Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration

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Studies on the neuroprotective and promyelinating effects of progesterone in the nervous system are of great interest due to their potential clinical connotations. In peripheral neuropathies, progesterone and reduced derivatives promote remyelination, axonal regeneration and the recovery of function...

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Autor principal: De Nicola, A.F
Otros Autores: Labombarda, F., Deniselle, M.C.G, Gonzalez, S.L, Garay, L., Meyer, M., Gargiulo, G., Guennoun, R., Schumacher, M.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2009
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-67349166912 
024 7 |2 cas  |a 20alpha dihydroprogesterone, 145-14-2; 3alpha hydroxy 5alpha pregnan 20 one, 516-54-1; brain derived neurotrophic factor, 218441-99-7; choline acetyltransferase, 9012-78-6; medroxyprogesterone acetate, 71-58-9; progesterone, 57-83-0; Brain-Derived Neurotrophic Factor; Neuroprotective Agents; Receptors, Progesterone 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a FNEDA 
100 1 |a De Nicola, A.F. 
245 1 0 |a Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration 
260 |c 2009 
270 1 0 |m De Nicola, A.F.; Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Obligado 2490, 1428 Buenos Aires, Argentina; email: denicola@dna.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a Ankeny, D.P., McTigue, D.M., Guan, Z., Yan, Q., Kinstler, O., Stokes, B.T., Jakeman, L.B., Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury (2001) Exp. Neurol., 170, pp. 85-100 
504 |a Arnett, H.A., Fancy, S.P.J., Alberta, J.A., Zhao, C., Plant, S.R., Kaing, S., Raine, C.S., Stiles, C.D., bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS (2004) Science, 306, pp. 2111-2115 
504 |a Aupperlee, M.D., Drolet, A.A., Durairaj, S., Wang, W., Schwartz, R.C., Haslam, S.Z., Strain-specific differences in the mechanisms of progesterone regulation of murine mammary gland development (2008) Endocrinology 
504 |a Azcoitia, I., Leonelli, E., Magnaghi, V., Veiga, S., Garcia Segura, L.M., Melcangi, R., Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats (2003) Neurobiol. Aging, 24, pp. 853-860 
504 |a Baulieu, E.E., Neurosteroids: of the nervous system, by the nervous system, for the nervous system (1997) Rec. Progr. Horm. Res., 52, pp. 1-31 
504 |a Baumann, N., Pham-Dinh, D., Biology of oligodendrocyte and myelin in the mammalian central nervous system (2001) Physiol. Rev., 81, pp. 871-927 
504 |a Bayir, H., Marion, D.W., Puccio, A.M., Wisniewski, S.R., Janesko, K.L., Clark, R.S., Kochanek, P.M., Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients (2004) J. Neurotrauma, 21, pp. 1-8 
504 |a Beattie, M.S., Farooqui, A.A., Bresnahan, J.E., Review of current evidence for apoptosis after spinal cord injury (2000) J. Neurotrauma, 17, pp. 915-923 
504 |a Beck, T., Lindholm, D., Castrén, E., Wree, A., BDNF protects against ischemia cell damage in rat hippocampus (1994) J. Cereb. Blood Flow Metab., 14, pp. 689-692 
504 |a Bigini, P., Bastone, A., Mennini, T., Glutamate transporters in the spinal cord of the Wobbler mouse (2001) Neuroreport, 12, pp. 1815-1820 
