Experimental in vitro infection of rat osteoblasts with measles virus stimulates osteogenic differentiation
In this work we characterized the infection of a primary culture of rat osteoblastic lineage cells (OBCs) with measles virus (MeV) and the effect of infection on cell differentiation and maturation. Infection of OBCs with MeV led to high titers of infectivity released early after infection. Also, an...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Academic Press Inc.
2014
|
| Materias: | |
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 13599caa a22017177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-23813 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205533.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84908390115 | |
| 024 | 7 | |2 cas |a 2 morpholino 8 phenylchromone, 154447-36-6; adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5; alkaline phosphatase, 9001-78-9; phosphatidylinositol 3 kinase, 115926-52-8; procollagen C proteinase, 68651-95-6; protein, 67254-75-5; protein kinase B, 148640-14-6; adenosine 5' o (3 thiotriphosphate), 35094-46-3 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBRCA | ||
| 100 | 1 | |a Ayala-Peña, V. | |
| 245 | 1 | 0 | |a Experimental in vitro infection of rat osteoblasts with measles virus stimulates osteogenic differentiation |
| 260 | |b Academic Press Inc. |c 2014 | ||
| 270 | 1 | 0 | |m Scolaro, L.; Laboratorio de Virología, Departamento de Química Biológica, Universidad de Buenos Aires, Pabellón 2, Piso 4, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Ikegame, M., Ishibashi, O., Yoshizawa, T., Shimomura, J., Komori, T., Ozawa, H., Kawashima, H., Tensile stress induces bone morphogenetic protein 4 in preosteoblastic and fibroblastic cells, which later differentiate into osteoblasts leading to osteogenesis in the mouse calvariae in organ culture (2001) J. Bone Miner. Res., 16, pp. 24-32 | ||
| 504 | |a Tanno, M., Furukawa, K.I., Ueyama, K., Harata, S., Motomura, S., Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments (2003) Bone, 33, pp. 475-484 | ||
| 504 | |a Rath, B., Nam, J., Knobloch, T.J., Lannutti, J.J., Agarwal, S., Compressive forces induce osteogenic gene expression in calvarial osteoblasts (2008) J. Biomech., 41, pp. 1095-1103 | ||
| 504 | |a Tseng, W.P., Yang, S.N., Lai, C.H., Tang, C.H., Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts (2010) J. Cell. Physiol., 223, pp. 810-818 | ||
| 504 | |a Becker, J., Schuppan, D., Benzian, H., Bals, T., Hahn, E.G., Cantaluppi, C., Reichart, P., Immunohistochemical distribution of collagens types IV, V, and VI and of pro-collagens types i and III in human alveolar bone and dentine (1986) J. Histochem. Cytochem., 34, pp. 1417-1429 | ||
| 504 | |a Mikuni-Takagaki, Y., Kakai, Y., Satoyoshi, M., Kawano, E., Suzuki, Y., Kawase, T., Saito, S., Matrix mineralization and the differentiation of osteocyte-like cells in culture (1995) J. Bone Miner. Res., 10, pp. 231-242 | ||
| 504 | |a Sandberg, M., Autio-Harmainen, H., Vuorio, E., Localization of the expression of types I, III, and IV collagen, TGF-beta 1 and c-fos genes in developing human calvarial bones (1988) Dev. Biol., 130, pp. 324-334 | ||
| 504 | |a Urist, M.R., Bone: Formation by autoinduction (1965) Science, 150, pp. 893-899 | ||
