Steroid protection in aging and age-associated diseases
Neuroactive steroids are secretory products of peripheral endocrine glands that modulate a variety of brain functions. A close relationship between neuroactive steroid structure and function becomes most evident under pathological circumstances. On one side, overproduction of glucocorticoid and mine...
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2009
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| LEADER | 13472caa a22014057a 4500 | ||
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| 001 | PAPER-23277 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205456.0 | ||
| 008 | 190411s2009 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-57349192117 | |
| 024 | 7 | |2 cas |a argipressin, 113-79-1; corticosterone, 50-22-6; dexamethasone, 50-02-2; hydrocortisone, 50-23-7; Estradiol, 50-28-2; Glucocorticoids; Mineralocorticoids; Neuroprotective Agents | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EXGEA | ||
| 100 | 1 | |a De Nicola, A.F. | |
| 245 | 1 | 0 | |a Steroid protection in aging and age-associated diseases |
| 260 | |c 2009 | ||
| 270 | 1 | 0 | |m De Nicola, A.F.; Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina; email: denicola@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Baulieu, E.E., Robel, P., Schumacher, M., Neurosteroids: beginning of the story (2001) Int. Rev. Neurobiol., 46, pp. 1-32 | ||
| 504 | |a Behl, C., Estrogen as a neuroprotective hormone (2002) Nat. Rev. Neurosci., 3, pp. 433-442 | ||
| 504 | |a Brismar, T., Maurex, L., Cooray, G., Juntti-Berggren, L., Lindström, P., Ekberg, K., Adner, N., Andersson, S., Predictors of cognitive impairment in type 1 diabetes (2007) Psychoneuroendocrinology, 32, pp. 1041-1051 | ||
| 504 | |a Cameron, H.A., McKay, R.D., Restoring production of hippocampal neurons in old age (1999) Nat. Neurosci., 2, pp. 894-897 | ||
| 504 | |a Darnaudery, M., Perez-Martin, M., Belizaire, G., Maccari, S., Garcia-Segura, L.M., Insulin-like growth factor 1 reduces age-related disorders induced by prenatal stress in female rats (2006) Neurobiol. Aging, 27, pp. 119-127 | ||
| 504 | |a De Kloet, E.R., Derijk, R.H., Meijer, O.C., Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression? (2007) Nat. Clin. Pract. Endocrinol. Metab., 3, pp. 168-179 | ||
| 504 | |a De Nicola, A.F., Magariños, A.M., Foglia, V.G., Neuroendocrine regulation in experimental diabetes (Houssay Lecture) (1991) Diabetes, pp. 3-8. , Rifkin H., Colwell J.A., and Taylor S.I. (Eds), Elsevier Science Publishers | ||
| 504 | |a De Nicola, A.F., Saravia, F.E., Beauquis, J., Pietranera, L., Ferrini, M.G., Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function (2006) Front. Horm. Res., 35, pp. 157-168 | ||
| 504 | |a Ferrini, M., Piroli, G., Frontera, M., Falbo, A., Lima, A., De Nicola, A.F., Estrogens normalize the hypothalamic-pituitary-adrenal axis response to stress and increase glucocorticoid receptor immuno-reactivity in hippocampus of aging male rats (1999) Neuroendocrinology, 69, pp. 129-137 | ||
| 504 | |a Funder, J.W., Aldosterone, mineralocorticoid receptors and vascular inflammation (2004) Mol. Cell. Endocrinol., 217, pp. 263-269 | ||
| 504 | |a Garcia-Segura, L.M., Sanz, A., Mendez, P., Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection (2006) Neuroendocrinology, 84, pp. 275-279 | ||
| 504 | |a Goodman, Y., Bruce, A.J., Cheng, B., Mattson, M.P., Estrogens attenuate and CORT exacerbates excitotoxicity, oxidative injury, and amyloid β-peptide toxicity in hippocampal neurons (1996) J. Neurochem., 66, pp. 1836-1844 | ||