504 |a Blondet, B., Barlovatz-Meimon, G., Festoff, B.W., Soria, C., Soria, J., Rieger, F., Hantai, D., Plasminogen activator in the neuromuscular system of the Wobbler mutant mouse (1992) Brain Res., 580, pp. 303-310 
504 |a Boillée, S., Peschanski, M., Junier, M.-P., The Wobbler mouse: a neurodegeneration jigsaw puzzle (2003) Mol. Neurobiol., 28, pp. 65-106 
504 |a Boonyaratanakornkit, V., Bi, Y., Rudd, M., Edwards, D.P., The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression (2008) Steroids, 73, pp. 922-928 
504 |a Bramlett, H.M., Dietrich, W.D., Pathophysiology of cerebral ischemia and brain trauma: similarities and differences (2004) J. Cereb. Blood Flow. Metab., 24, pp. 133-150 
504 |a Bramlett, H.M., Dietrich, W.D., Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies (2007) Prog. Brain Res., 161, pp. 125-141 
504 |a Brinton, R.D., Thompson, R.F., Foy, M.R., Baudry, M., Wang, J., Finch, C.E., Morgan, T.E., Nilsen, J., Progesterone receptors: form and function in brain (2008) Front. Neuroendocrinol., 29, pp. 313-339 
504 |a Butenandt, A., Westphal, U., Isolation of progesterone - forty years ago (1974) Am. J. Obstet. Gynecol., 120, pp. 137-141 
504 |a Carr, B.R., Uniqueness of oral contraceptive progestins (1998) Contraception, 58, pp. 23S-27S 
504 |a Chan, J.R., Phillips, L.J., Glaser, M., Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation (1998) Proc. Natl. Acad. Sci., 95, pp. 10459-10464 
504 |a Chao, H.M., Spencer, R.L., Sakai, R.R., McEwen, B.S., The expression of growth-associated proein GAP-43 mRNA in the rat hippocampus in response to adrenalectomy and aging (1992) Mol. Cell. Neurosci., 3, pp. 529-535 
504 |a Chun, H., Son, J.J., Son, J.H., Identification of potential compounds promoting BDNF production in nigral dopaminergic neurons: clinical implications in Parkinsońs disease (2000) Neuroreport, 11, pp. 511-514 
504 |a Ciriza, I., Azcoitia, I., Garcia-Segura, L.M., Reduced progesterone metabolites protect rat hippocampal neurones from kainic acid excitotoxicity in vivo (2004) J. Neuroendocrinol., 16, pp. 58-63 
504 |a Clarke, P.G., Developmental cell death: morphological diversity and multiple mechanisms (1990) Anat. Embryol. (Berl), 181, pp. 195-213 
504 |a Clowry, G.J., McHanwell, S., Expression of nitric oxide synthase by motor neurons in the spinal cord of the mutant mouse Wobbler (1996) Neurosci. Lett., 215, pp. 177-180 
504 |a Cudkowicz, M.E., Brown, R.H., Amyotrophic lateral sclerosis and related motor neuron diseases (1998) Principles of Molecular Medicine, pp. 907-911. , Jameson J.L. (Ed), Humana Press, New Jersey 
504 |a Cutler, S.M., Vanlandingham, J.W., Stein, D.G., Tapered progesterone withdrawal promotes long-term recovery following brain trauma (2006) Exp. Neurol., 200, pp. 378-385 
504 |a Cutler, S.M., Pettus, E.H., Hoffman, S.W., Stein, D.G., Tapered progesterone withdrawal enhances behavioral and molecular recovery after traumatic brain injury (2005) Exp. Neurol., 195, pp. 423-429 
504 |a Cutler, S.M., VanLandingham, J.W., Murphy, A.Z., Stein, D.G., Slow-release and injected progesterone treatments enhance acute recovery after traumatic brain injury (2006) Pharmacol. Biochem. Behav., 84, pp. 420-428 
504 |a De Nicola, A.F., Steroid hormones and neuronal regeneration (1993) Adv. Neurol., 59, pp. 199-206 
