Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis

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In mice with experimental autoimmune encephalomyelitis (EAE) pretreatment with progesterone improves clinical signs and decreases the loss of myelin basic protein (MBP) and proteolipid protein (PLP) measured by immunohistochemistry and in situ hybridization. Presently, we analyzed if progesterone ef...

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Detalles Bibliográficos
Autor principal: Garay, L.I
Otros Autores: González Deniselle, M.C, Brocca, M.E, Lima, A., Roig, P., De Nicola, A.F
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2012
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 Molecular Sequence Numbers  |a GENBANK: NM_008337, NM_010851, NM_010919, NM_010927, NM_011609, NM_013693, NM_016967, NM_016968, NM_020529, NM_021274, NM_021297, NM_031168, NM_199478; 
024 7 |2 cas  |a progesterone, 57-83-0; toll like receptor 4, 203811-83-0; Aif1 protein, mouse; Calcium-Binding Proteins; Inflammation Mediators; Microfilament Proteins; Myelin Proteins; Progesterone, 57-83-0; RNA, Messenger; Transcription Factors 
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100 1 |a Garay, L.I. 
245 1 0 |a Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis 
260 |c 2012 
270 1 0 |m De Nicola, A.F.; Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Obligado 2490, 1428 Buenos Aires, Argentina; email: alejandrodenicola@gmail.com 
506 |2 openaire  |e Política editorial 
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504 |a Yu, H.J., Fei, J., Chen, X.S., Cai, Q.Y., Liu, H.L., Liu, G.D., Yao, Z.X., Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein (2010) Neurosci Lett, 476, pp. 42-45 
520 3 |a In mice with experimental autoimmune encephalomyelitis (EAE) pretreatment with progesterone improves clinical signs and decreases the loss of myelin basic protein (MBP) and proteolipid protein (PLP) measured by immunohistochemistry and in situ hybridization. Presently, we analyzed if progesterone effects in the spinal cord of EAE mice involved the decreased transcription of local inflammatory mediators and the increased transcription of myelin proteins and myelin transcription factors. C57Bl/6 female mice were divided into controls, EAE and EAE receiving progesterone (100. mg implant) 7. days before EAE induction. Tissues were collected on day 17 post-immunization. Real time PCR technology demonstrated that progesterone blocked the EAE-induced increase of the proinflammatory mediators tumor necrosis factor alpha (TNFα) and its receptor TNFR1, the microglial marker CD11b and toll-like receptor 4 (TLR4) mRNAs, and increased mRNA expression of PLP and MBP, the myelin transcription factors NKx2.2 and Olig1 and enhanced CC1. +. oligodendrocyte density respect of untreated EAE mice. Immunocytochemistry demonstrated decreased Iba1. +. microglial cells. Confocal microscopy demonstrated that TNFα colocalized with glial-fibrillary acidic protein. +. astrocytes and OX-42. +. microglial cells. Therefore, progesterone treatment improved the clinical signs of EAE, decreased inflammatory glial reactivity and increased myelination. Data suggest that progesterone neuroprotection involves the modulation of transcriptional events in the spinal cord of EAE mice. © 2012 IBRO.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires, 20020100100089 
536 |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica, PICT 2007-01044 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 112-200801-00542 
536 |a Detalles de la financiación: This work was supported by grants from FONCYT ( PICT 2007-01044 ), CONICET ( PIP 112-200801-00542 ) and the University of Buenos Aires ( 20020100100089 ). There are no conflicts of interests. 
593 |a Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Obligado 2490, 1428 Buenos Aires, Argentina 
593 |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, 1425 Buenos Aires, Argentina 
690 1 0 |a EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS 
690 1 0 |a MYELIN PROTEINS 
690 1 0 |a NEUROPROTECTION 
690 1 0 |a PROGESTERONE 
690 1 0 |a PROINFLAMMATORY MEDIATORS 
690 1 0 |a TRANSCRIPTION FACTORS 
690 1 0 |a AUTACOID 
690 1 0 |a CD11B ANTIGEN 
690 1 0 |a GLIAL FIBRILLARY ACIDIC PROTEIN 
690 1 0 |a MESSENGER RNA 
690 1 0 |a MYELIN BASIC PROTEIN 
690 1 0 |a PROGESTERONE 
690 1 0 |a PROTEIN OLIG1 
690 1 0 |a PROTEOLIPID PROTEIN 
690 1 0 |a TOLL LIKE RECEPTOR 4 
690 1 0 |a TRANSCRIPTION FACTOR 
690 1 0 |a TRANSCRIPTION FACTOR NKX2.2 
690 1 0 |a TUMOR NECROSIS FACTOR ALPHA 
690 1 0 |a TUMOR NECROSIS FACTOR RECEPTOR 1 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a ALLERGIC ENCEPHALOMYELITIS 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL MODEL 
690 1 0 |a ANIMAL TISSUE 
690 1 0 |a ARTICLE 
690 1 0 |a ASTROCYTE 
690 1 0 |a CONFOCAL MICROSCOPY 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DOWN REGULATION 
690 1 0 |a DRUG MECHANISM 
690 1 0 |a FEMALE 
690 1 0 |a IMMUNOCYTOCHEMISTRY 
690 1 0 |a IMMUNOHISTOCHEMISTRY 
690 1 0 |a IN SITU HYBRIDIZATION 
690 1 0 |a MICROGLIA 
690 1 0 |a MOUSE 
690 1 0 |a MYELINATION 
690 1 0 |a NONHUMAN 
690 1 0 |a NUCLEOTIDE SEQUENCE 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a PHARMACOLOGICAL BLOCKING 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN LOCALIZATION 
690 1 0 |a REAL TIME POLYMERASE CHAIN REACTION 
690 1 0 |a SPINAL CORD 
690 1 0 |a ANIMALS 
690 1 0 |a CALCIUM-BINDING PROTEINS 
690 1 0 |a DOWN-REGULATION 
690 1 0 |a ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL 
690 1 0 |a FEMALE 
690 1 0 |a IMMUNOHISTOCHEMISTRY 
690 1 0 |a INFLAMMATION MEDIATORS 
690 1 0 |a MICE 
690 1 0 |a MICE, INBRED C57BL 
690 1 0 |a MICROFILAMENT PROTEINS 
690 1 0 |a MICROGLIA 
690 1 0 |a MICROSCOPY, CONFOCAL 
690 1 0 |a MYELIN PROTEINS 
690 1 0 |a MYELIN SHEATH 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a PROGESTERONE 
690 1 0 |a REAL-TIME POLYMERASE CHAIN REACTION 
690 1 0 |a RNA, MESSENGER 
690 1 0 |a SPINAL CORD 
690 1 0 |a TRANSCRIPTION FACTORS 
700 1 |a González Deniselle, M.C. 
700 1 |a Brocca, M.E. 
700 1 |a Lima, A. 
700 1 |a Roig, P. 
700 1 |a De Nicola, A.F. 
773 0 |d 2012  |g v. 226  |h pp. 40-50  |p Neuroscience  |x 03064522  |w (AR-BaUEN)CENRE-759  |t Neuroscience 
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856 4 0 |u https://doi.org/10.1016/j.neuroscience.2012.09.032  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_03064522_v226_n_p40_Garay  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v226_n_p40_Garay  |y Registro en la Biblioteca Digital 
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