Key questions in metastasis: New insights in molecular pathways and therapeutic implications

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The metastatic cascade and colonization remains a major challenge in clinical therapeutics. The formation ofmetastasis has many rate limiting steps. The expression of metastases initiation genes in primary tumors is driven by theneed for cell motility, invasiveness, handling the shear stress in the...

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Autor principal: Gueron, G.
Otros Autores: de Siervi, A., Vazquez, E.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Bentham Science Publishers B.V. 2011
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Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
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100 1 |a Gueron, G. 
245 1 0 |a Key questions in metastasis: New insights in molecular pathways and therapeutic implications 
260 |b Bentham Science Publishers B.V.  |c 2011 
270 1 0 |m Vazquez, E.; Department of Biological Chemistry, School of Sciences, University of Buenos Aires, Ciudad Universitaria, Pabellon II, 2do Piso (1428), Buenos Aires, Argentina; email: elba@qb.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a The metastatic cascade and colonization remains a major challenge in clinical therapeutics. The formation ofmetastasis has many rate limiting steps. The expression of metastases initiation genes in primary tumors is driven by theneed for cell motility, invasiveness, handling the shear stress in the vasculature and lymphatic circulation, and the survivaland persistent growth in the distant organ. However, the expression of the progression genes in the primary tumors has amore complex basis. These metastasis-prone genes support primary tumor growth through one particular effect, whereasthey enhance distant metastasis through another effect. The boundaries between metastasis initiation and metastasis progressiongenes are not rigid. In this review, we examine novel gene signatures identified in metastases, address key inflammatoryfactors mastering homing selection, gain further mechanistic insights into cell plasticity and evaluate the roleof microRNAs. Moreover, we also describe the recent progress in developing nanoparticle imaging substantiating a promisingtheranostic platform for future cancer diagnostics and treatment, and assess the relevance of the bioinformatic analysisof metastasis-related proteins with an eye toward the metastatic niche. All these tools will provide valuable biologicalinformation of the progression of the disease, helping find potential therapeutic targets and improving surgical procedures.In a near future the understanding of the molecular mechanisms in tumor dissemination will be pivotal for the translationof these methods to the clinic and will help to overcome the barriers in clinical therapy of metastases. © 2011 Bentham Science Publishers.  |l eng 
593 |a Department of Biological Chemistry, School of Sciences, University of Buenos Aires, Ciudad Universitaria, Pabellon II, 2do Piso (1428), Buenos Aires, Argentina 
690 1 0 |a EPITHELIAL-MESENCHYMAL-TRANSITION 
690 1 0 |a GENE-SIGNATURE 
690 1 0 |a INFLAMMATION 
690 1 0 |a METASTASIS 
690 1 0 |a MICRORNA 
690 1 0 |a THERAPY 
690 1 0 |a VASCULAR MIMICRY 
690 1 0 |a ANTINEOPLASTIC AGENT 
690 1 0 |a BETA CATENIN 
690 1 0 |a CHEMOKINE RECEPTOR CXCR4 
690 1 0 |a CYCLOPHOSPHAMIDE 
690 1 0 |a CYTOKINE 
690 1 0 |a EPIDERMAL GROWTH FACTOR 
690 1 0 |a EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78 
690 1 0 |a ETOPOSIDE 
690 1 0 |a GALECTIN 3 
690 1 0 |a GELATINASE B 
690 1 0 |a INTERLEUKIN 6 
690 1 0 |a INTERLEUKIN 8 
690 1 0 |a MICRORNA 
690 1 0 |a MONOCLONAL ANTIBODY 
690 1 0 |a NANOPARTICLE 
690 1 0 |a PLATELET DERIVED GROWTH FACTOR 
690 1 0 |a PREDNISONE 
690 1 0 |a PROCARBAZINE 
690 1 0 |a PROTEIN P53 
690 1 0 |a PROTEIN TYROSINE KINASE INHIBITOR 
690 1 0 |a RITUXIMAB 
690 1 0 |a SCATTER FACTOR 
690 1 0 |a STAT1 PROTEIN 
690 1 0 |a THALIDOMIDE 
690 1 0 |a TRANSFORMING GROWTH FACTOR BETA 
690 1 0 |a TRASTUZUMAB 
690 1 0 |a UVOMORULIN 
690 1 0 |a VASCULOTROPIN A 
690 1 0 |a VASCULOTROPIN D 
690 1 0 |a VASCULOTROPIN RECEPTOR 3 
690 1 0 |a ANAEROBIC GLYCOLYSIS 
690 1 0 |a ANGIOGENESIS 
690 1 0 |a BONE METASTASIS 
690 1 0 |a BREAST CANCER 
690 1 0 |a CANCER GROWTH 
690 1 0 |a CELL HOMING 
690 1 0 |a COLORECTAL CANCER 
690 1 0 |a EPITHELIAL MESENCHYMAL TRANSITION 
690 1 0 |a GENE EXPRESSION 
690 1 0 |a HUMAN 
690 1 0 |a MANTLE CELL LYMPHOMA 
690 1 0 |a METASTASIS 
690 1 0 |a NONHUMAN 
690 1 0 |a RECURRENT CANCER 
690 1 0 |a REVIEW 
690 1 0 |a TUMOR MICROENVIRONMENT 
653 0 0 |a herceptin 
700 1 |a de Siervi, A. 
700 1 |a Vazquez, E. 
773 0 |d Bentham Science Publishers B.V., 2011  |g v. 12  |h pp. 1867-1880  |k n. 11  |p Curr. Pharm. Biotechnol.  |x 13892010  |t Current Pharmaceutical Biotechnology 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-81855216066&doi=10.2174%2f138920111798376996&partnerID=40&md5=a36ce01823f584913e3eb1462db9ffbd  |y Registro en Scopus 
856 4 0 |u https://doi.org/10.2174/138920111798376996  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_13892010_v12_n11_p1867_Gueron  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13892010_v12_n11_p1867_Gueron  |y Registro en la Biblioteca Digital 
961 |a paper_13892010_v12_n11_p1867_Gueron  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 84701 

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