504 |a De Nicola, A.F., Labombarda, F., Gonzalez, S.L., Gonzalez Deniselle, M.C., Guennoun, R., Schumacher, M., Steroid effects on glial cells: detrimental or protective for spinal cord function? (2003) Ann. NY Acad. Sci., 1007, pp. 317-328 
504 |a De Nicola, A.F., Gonzalez, S.L., Labombarda, F., Gonzalez Deniselle, M.C., Garay, L., Guennoun, R., Schumacher, M., Progesterone treatment of spinal cord injury: effects on receptors, neurotrophins, and myelination (2006) J. Mol. Neurosci., 28, pp. 3-15 
504 |a Dennis, J.S., Citron, B.A., Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein (2008) Neuroscience, 9 
504 |a Derfoul, A., Robertson, N., Lingrel, L., Hall, J., Litwack, R., Regulation of the human Na/K-ATPase (1 gene promoter by mineralocorticiod and glucocorticoid receptors (1998) J. Biol. Chem., 273, pp. 20702-20711 
504 |a Desarnaud F, F., Do Thi, A.N., Brown, A.M., Lemke, G., Suter U, U., Baulieu, E.E., Schumacher, M., Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells (1998) J. Neurochem., 71, pp. 1765-1768 
504 |a Djebaili, M., Hoffman, S.W., Stein, D.G., Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex (2004) Neuroscience, 123, pp. 349-359 
504 |a Djebaili, M., Guo, Q., Hoffman, S.W., Stein, D.G., The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury (2005) J. Neurotrauma, 22, pp. 106-118 
504 |a di Michele, F., Lekieffre, D., Pasini, A., Bernardi, G., Benavides, J., Romeo, E., Increased neurosteroids synthesis after brain and spinal cord injury in rats (2000) Neurosci. Lett., 284, pp. 65-68 
504 |a Di Stefano, G., Casoli, T., Fattoretti, P., Balietti, M., Grossi, Y., Giorgetti, B., Bertoni-Freddari, C., Level and distribution of microtubule-associated protein-2 (MAP2) as an index of dendritic structural dynamics (2006) Rejuvenation Res., 9, pp. 94-98 
504 |a Eidelberg, E., Nguyen, H., Polich, R., Walden, J.G., Transsynaptic degeneration of motoneurons caudal to spinal cord lesions (1989) Brain Res. Bull., 22, pp. 39-45 
504 |a (2005) Exp. Neurol., 195, pp. 518-523 
504 |a Fancy, S.P., Zhao, C., Franklin, R.J., Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS (2004) Mol. Cell. Neurosci., 27, pp. 247-254 
504 |a Farah, C.A., Liazoghli, D., Perreault, S., Desjardins, M., Guimont, A., Anton, A., Lauzon, M., Leclerc, N., Interaction of microtubule-associated protein-2 and p63: a new link between microtubules and rough endoplasmic reticulum membranes in neurons (2005) J. Biol. Chem., 280, pp. 9439-9449 
504 |a Farman, N., Bonvalet, J., Seckl, J., Aldosterone selectively increases Na/K ATPase (3-subunit mRNA expression in rat hippocampus (1994) Am. J. Physiol., 266, pp. C423-C428 
504 |a Fee, D.B., Swartz, K.R., Joy, K.M., Roberts, K.N., Scheff, N.N., Scheff SW, S.W., Effects of progesterone on experimental spinal cord injury (2007) Brain Res., 1137, pp. 146-152 
504 |a Franklin, R.J., Kotter, M.R., The biology of CNS remyelination: the key to therapeutic advances (2008) J. Neurol., 255 (SUPPL. 1), pp. 19-25 
504 |a Fukumitsu, H., Ohashi, A., Nitta, A., Nomoto, H., Furukawa, S., BDNF and NT-3 modulate expression and threonine phosphorylation of microtubule-associated protein 2 analogues, and alter their distribution in the developing rat cerebral cortex (1997) Neurosci. Lett., 238, pp. 107-110 
