 690 | 1 | 0 | |a EPIGENESIS, GENETIC |
| 690 | 1 | 0 | |a HELA CELLS |
| 690 | 1 | 0 | |a HISTONE-LYSINE N-METHYLTRANSFERASE |
| 690 | 1 | 0 | |a HISTONES |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METHYLATION |
| 690 | 1 | 0 | |a SEMEN ANALYSIS |
| 690 | 1 | 0 | |a SPERMATOGENESIS |
| 690 | 1 | 0 | |a SPERMATOZOA |
| 700 | 1 | |a Romanato, M. | |
| 700 | 1 | |a Brugo-Olmedo, S. | |
| 700 | 1 | |a De Vincentiis, S. | |
| 700 | 1 | |a Julianelli, V. | |
| 700 | 1 | |a Rivera, R.M. | |
| 700 | 1 | |a Buffone, M.G. | |
| 773 | 0 | |d Springer New York LLC, 2014 |g v. 31 |h pp. 45-49 |k n. 1 |p J. Assisted Reprod. Genet. |x 10580468 |t Journal of Assisted Reproduction and Genetics | |
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