Expression and methylation status of female-predominant GH-dependent liver genes are modified by neonatal androgenization in female mice
Neonatal androgenization masculinizes the GH axis and thus may impact on liver gene regulation. Neonatal testosterone administration to female mice decreased (defeminized) female predominant GH-dependent liver gene expression (Hnf6, Adh1, Prlr, Cyp3a41) and did not modify male predominant genes (Cyp...
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2014
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| LEADER | 17484caa a22017057a 4500 | ||
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| 003 | AR-BaUEN | ||
| 005 | 20230518205538.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84888416545 | |
| 024 | 7 | |2 Molecular Sequence Numbers |a GENBANK: NM_007825, NM_008262; | |
| 024 | 7 | |2 cas |a DNA, 9007-49-2; growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; testosterone, 58-22-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MCEND | ||
| 100 | 1 | |a Ramirez, M.C. | |
| 245 | 1 | 0 | |a Expression and methylation status of female-predominant GH-dependent liver genes are modified by neonatal androgenization in female mice |
| 260 | |c 2014 | ||
| 270 | 1 | 0 | |m Becu-Villalobos, D.; Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, V. Obligado 2490, 1428 Buenos Aires, Argentina; email: dbecu@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Neonatal androgenization masculinizes the GH axis and thus may impact on liver gene regulation. Neonatal testosterone administration to female mice decreased (defeminized) female predominant GH-dependent liver gene expression (Hnf6, Adh1, Prlr, Cyp3a41) and did not modify male predominant genes (Cyp7b1, Cyp4a12, Slp). Female predominance of Cis mRNA, an inhibitor of episodic GH signaling pathway, was unaltered. At birth, Cyp7b1 promoter exhibited a higher methylation status in female livers, while the Hnf6 promoter was equally methylated in both sexes; no differences in gene expression were detected at this age. In adulthood, consistent with sex specific predominance, lower methylation status was determined for the Cyp7b1 promoter in males, and for the Hnf6 promoter in females, and this last difference was prevented by neonatal androgenization. Therefore, early steroid treatment or eventually endocrine disruptor exposure may alter methylation status and sexual dimorphic expression of liver genes, and consequently modify liver physiology in females. © 2013 Elsevier Ireland Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT N459 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 640 | ||
| 536 | |a Detalles de la financiación: Authorship contribution: Participated in research design: Becu-Villalobos, Ramirez. Conducted experiments: Ramirez, Ornstein. Zubeldía-Brenner, Wargon. Performed data analysis: Ramirez, Becu-Villalobos. Wrote or contributed to the writing of the manuscript: Becu-Villalobos, Ramirez. Funding sources: This work was supported by the Consejo de Investigaciones Cientificas y Tecnicas (CONICET, Grant PIP 640, 2009, to DBV), and Agencia Nacional de Promoción Científica y Técnica, Buenos Aires, Argentina (Grant PICT N459, 2010, to DBV). Funding sources had no involvement in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. | ||
| 593 | |a Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, V. Obligado 2490, 1428 Buenos Aires, Argentina | ||
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| 700 | 1 | |a Zubeldía-Brenner, L. | |
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| 700 | 1 | |a Ornstein, A.M. | |
| 700 | 1 | |a Becu-Villalobos, D. | |
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