504 |a Gago, N., El-Etr, M., Sananès, N., Cadepond, F., Samuel, D., Avellana-Adalid, V., Baron-Van Evercooren, A., Schumacher, M., 3alpha,5alpha tetrahydroprogesterone (allopregnanolone) and gamma-aminobutyric acid: autocrine/paracrine interactions in the control of neonatal PSA-NCAM+ progenitor proliferation (1994) J. Neurosci. Res., 78, pp. 770-783 
504 |a Garay, L., Gonzalez Deniselle, M.C., Lima, A., Roig, P., De Nicola, A.F., Effects of progesterone in the spinal cord of a mouse model of multiple sclerosis (2007) J. Steroid Biochem. Mol. Biol., 107, pp. 228-237 
504 |a García-Estrada, J., Luquín, S., Fernández, A.M., Garcia-Segura, L.M., Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive astroglia in the male rat brain after a penetrating brain injury (1999) Int. J. Dev. Neurosci., 17, pp. 145-151 
504 |a Garcia-Segura, L.M., Melcangi, R.C., Steroids and glial cell function (2006) Glia, 54, pp. 485-498 
504 |a Ghoumari, A.M., Ibanez, C., El-Etr, M., Leclerc, F., Eychenne, B., Baulieu, E.E., Schumacher, M., Progesterone and its metabolites increase myelination in organotypic slice cultures of rat cerebellum (2003) J. Neurochem., 86, pp. 848-859 
504 |a Ghoumari, A.M., Baulieu, E.E., Schumacher, M., Progesterone increases oligodendroglial cell proliferation in rat cerebellar slice cultures (2005) Neuroscience, 135, pp. 47-58 
504 |a Gibson, C.L., Gray, L.J., Bath, P.M., Murphy, S.P., Progesterone for the treatment of experimental brain injury; a systematic review (2008) Brain, 131, pp. 318-328 
504 |a Giehl, K.M., Schutte, A., Mestres, P., Yan, Q., The survival-promoting effect of glial cell line-derived neurotrophic factor on axotomized corticospinal neurons in vivo is mediated by an endogenous brain-derived neurotrophic factor mechanism (1998) J. Neurosci., 18, pp. 7351-7360 
504 |a Gold, B.G., Mobley, .W.C., Matheson, S.F., Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor (1991) J. Neurosci., 11, pp. 943-955 
504 |a Gonzalez Deniselle, M.C., López-Costa, J.J., Saavedra, J.P., Pietranera, L., Gonzalez, S.L., Garay, L., Guennoun, R., De Incola, A.F., Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease (2002) Neurobiol. Dis., 211, pp. 457-468 
504 |a González Deniselle, M.C., López Costa, J.J., González, S., Labombarda, F., Garay, L., Guennoun, R., Schumacher, M., De Nicola, A.F., Basis of progesterone protection in spinal cord neurodegeneration (2003) J. Steroid Biochem. Mol. Biol., 83, pp. 199-209 
504 |a González Deniselle, M.C., Garay, L., López-Costa, J.J., González, S., Mougel, A., Guennoun, R., Schumacher, M., De Nicola, A.F., Progesterone treatment reduces NADPH-diaphorase/nitric oxide synthase in Wobbler mouse motoneuron disease (2004) Brain Res., 1014, pp. 71-79 
504 |a Gonzalez Deniselle, M.C., Garay, L., Gonzalez, S., Guennoun, R., Schumacher, M., De Nicola, A.F., Progesterone restores retrograde labeling of cervical motoneurons in Wobbler mouse motoneuron disease (2005) Exp. Neurol., 195, pp. 518-523 
504 |a Gonzalez Deniselle, M.C., Garay, L., Gonzalez, S., Saravia, F., Labombarda, F., Guennoun, R., Schumacher, M., De Nicola, A.F., Progesterone modulates brain-derived neurotrophic factor and choline acetyltransferase in degenerating Wobbler motoneurons (2007) Exp. Neurol., 203, pp. 406-414 
504 |a González, S.L., Labombarda, F., González Deniselle, M.C., Guennoun, R., Schumacher, M., De Nicola, A.F., Progesterone up-regulates neuronal brain-derived neurotrophic factor expression in the injured spinal cord (2004) Neurosci., 125, pp. 605-614 
