Neuronal plasticity and antidepressants in the diabetic brain
The hippocampus, a limbic structure linked to higher brain functions, appears vulnerable in diabetic subjects that have a higher risk of stroke, dementia, and cognitive decline. The dentate gyrus (DG) of the hippocampus is one of the limited neurogenic brain areas during adulthood; neurons born in t...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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Blackwell Publishing Inc.
2009
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12165caa a22013097a 4500 | ||
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| 003 | AR-BaUEN | ||
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| 008 | 190411s2009 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-60349127344 | |
| 024 | 7 | |2 cas |a fluoxetine, 54910-89-3, 56296-78-7, 59333-67-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ANYAA | ||
| 100 | 1 | |a Beauquis, J. | |
| 245 | 1 | 0 | |a Neuronal plasticity and antidepressants in the diabetic brain |
| 260 | |b Blackwell Publishing Inc. |c 2009 | ||
| 270 | 1 | 0 | |m Saravia, F.; Institute of Biology and Experimental Medicine, National Research Council (CONICET), Obligado 2490, 1428 Buenos Aires, Argentina; email: fsaravia@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The hippocampus, a limbic structure linked to higher brain functions, appears vulnerable in diabetic subjects that have a higher risk of stroke, dementia, and cognitive decline. The dentate gyrus (DG) of the hippocampus is one of the limited neurogenic brain areas during adulthood; neurons born in the DG are involved in some types of learning and memory processes. We found a decrease in the ability for proliferation and neuronal differentiation of newborn cells, measured by bromodeoxyuridine incorporation in the DG, from streptozotocin-induced diabetic mice. The hilar region, formed by mature neurons presenting higher sensitivity to brain damage, showed a reduced neuronal density in diabetic mice with respect to vehicle-treated mice. Interestingly, in a spontaneous model of type 1 diabetes, we corroborated a decrease in the rate of neurogenesis in the nonobese diabetic mice compared to control strains, and this reduction was also found during the prediabetic stage. The antidepressant fluoxetine administered over a period of 10 days to diabetic mice was effective in preventing changes in proliferation and differentiation of new neurons. Confocal microscope studies, including using neuronal and glial markers, suggested that differentiation toward a neuronal phenotype was decreased in diabetic animals and was reversed by the antidepressant treatment. In addition, the loss of hilar neurons was avoided by fluoxetine treatment. Several reports have demonstrated that high susceptibility to stress and elevated corticosterone levels are detrimental to neurogenesis and contribute to neuronal loss. These features are common in some types of depression, diabetes, and aging processes, suggesting they participate in the reported hippocampal abnormalities present in these conditions. © 2009 New York Academy of Sciences. |l eng | |
| 593 | |a Neuroendocrine Biochemistry, Institute of Biology and Experimental Medicine, National Research Council, Buenos Aires, Argentina | ||
| 593 | |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Institute of Biology and Experimental Medicine, National Research Council (CONICET), Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DENTATE GYRUS |
| 690 | 1 | 0 | |a FLUOXETINE |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a NEUROGENESIS |
| 690 | 1 | 0 | |a TYPE 1 DIABETES |
| 690 | 1 | 0 | |a ANTIDEPRESSANT AGENT |
| 690 | 1 | 0 | |a FLUOXETINE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a BRAIN DAMAGE |
| 690 | 1 | 0 | |a BRAIN DISEASE |
| 690 | 1 | 0 | |a CELL DENSITY |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CONFERENCE PAPER |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CORTICOSTERONE BLOOD LEVEL |
| 690 | 1 | 0 | |a DENTATE GYRUS |
| 690 | 1 | 0 | |a DIABETES MELLITUS |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a INSULIN DEPENDENT DIABETES MELLITUS |
| 690 | 1 | 0 | |a LIMBIC CORTEX |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NERVE CELL |
| 690 | 1 | 0 | |a NERVE CELL PLASTICITY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PHENOTYPE |
| 690 | 1 | 0 | |a STREPTOZOCIN DIABETES |
| 690 | 1 | 0 | |a STRESS |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a MUS |
| 700 | 1 | |a Roig, P. | |
| 700 | 1 | |a De Nicola, A.F. | |
| 700 | 1 | |a Saravia, F. | |
| 773 | 0 | |d Blackwell Publishing Inc., 2009 |g v. 1153 |h pp. 203-208 |p Ann. New York Acad. Sci. |x 00778923 |w (AR-BaUEN)CENRE-1541 |z 9781573317467 |t Annals of the New York Academy of Sciences | |
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