| 504 | |a Ayala-Peña, V.B., Scolaro, L.A., Santillán, G.E., ATP and UTP stimulate bone morphogenetic protein-2, -4 and -5 gene expression and mineralization by rat primary osteoblasts involving PI3K/AKTpathway (2013) Exp. Cell Res., 1, pp. 2028-2036 | ||
| 504 | |a Csomor, P., Liktor, B., Liktor, B., Szekanecz, Z., Sziklai, I., Karosi, T., Expression of bone morphogenetic protein 2, 4, 5, and 7 correlates with histological activity of otosclerotic foci (2012) Acta Otolaryngol., 132, pp. 624-631 | ||
| 504 | |a Schrauwen, I., Thys, M., Vanderstraeten, K., Fransen, E., Dieltjens, N., Huyghe, J.R., Ealy, M., Van Camp, G., Association of bone morphogenetic proteins with otosclerosis (2008) J. Bone Miner. Res., 23, pp. 507-516 | ||
| 504 | |a Chole, R.A., McKenna, M., Pathophysiology of otosclerosis (2001) Ontol. Neurotol., 22, pp. 249-257 | ||
| 504 | |a Stankovic, K.M., Adachi, O., Tsuji, K., Kristiansen, A.G., Adams, J.C., Rosen, V., Differences in gene expression between the otic capsule and other bones (2010) Hear. Res., 265, pp. 83-89 | ||
| 504 | |a Karosi, T., Sziklai IEtiopathogenesis of otosclerosis (2010) Eur. Arch. Otorhinolaryngol., 267, pp. 1337-1349 | ||
| 504 | |a Schrauwen, I., Van Camp, G., The etiology of otosclerosis: A combination of genes and environment (2010) Laryngoscope, 120, pp. 1195-1202 | ||
| 504 | |a Niedermeyer, H.P., Gantumur, T., Neubert, W.J., Arnold, W., Measles virus and otosclerosis (2007) Adv. Otorhinolaryngol., 65, pp. 86-92 | ||
| 504 | |a Karosi, T., Jókay, I., Kónya, J., Petkó, M., Szabó, L.Z., Sziklai, I., Expression of measles virus receptors in otosclerotic, non-otosclerotic and in normal stapes footplates (2007) Eur. Arch. Otorhinolaryngol., 264, pp. 607-613 | ||
| 504 | |a Linero, F.N., Scolaro, L.A., Participation of the phosphatidylinositol 3-kinase/AKTpathway in Junín virus replication in vitro (2009) Virus Res., 145, pp. 166-170 | ||
| 504 | |a Gardner, C., Burke, C.W., Tesfay, M.Z., Glass, P.J., Klimstra, W.B., Ryman, K.D., Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: Impact of altered cell tropism on pathogenesis (2008) J. Virol., 82, pp. 10634-10646 | ||
| 504 | |a Vogel, P., Kell, W.M., Fritz, D.L., Parker, M.D., Schoepp, R.J., Early events in the pathogenesis of eastern equine encephalitis virus in mice (2005) Am. J. Pathol., 166, pp. 159-171 | ||
| 504 | |a Chen, W., Foo, S.S., Rulli, N.E., Taylor, A., Sheng, K.C., Herrero, L.J., Herring, B.L., Mahalingam, S., Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss (2014) Proc. Natl. Acad. Sci., 111, pp. 6040-6045 | ||
| 504 | |a Liu, W., Butts, S., Kim, H., Frenz, D.A., Negative regulation of otic capsule chondrogenesis: It can make you Smad (2007) Ann. N. Y. Acad. Sci., 1116, pp. 141-148 | ||
| 504 | |a Sánchez-Capelo, A., Dual role for TGF-beta1 in apoptosis (2005) Cytokine Growth Factor Rev., 16, pp. 15-34 | ||
| 504 | |a McKenna, M.J., Kristiansen, A.G., Bartley, M.L., Rogus, J.J., Haines, J.L., Association of COL1A1 and otosclerosis: Evidence for a shared genetic etiology with mild osteogenesis imperfecta (1998) Am. J. Otol., 19, pp. 604-610 | ||
| 504 | |a Karosi, T., Jókay, I., Kónya, J., Petkó, M., Szabó, L.Z., Pytel, J., Activated osteoclasts with CD51/61 expression in otosclerosis (2006) Laryngoscope, 116, pp. 1478-1484 | ||
| 504 | |a Zehnder, A.F., Kristiansen, A.G., Adams, J.C., Merchant, S.N., McKenna, M.J., Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule (2005) Laryngoscope, 115, pp. 172-177 | ||