504 |a Gonzalez, S.L., Labombarda, F., Gonzalez Deniselle, M.C., Mougel, A., Guennoun, R., Schumacher, M., De Nicola, A.F., Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneurons (2005) J. Steroid Biochem. Mol. Biol., 94, pp. 143-149 
504 |a González, S.L., López-Costa, J.J., Labombarda, F., Gonzalez Deniselle, M.C., Guennoun, R., Schumacher, M., De Nicola, A.F., Progesterone effects on neuronal ultrastructure and expression of microtubule-associated protein 2 (MAP2) in rats with acute spinal cord injury (2009) Cell. Mol. Neurobiol., 29, pp. 27-39 
504 |a Goss, C.W., Hoffman, S.W., Stein, D.G., Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study (2003) Pharmacol. Biochem. Behav., 76, pp. 231-242 
504 |a Graham, D.I., McIntosh, T.K., Maxwell, W.L., Nicoll, JA., Recent advances in neurotrauma (2002) J. Neuropathol. Exp. Neurol., 59, pp. 641-651 
504 |a Grossman, S.D., Rosenberg, L.J., Wrathall, J.R., Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion (2001) Exp. Neurol., 168, pp. 273-282 
504 |a Groswasser, Z., Cohen, M., Keren, O., Female TBI patients recover better than males (1998) Brain Inj., 12, pp. 805-808 
504 |a Guennoun, R., Benmessahel, Y., Delespierre, B., Gouezou, M., Rajkowski, K.M., Baulieu, E.E., Schumacher, M., Progesterone stimulates Krox-20 gene expression in Schwann cells (2001) Mol. Brain Res., 90, pp. 75-82 
504 |a Guennoun, R., Meffre, D., Labombarda, F., Gonzalez, S.L., Gonzalez Deniselle, M.C., Stein, D.G., De Nicola, A.F., Schumacher, M., The membrane-associated progesterone-binding protein 25-Dx: expression, cellular localization and up-regulation after brain and spinal cord injuries (2008) Brain Res. Rev., 57, pp. 493-505 
504 |a Guerra-Araiza, C., Amorim, M.A., Pinto-Almazán, R., González-Arenas, A., Campos, M.G., Garcia-Segura, L.M., Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain (2009) J. Neurosci. Res., 87, pp. 470-481 
504 |a Guille, C., Spencer, S., Cavus, I., Epperson, C.N., The role of sex steroids in catamenial epilepsy and premenstrual dysphoric disorder: implications for diagnosis and treatment (2008) Epilepsy Behav., 13, pp. 12-24 
504 |a Gulino, R., Lombardo, S.A., Casabona, A., Leanza, G., Perciavalle, V., Levels of brain-derived neurotrophic factor and neurotrophin-4 in lumbar motoneurons after low-thoracic spinal cord hemisection (2004) Brain Res., 1013, pp. 174-181 
504 |a Guo, Q., Sayeed, I., Baronne, L.M., Hoffman, S.W., Guennoun, R., Stein, D.G., Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats (2006) Exp. Neurol., 198, pp. 469-478 
504 |a Hall, E.D., Neuroprotective actions of glucocorticoid and non-glucocorticoid steroids in acute neuronal injury (1993) Cell. Mol. Neurobiol., 13, pp. 415-432 
504 |a Hall, E.D., Pharmacological treatment of acute spinal cord injury: how do we build on past success? (2001) J. Spinal Cord. Med., 24, pp. 142-146 
504 |a Hansson, A.C., Cintra, A., Belluardo, N., Sommer, W., Bhatnagar, M., Bader, M., Ganten, D., Fuxe, K., Gluco- and mineralocorticoid receptor-mediated regulation of neurotrophic factor gene expression in the dorsal hippocampus and neocortex of the rat (2000) Eur. J. Neurosci., 12, pp. 2918-2934 
