Novel therapeutic targets for arenavirus hemorrhagic fevers

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Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several th...

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Autor principal: Garca, C.C
Otros Autores: Seplveda, C.S, Damonte, E.B
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2011
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VIRUS RNA
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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100 1 |a Garca, C.C. 
245 1 0 |a Novel therapeutic targets for arenavirus hemorrhagic fevers 
260 |c 2011 
270 1 0 |m Damonte, E. B.; Laboratorio de Virologa, Departamento de Qumica Biolgica, Universidad de Buenos Aires, Pabelln 2, 1428 Buenos Aires, Argentina; email: edamonte@qb.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd.  |l eng 
593 |a Laboratorio de Virologa, Departamento de Qumica Biolgica, Universidad de Buenos Aires, Pabelln 2, 1428 Buenos Aires, Argentina 
690 1 0 |a ANTIVIRAL AGENT 
690 1 0 |a ARENAVIRUS 
690 1 0 |a JUNIN VIRUS 
690 1 0 |a LASSA VIRUS 
690 1 0 |a THERAPEUTIC TARGET 
690 1 0 |a VIRAL HEMORRHAGIC FEVERS 
690 1 0 |a ACRIDONE DERIVATIVE 
690 1 0 |a ANTIVIRUS AGENT 
690 1 0 |a BRASSINOSTEROID 
690 1 0 |a CANDID 1 
690 1 0 |a CELL ENZYME 
690 1 0 |a CHOLESTEROL 
690 1 0 |a DISULFIRAM 
690 1 0 |a EPIANDROSTERONE 
690 1 0 |a ESCRT PROTEIN 
690 1 0 |a FATTY ACID 
690 1 0 |a FAVIPIRAVIR 
690 1 0 |a FLUOROURACIL 
690 1 0 |a N MYRISTOLYLTRANSFERASE 
690 1 0 |a PHOSPHATIDYLSERINE 
690 1 0 |a PRASTERONE 
690 1 0 |a RIBAVIRIN 
690 1 0 |a ST 193 
690 1 0 |a ST 194 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a VIRUS PROTEIN 
690 1 0 |a VIRUS VACCINE 
690 1 0 |a VIRUS Z PROTEIN 
690 1 0 |a ARENAVIRUS HEMORRHAGIC FEVER 
690 1 0 |a ARGENTINE HEMORRHAGIC FEVER 
690 1 0 |a ARTICLE 
690 1 0 |a DRUG TARGETING 
690 1 0 |a HUMAN 
690 1 0 |a INFECTION CONTROL 
690 1 0 |a JUNIN VIRUS 
690 1 0 |a LASSA VIRUS 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a VIRION 
690 1 0 |a VIRUS ENVELOPE 
690 1 0 |a VIRUS GENOME 
690 1 0 |a VIRUS HEMORRHAGIC FEVER 
690 1 0 |a ARENAVIRIDAE 
690 1 0 |a ARENAVIRUS 
690 1 0 |a JUNIN VIRUS 
690 1 0 |a LASSA VIRUS 
650 1 7 |2 spines  |a VIRUS RNA 
700 1 |a Seplveda, C.S. 
700 1 |a Damonte, E.B. 
773 0 |d 2011  |g v. 6  |h pp. 27-44  |k n. 1  |p Future Virol.  |x 17460794  |t Future Virology 
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