Progesterone effects on neuronal brain-derived neurotrophic factor and glial cells during progression of Wobbler mouse neurodegeneration

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Previous results have shown a depletion of brain-derived neurotrophic factor (BDNF) mRNA in the degenerating motoneurons from clinically afflicted Wobbler mice, whereas progesterone treatment reverts this depletion. We now compared progesterone regulation of BDNF in motoneurons and oligodendrocytes...

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Autor principal: Meyer, M.
Otros Autores: Gonzalez Deniselle, M.C, Gargiulo-Monachelli, G., Garay, L.I, Schumacher, M., Guennoun, R., De Nicola, A.F
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2012
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-84855543553 
024 7 |2 cas  |a brain derived neurotrophic factor, 218441-99-7; progesterone, 57-83-0; Brain-Derived Neurotrophic Factor; Progesterone, 57-83-0; RNA, Messenger; Vesicular Transport Proteins; Vps54 protein, mouse 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a NRSCD 
100 1 |a Meyer, M. 
245 1 0 |a Progesterone effects on neuronal brain-derived neurotrophic factor and glial cells during progression of Wobbler mouse neurodegeneration 
260 |c 2012 
270 1 0 |m De Nicola, A.F.; Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina; email: alejandrodenicola@gmail.com 
506 |2 openaire  |e Política editorial 
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520 3 |a Previous results have shown a depletion of brain-derived neurotrophic factor (BDNF) mRNA in the degenerating motoneurons from clinically afflicted Wobbler mice, whereas progesterone treatment reverts this depletion. We now compared progesterone regulation of BDNF in motoneurons and oligodendrocytes of Wobbler mice at the progressive (EP, 1-3 months), symptomatic (SYM, 5-8 months old), and late stages (LS, 12-13 months). As controls we used NFR/NFR mice. Controls and Wobbler mice of different ages remained untreated or received a 20 mg progesterone pellet during 18 days. BDNF mRNA was determined in the ventral, intermediolateral, and dorsal gray matter by film autoradiography and in motoneurons using in situ hybridization. A depletion of BDNF mRNA already occurred at the EP stage of Wobblers, but progesterone was inactive at this period. In contrast, progesterone upregulated the low levels of BDNF mRNA in SYM Wobblers in the three gray matter regions analyzed. Progesterone also increased BDNF mRNA in LS Wobblers, according to grain counting procedures. BDNF protein analyzed by enzyme-linked immunosorbent assay (ELISA) in ventral horns or immunostaining of motoneurons was normal in steroid-naive SYM Wobblers. BDNF protein was decreased by progesterone, suggesting increased anterograde transport and/or release of neuronal BDNF. Wobbler mice also showed depletion of CC1-immunopositive oligodendrocytes, whereas progesterone treatment enhanced the density of BDNF+ and CC1+ oligodendrocytes in EP, SYM, and LS Wobblers. Our results suggest that BDNF could be involved in progesterone effects on motoneurons at the SYM and LS periods, whereas effects on oligodendrocytes occurred at all stages of the Wobbler disease. These steroid actions may be important to arrest the ongoing neurodegeneration. © 2011 IBRO.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires, M01 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 112-200801-00542 
536 |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica, PICT 2007 -01044 
536 |a Detalles de la financiación: This work was supported by FONCYT PICT 2007 -01044, CONICET (PIP 112-200801-00542 ), the University of Buenos Aires (M01), and a cooperative program INSERM/CONICET. 
593 |a Laboratory of Neuroendocrine Biochemistry, Instituto de Biología y Medicina Experimental-CONICET, Obligado 2490, 1428 Buenos Aires, Argentina 
593 |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, 1425 Buenos Aires, Argentina 
593 |a UMR788 Inserm and University Paris-Sud 11, 94276 Kremlin-Bicêtre, France 
690 1 0 |a BRAIN-DERIVED NEUROTROPHIC FACTOR 
690 1 0 |a MOTONEURON DEGENERATION 
690 1 0 |a NEUROPROTECTION 
690 1 0 |a OLIGODENDROCYTES 
690 1 0 |a PROGESTERONE 
690 1 0 |a WOBBLER MOUSE 
690 1 0 |a BRAIN DERIVED NEUROTROPHIC FACTOR 
690 1 0 |a PROGESTERONE 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL MODEL 
690 1 0 |a ANIMAL TISSUE 
690 1 0 |a ARTICLE 
690 1 0 |a ASTROCYTE 
690 1 0 |a AUTORADIOGRAPHY 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DISEASE COURSE 
690 1 0 |a ENZYME LINKED IMMUNOSORBENT ASSAY 
690 1 0 |a FEMALE 
690 1 0 |a GENE EXPRESSION 
690 1 0 |a GLIA CELL 
690 1 0 |a GRAY MATTER 
690 1 0 |a IMMUNOHISTOCHEMISTRY 
690 1 0 |a IN SITU HYBRIDIZATION 
690 1 0 |a MALE 
690 1 0 |a MOTONEURON 
690 1 0 |a MOUSE 
690 1 0 |a NERVE DEGENERATION 
690 1 0 |a NERVE FIBER TRANSPORT 
690 1 0 |a NONHUMAN 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN EXPRESSION 
690 1 0 |a SPINAL CORD VENTRAL HORN 
690 1 0 |a UPREGULATION 
690 1 0 |a AGE FACTORS 
690 1 0 |a ANIMALS 
690 1 0 |a BRAIN-DERIVED NEUROTROPHIC FACTOR 
690 1 0 |a DISEASE MODELS, ANIMAL 
690 1 0 |a DISEASE PROGRESSION 
690 1 0 |a ENZYME-LINKED IMMUNOSORBENT ASSAY 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a MICE 
690 1 0 |a MICE, NEUROLOGIC MUTANTS 
690 1 0 |a MOTOR NEURON DISEASE 
690 1 0 |a MUTATION 
690 1 0 |a NEUROGLIA 
690 1 0 |a NEURONS 
690 1 0 |a PROGESTERONE 
690 1 0 |a RNA, MESSENGER 
690 1 0 |a VESICULAR TRANSPORT PROTEINS 
700 1 |a Gonzalez Deniselle, M.C. 
700 1 |a Gargiulo-Monachelli, G. 
700 1 |a Garay, L.I. 
700 1 |a Schumacher, M. 
700 1 |a Guennoun, R. 
700 1 |a De Nicola, A.F. 
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