504 |a He, J., Evans, C.O., Hoffman, S.W., Oyesiku, N.M., Stein, D.G., Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury (2004) Exp. Neurol., 189, pp. 404-412 
504 |a Henderson, J.T., Javaheri, M., Kopko, S., Roder, J.C., Reduction of lower motor neuron degeneration in Wobbler mice by n-acetyl-l-cysteine (1996) J. Neurosci., 16, pp. 7574-7582 
504 |a Hubbard, P., The response of novel NG2 glia to spinal cord injury (2003) Spinal Res., 1, pp. 100-107 
504 |a Hubbard, P., Berry, M., Butt, A., NG2 glia (oligodendrocyte progenitor cells) in the adult rat spinal cord (2002) J. Anat., 200, pp. 213-214 
504 |a Ibanez, C., Shields, S.A., Liere, P., El-Etr, M., Baulieu, E.E., Schumacher, M., Franklin, R.J., Systemic progesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats (2004) Neuropathol. Appl. Neurobiol., 30, pp. 80-89 
504 |a Ikeda, K., Iwasaki, Y., Kinoshita, M., Marubuchi, S., Ono, S., T-588, a novel neuroprotective agent, delays progression of neuromuscular dysfunction in Wobbler mouse motoneuron disease (2000) Brain Res., 858, pp. 84-91 
504 |a Inoue, T., Akahira, J., Suzuki, T., Darnel, D., Kaneko, C., Takahashi, K., Hatori, M.., Sasan, H., Progesterone production and actions in the human central nervous system and neurogenic tumors (2002) J. Clin. Endocrinol. Metab., 87, pp. 5325-5331 
504 |a Irwin, R.W., Yao, J., Hamilton, R.T., Cadenas, E., Brinton, R.D., Nilsen, J., Progesterone and estrogen regulate oxidative metabolism in brain mitochondria (2008) Endocrinology, 149, pp. 3167-3175 
504 |a Ishiyama, T., Ogo, H., Wong, V., Klinkosz, B., Noguchi, H., Nakayama, C., Mitsumoto, H., Methionine-free brain derived neurotrophic factor in Wobbler mouse motor neuron disease: dose-related effects and comparison with the methionyl form (2002) Brain Res., 944, pp. 195-199 
504 |a Ishiyama, T., Okada, R., Nishibe, H., Mitsumoto, H., Nakayama, C., Riluzole slows the progresión of neuromuscular dysfunction in the Wobbler mouse motor neuron disease (2004) Brain Res., 1019, pp. 226-323 
504 |a Jones, K.J., Drengler, S.M., Oblinger, M., Gonadal steroid regulation of growth-associated protein mRNA expression in axotomized hamster facial motor neurons (1997) Neurochem. Res., 22, pp. 1367-1374 
504 |a Jung-Testas, I., Renoir, M., Bugnard, H., Greene, G.L., Baulieu, E.E., Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells (1992) J. Steroid Biochem. Mol. Biol., 41, pp. 621-631 
504 |a Jung-Testas, I., Schumacher, M., Robel, P., Baulieu, E.E., The neurosteroid progesterone increases the expression of myelin proteins (MBP and CNPase) in rat oligodendrocytes in primary culture (1996) Cell. Mol. Neurobiol., 16, pp. 439-443 
504 |a Jung-Testas, I., Schumacher, M., Robel, P., Baulieu, E.E., Demonstration of progesterone receptors in rat Schwann cells (1996) J. Steroid Biochem. Mol. Biol., 58, pp. 77-82 
504 |a Kastrup, Y., Hallbeck, M., Amandusson, A., Hirata, S., Hermanson, O., Blomqvist, A., Progesterone receptor expression in the brainstem of the female rat (1999) Neurosci. Lett., 275, pp. 85-88 
504 |a Kato, J., Onouchi, T., Specific progesterone receptors in the hypothalamus and anterior hypophysis of the rat (1997) Endocrinology, 101, pp. 920-928 
504 |a Kaur, P., Jodhka, P.K., Underwood, W.A., Bowles, C.A., de Fiebre, N.C., de Fiebre, C.M., Singh, M., Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants (2007) J. Neurosci. Res., 85, pp. 2441-2449 