| 504 | |a Isgor, C., Watson, S.J., Estrogen receptor alpha and beta mRNA expressions by proliferating and differentiating cells in the adult rat dentate gyrus and subventricular zone (2005) Neuroscience, 134, pp. 847-856 | ||
| 504 | |a Kempermann, G., Gast, D., Gage, F.H., Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment (2000) Ann. Neurol., 52, pp. 135-143 | ||
| 504 | |a Lacreuse, A., Effects of ovarian hormones on cognitive function in nonhuman primates (2006) Neuroscience, 138, pp. 859-867 | ||
| 504 | |a Lephart, E.D., Galindo, E., Bu, L.H., Stress (hypothalamic-pituitary-adrenal axis) and pain response in male rats exposed lifelong to high vs. low phytoestrogen diets (2003) Neurosci. Lett., 342, pp. 65-68 | ||
| 504 | |a Liu, F., Day, M., Muñiz, L.C., Bitran, D., Arias, R., Revilla-Sanchez, R., Grauer, S., Brandon, N.J., Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory (2008) Nat. Neurosci., 11, pp. 334-343 | ||
| 504 | |a McEwen, B.S., Estrogen actions throughout the brain (2002) Rec. Progr. Horm. Res., 57, pp. 357-370 | ||
| 504 | |a Miller, D.B., O'Callaghan, J.P., Aging, stress and the hippocampus (2005) Ageing Res. Rev., 4, pp. 123-140 | ||
| 504 | |a Oomen, C.A., Mayer, J.L., de Kloet, E.R., Joëls, M., Lucassen, P.J., Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress (2007) Eur. J. Neurosci., 26, pp. 3395-3401 | ||
| 504 | |a Perez-Martin, M., Salazar, V., Castillo, C., Ariznavarreta, C., Azcoitia, I., Garcia-Segura, L.M., Tresguerres, J.A., Estradiol and soy extract increase the production of new cells in the dentate gyrus of old rats (2005) Exp. Gerontol., 40, pp. 450-453 | ||
| 504 | |a Petersen, R.C., Jack Jr., C.R., Xu, Y.C., Waring, S.C., O'Brien, P.C., Smith, G.E., Ivnik, R.J., Kokmen, E., Memory and MRI-based hippocampal volumes in aging and AD (2000) Neurology, 54, pp. 581-587 | ||
| 504 | |a Pietranera, L., Saravia, F., Gonzalez Deniselle, M.C., Roig, P., Lima, A., De Nicola, A.F., Abnormalities of the hippocampus are similar in deoxycorticosterone acetate-salt hypertensive rats and spontaneously hypertensive rats (2006) J. Neuroendocrinol., 18, pp. 466-474 | ||
| 504 | |a Pietranera, L., Saravia, F.E., Roig, P., Lima, A., De Nicola, A.F., Protective effects of estradiol in the brain of rats with genetic or mineralocorticoid-induced hypertension (2008) Psychoneuroendocrinology, 33, pp. 270-281 | ||
| 504 | |a Rahmouni, K., Barthelmebs, M., Grima, M., Imbs, J.L., De Jong, W., Involvement of brain mineralocorticoid receptor in salt-enhanced hypertension in spontaneously hypertensive rats (2001) Hypertension, 38, pp. 902-906 | ||
| 504 | |a Resnick, S.M., Maki, P.M., Rapp, S.R., Espeland, M.A., Brunner, R., Coker, L.H., Granek, I.A., Shumaker, S.A., Women's health initiative study of cognitive aging investigators. effects of combination estrogen plus progestin hormone treatment on cognition and affect (2006) J. Clin. Endocrinol. Metab., 91, pp. 1802-1810 | ||
| 504 | |a Sapolsky, R., Krey, L.C., McEwen, B.S., The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis (1986) Endocr. Rev., 7, pp. 284-304 | ||
| 504 | |a Saravia, F.E., Beauquis, J., Pietranera, L., De Nicola, A.F., Neuroprotective effects of estradiol in the hippocampus of middle age mice: involvement of neurons and glial cells (2007) Psychoneuroendocrinology, 32, pp. 480-492 | ||
| 504 | |a Saravia, F., Revsin, Y., Lux-Lantos, V., Beauquis, J., Homo-Delarche, F., De Nicola, A.F., Oestradiol restores cell proliferation in dentate gryus and subventricular zone of streptozotocin-diabetic mice (2004) J. Neuroendocrinol., 16, pp. 704-710 | ||
| 504 | |a Scharfman, H.E., Maclusky, N.J., Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue? (2005) Trends Neurosci., 28, pp. 79-85 | ||