| 504 | |a Carsillo, M., Kim, D., Niewiesk, S., Role of AKT kinase in measles virus replication (2010) J. Virol., 84, pp. 2180-2183 | ||
| 504 | |a Avota, E., Avots, A., Niewiesk, S., Kane, L.P., Bommhardt, U., Ter Meulen, V.S.-S.S., Disruption of AKT kinase activation is important for immunosuppression induced by measles virus (2001) Nat. Med., 7, pp. 725-731 | ||
| 504 | |a Niewiesk, S., Schneider-Schaulies, J., Ohnimus, H., Jassoy, C., Schneider-Schaulies, S., Diamond, L., Logan, J.S., Ter Meulen, V., CD46 expression does not overcome the intracellular block of measles virus replication in transgenic rats (1997) J. Virol., 71, pp. 7969-7973 | ||
| 504 | |a Schlender, J., Schnorr, J., Cattomen, T., Cattaneo, R., Billeter, M.A., Ter Meulen, V., Schneider-Schaulies, S., Surface interaction of measles virus glycoproteins is necessary and sufficient for the induction of proliferative inhibition of human peripheral blood mononuclear cells (1996) Proc. Natl. Acad. Sci., 93, pp. 13194-13199 | ||
| 520 | 3 | |a In this work we characterized the infection of a primary culture of rat osteoblastic lineage cells (OBCs) with measles virus (MeV) and the effect of infection on cell differentiation and maturation. Infection of OBCs with MeV led to high titers of infectivity released early after infection. Also, analysis of mRNAs corresponding to osteogenic differentiation markers like alkaline phosphatase (ALP), bone sialo-protein (BSP) and bone morphogenetic proteins (BMPs) 1-4-5-7 in OBCs revealed higher values (2-75-fold of increment) for infected cells in comparison with uninfected controls. Differentiation of OBCs in osteogenic medium prior to infection influenced the level of stimulation induced by MeV. Furthermore, treatment of OBCs with Ly294002, a PI3K/AKT inhibitor, increased viral titers, whereas treatment with 10 μM or 100 μM ATPγS diminished MeV multiplication. In addition, increments of osteogenic differentiation markers induced by MeV infection were not modified either by treatment with Ly294002 or ATPγS. These data provide the first evidence demonstrating that MeV can infect osteoblasts in vitro leading to osteoblastic differentiation, a key feature in bone pathogenic processes like otosclerosis. © 2014 Elsevier Inc. |l eng | |
| 536 | |a Detalles de la financiación: Universidad Nacional del Sur, 20020110100128BA | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 112-200901-00551, PGI 24/B211, 11220090100443CO | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: V.A.P. is a fellowship from Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET). G.S. and L.S. are members of the Research Career from CONICET (Argentina). This research was supported by Grants PIP 112-200901-00551 and 11220090100443CO from CONICET to G.S. and L.S., respectively, and PGI 24/B211 from Universidad Nacional del Sur to G.S. and 20020110100128BA from Universidad de Buenos Aires to L.S. | ||
| 593 | |a Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional Del sur, San Juan 670, (B8000ICN), Bahía Blanca, Argentina | ||
| 593 | |a Laboratorio de Virología, Departamento de Química Biológica, Universidad de Buenos Aires, Pabellón 2, Piso 4, Buenos Aires, 1428, Argentina | ||
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEINS |
| 690 | 1 | 0 | |a DIFFERENTIATION |
| 690 | 1 | 0 | |a MEASLES VIRUS |