504 |a Kikuchi, H., Doh-ura, K., Kawashima, T., Kira, J., Iwaki, T., Immunohistochemical analysis of spinal cord lesions in amyotrophic lateral sclerosis using microtubule-associated protein 2 (MAP2) antibodies (1999) Acta Neuropathol. (Berl), 97, pp. 13-21 
504 |a Kimbro, K.S., Rosenberg, P.A., Saavedra, R.A., Box I and II motif from myelin basic protein gene promoter binds to nuclear proteins from rodent brain (1994) J. Mol. Neurosci., 5, pp. 27-37 
504 |a Kobayashi, N.R., Fan, D.P., Ghiel, K.M., Bedard, A.M., Wiegand, S.J., Tetzlaff, W., BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha 1-tubulin mRNA expression, and promote axonal regeneration (1997) J. Neurosci., 17, pp. 9583-9595 
504 |a Koda, M., Murakami, M., Ino, H., Yoshinaga, K., Ikeda, O., Hashimoto, M., Yamazaki, N., Moriya, H., Brain-derived neurotrophic factor suppresses delayed apoptosis of oligodendrocytes after spinal cord injury in rats (2002) J. Neurotrauma, 19, pp. 777-785 
504 |a Koenig, H.L., Schumacher, M., Ferzaz, B., Progesterone synthesis and myelin formation by Schwann cells (1995) Science, 268, pp. 1500-1502 
504 |a Labombarda, F., Guennoun, R., Gonzalez, S., Roig, P., Lima, A., Schumacher, M., De Nicola, A.F., Immunocytochemical evidence for a progesterone receptor in neurons and glial cells of the rat spinal cord (2000) Neurosci. Lett., 288, pp. 29-32 
504 |a Labombarda, F., Gonzalez, S.L., Gonzalez Deniselle, M.C., Guennoun, R., Schumacher, M., De Nicola, A.F., Cellular basis for progesterone neuroprotection in the injured spinal cord (2002) J. Neurotrauma, 19, pp. 343-355 
504 |a Labombarda, F., Gonzalez, S.L., Gonzalez Deniselle, M.C., Vinson, G.P., Schumacher, M., De Nicola, A.F., Guennoun, R., Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25-Dx expression in the rat spinal cord (2003) J. Neurochem., 87, pp. 902-913 
504 |a Labombarda, F., Gonzalez, S., Gonzalez Deniselle, M.C., Garay, L., Guennoun, R., Schumacher, M., De Nicola, A.F., Progesterone increases the expression of myelin basic protein and the number of cells showing NG2 immunostaining in the lesioned spinal cord (2006) J. Neurotrauma, 23, pp. 181-192 
504 |a Labombarda, F., Pianos, A., Liere, P., Eychenne, B., Gonzalez, S., Cambourg, A., De Nicola, A.F., Guennoun, R., Injury elicited increase in spinal cord neurosteroid content analyzed by gas chromatography mass spectrometry (2006) Endocrinology, 147, pp. 1847-1859 
504 |a F. Labombarda, D. Meffre, B. Delespierre, S. Krivokapic-Blondiaux., S.L. Gonzalez, A.F. De Nicola, M. Schumacher, R. Guennoun, mPR receptors are expressed in the mouse spinal cord, in: 19th International Symposium of the J. Steroid Biochem. Mol. Biol., Seefeld, Austria 18-21 September 2008 (Abstract); F. Labombarda, S.L. González, A. Lima, P. Roig, R. Guennoun, M. Schumacher, A.F. De Nicola AF. Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury. Glia (2009), in press, doi:10.1002/glia.20814; Leist, M., Jäättelä, M., Four deaths and a funeral: from caspases to alternative mechanisms (2001) Nat. Rev. Mol. Cell. Biol., 2, pp. 589-598 
504 |a Leo, J.C., Lin, V.C., The activities of progesterone receptor isoform A and B are differentially modulated by their ligands in a gene-selective manner (2008) Int. J. Cancer, 122, pp. 230-243 