| 504 | |a Sherwin, B.B., Henry, J.F., Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review (2008) Front. Neuroendocrinol., 29, pp. 88-113 | ||
| 504 | |a Shughrue, P.J., Lane, M.V., Merchentaler, I., Comparative distribution of estrogen receptor α and β mRNA in the rat central nervous system (1997) J. Comp. Neurol., 388, pp. 507-525 | ||
| 504 | |a Smith, R.G., Betancourt, L., Sun, Y., Molecular endocrinology and physiology of the aging central nervous system (2005) Endocr. Rev., 26, pp. 203-250 | ||
| 504 | |a Tanapat, P., Hastings, N.B., Gould, E., Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose- and time-dependent manner (2005) J. Comp. Neurol., 481, pp. 252-265 | ||
| 504 | |a Verret, L., Trouche, S., Zerwas, M., Rampon, C., Hippocampal neurogenesis during normal and pathological aging (2007) Psychoneuroendocrinology, 32 (SUPPL. 1), pp. S26-S30 | ||
| 504 | |a Wong, E.Y.H., Herbert, J., Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus (2005) Eur. J. Neurosci., 22, pp. 785-792 | ||
| 520 | 3 | |a Neuroactive steroids are secretory products of peripheral endocrine glands that modulate a variety of brain functions. A close relationship between neuroactive steroid structure and function becomes most evident under pathological circumstances. On one side, overproduction of glucocorticoid and mineralocorticoid neuroactive steroids may be detrimental to the hippocampus, which is enriched in glucocorticoid receptors (GR) and mineralocorticoid receptors (MR). Thus, a dysfunction of the adrenocortical system in aging and age-associated diseases (diabetes, hypertension) is able to cause hippocampal damage. Whereas aging and uncontrolled diabetes show a predominant GR overdrive, a MR overdrive characterizes hypertensive animals. Some abnormalities commonly found in the hippocampus of aging, diabetic and hypertensive animals include decreased neurogenesis, astrogliosis and neuronal loss in the hilus of the dentate gyrus (DG). On the other side, and in contrast to adrenal gland-derived steroids, estrogens qualify as hippocampal neuroprotectants. Given to middle-age mice, estrogens stimulated proliferation and differentiation of newborn cells in the DG, decreased astrogliosis and increased hilar neuronal number. Similar estrogen effects were obtained in mice with streptozotocin-induced diabetes and in spontaneously hypertensive rats (SHR). The results suggest that in aging and age-associated diseases, adrenocortical steroid overdrive sensitizes the hippocampus to the pathological milieu imposed by a pre-existing degeneration or illness. In this setting, estradiol neuroprotection rescues hippocampal parameters previously altered by the pathological environment. © 2008 Elsevier Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, M022 | ||
| 536 | |a Detalles de la financiación: National Council for Scientific Research | ||
| 536 | |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica, BID 1728 OC AR PICT 2004 25610 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 5542 | ||
| 536 | |a Detalles de la financiación: We thank the following institutions for financial support: FONCYT (BID 1728 OC AR PICT 2004 25610), the National Research Council of Argentina (CONICET, PIP 5542) and the University of Buenos Aires (M022). | ||
| 593 | |a Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 593 | |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Argentina | ||
| 593 | |a Division of Urology, Harbor-UCLA Medical Center, Torrance, CA 90502, United States | ||
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