| 690 | 1 | 0 | |a OSTEOBLASTS |
| 690 | 1 | 0 | |a OTOSCLEROSIS |
| 690 | 1 | 0 | |a 2 MORPHOLINO 8 PHENYLCHROMONE |
| 690 | 1 | 0 | |a ADENOSINE TRIPHOSPHATE |
| 690 | 1 | 0 | |a ALKALINE PHOSPHATASE |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN 4 |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN 5 |
| 690 | 1 | 0 | |a BONE SIALO PROTEIN |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a OSTEOGENIC PROTEIN 1 |
| 690 | 1 | 0 | |a PHOSPHATIDYLINOSITOL 3 KINASE |
| 690 | 1 | 0 | |a PROCOLLAGEN C PROTEINASE |
| 690 | 1 | 0 | |a PROTEIN |
| 690 | 1 | 0 | |a PROTEIN KINASE B |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE |
| 690 | 1 | 0 | |a ADENOSINE 5' O (3 THIOTRIPHOSPHATE) |
| 690 | 1 | 0 | |a ADENOSINE 5'-O-(3-THIOTRIPHOSPHATE) |
| 690 | 1 | 0 | |a ADENOSINE TRIPHOSPHATE |
| 690 | 1 | 0 | |a ALKALINE PHOSPHATASE |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN 4 |
| 690 | 1 | 0 | |a CHROMONE DERIVATIVE |
| 690 | 1 | 0 | |a DRUG DERIVATIVE |
| 690 | 1 | 0 | |a MORPHOLINE DERIVATIVE |
| 690 | 1 | 0 | |a PHOSPHATIDYLINOSITOL 3 KINASE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BONE DEVELOPMENT |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EXPERIMENTAL INFECTION |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a MEASLES |
| 690 | 1 | 0 | |a MEASLES VIRUS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OSTEOBLAST |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a STIMULATION |
| 690 | 1 | 0 | |a VIRUS LOAD |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a BONE |
| 690 | 1 | 0 | |a CELL CULTURE |
| 690 | 1 | 0 | |a DIFFERENTIATION |
| 690 | 1 | 0 | |a DRUG ANTAGONISM |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a OTOSCLEROSIS |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a VIROLOGY |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEINS |
| 690 | 1 | 0 | |a DIFFERENTIATION |
| 690 | 1 | 0 | |a MEASLES VIRUS |
| 690 | 1 | 0 | |a OSTEOBLASTS |
| 690 | 1 | 0 | |a OTOSCLEROSIS |
| 690 | 1 | 0 | |a ADENOSINE TRIPHOSPHATE |
| 690 | 1 | 0 | |a ALKALINE PHOSPHATASE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BONE AND BONES |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN 4 |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELLS, CULTURED |
| 690 | 1 | 0 | |a CHROMONES |
| 690 | 1 | 0 | |a MEASLES VIRUS |
| 690 | 1 | 0 | |a MORPHOLINES |
| 690 | 1 | 0 | |a OSTEOBLASTS |
| 690 | 1 | 0 | |a OTOSCLEROSIS |
| 690 | 1 | 0 | |a PHOSPHATIDYLINOSITOL 3-KINASES |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 650 | 1 | 7 | |2 spines |a OSTEOGENESIS |
| 700 | 1 | |a Santillán, G. | |
| 700 | 1 | |a Scolaro, L. | |
| 773 | 0 | |d Academic Press Inc., 2014 |g v. 451 |h pp. 609-614 |k n. 4 |p Biochem. Biophys. Res. Commun. |x 0006291X |w (AR-BaUEN)CENRE-905 |t Biochemical and Biophysical Research Communications | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908390115&doi=10.1016%2fj.bbrc.2014.08.027&partnerID=40&md5=176d42b39ea2b1345b8e0c3be31a6b67 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.bbrc.2014.08.027 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0006291X_v451_n4_p609_AyalaPena |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v451_n4_p609_AyalaPena |y Registro en la Biblioteca Digital |
| 961 | |a paper_0006291X_v451_n4_p609_AyalaPena |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 84766 | ||