504 |a Leonelli, E., Bianchi, R., Cavaletti, G., Caruso, D., Crippa, D., Garcia-Segura, L.M., Lauria, G., Melcangi, M.R., Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: a multimodal analysis (2007) Neuroscience, 144, pp. 1293-1304 
504 |a Li, G.L., Farooque, M., Holtz, A., Olsson, Y., Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord (1999) Acta Neuropathol., 98, pp. 473-480 
504 |a Ligon, K.L., Fancy, S.P., Franklin, R.J., Rowitch, D.H., Olig gene function in CNS development and disease (2006) Glia, 54 
504 |a Lim, C.S., Baumann, C.T., Htun, H., Xia, W., Irie, M., Smith, C.L., Hager, G.L., Differential localization and activity of the A- and B-forms of the human progesterone receptor using green fluorescent protein chimeras (1999) Mol. Endocrinol., 13, pp. 366-375 
504 |a Lin, T., Xiang, Z., Cui, L., Stallcup, W., Reeves, S.A., New mouse oligodendrocyte precursor (mOP) cells for studies on oligodendrocyte maturation and function (2006) J. Neurosci. Methods, 157, pp. 187-194 
504 |a MacLusky, N.J., McEwen, B.S., Progestin receptors in rat brain: distribution and properties of cytoplasmic progestin-binding sites (1980) Endocrinology, 106, pp. 192-202 
504 |a Majewska, M.D., Harrison, N.L., Shwartz, R.D., Barker, J.L., Paul, S.M., Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor (1986) Science, 232, pp. 1004-1007 
504 |a Mani, S., Progestin receptor subtypes in the brain: the known and the unknown (2008) Endocrinology, 149, pp. 2750-2756 
504 |a Marsh, H.N., Scholz, W.K., Lamballe, F., Klein, R., Nanduri, V., Barbacid, M., Palfrey, H.C., Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture (1993) J. Neurosci., 13, pp. 4281-4292 
504 |a Matsumoto, T., Rauskolb, S., Polack, M., Klose, J., Kolbeck, R., Korte, M., Barde, Y.A., Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF (2008) Nat. Neurosci., 11, pp. 131-133 
504 |a McIlwain, D.L., Hoke, V.B., The role of the cytoskeleton in cell body enlargement, increased nuclear eccentricity and chromatolysis in axotomized spinal motor neurons (2005) BMC Neurosci., 6, pp. 1-13 
504 |a McTigue, D.M., Tripathi, R.B., The life, death, and replacement of oligodendrocytes in the adult CNS (2008) J. Neurochem., 107 
504 |a Meffre, D., Delespierre, B., Gouezou, M., Leclerc, P., Vinson, G.P., Schumacher, M., Stein, D.G., Guennoun, R., The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury (2005) J. Neurochem., 93, pp. 1314-1326 
504 |a Meffre, D., Pianos, A., Liere, P., Eychenne, B., Cambourg, A., Schumacher, M., Stein, D.G., Guennoun, R., Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry (2007) Endocrinology, 148, pp. 2505-2517 
504 |a Melcangi, R.C., Magnaghi, V., Martini, L., Aging in peripheral nerves: regulation of myelin protein genes by steroid hormones (2000) Prog. Neurobiol., 60, pp. 291-308 
504 |a Migliaccio, A., Piccolo, D., Castoria, G., Di Domenico, M., Bilancio, A., Lombardi, M., Gong, W., Auricchio, F., Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor (1998) EMBO J., 17, pp. 2008-2018 
504 |a Mitsumoto, H., Bradley, W.G., Murine motor neuron disease (the Wobbler mouse): degeneration and regeneration of the lower motor neuron (1982) Brain Res., 105, pp. 811-834 
504 |a Mitsumoto, H., Ikeda, K., Klinkosz, B., Cedarbaum, J.M., Wong, V., Lindsay, R.M., Arrest of motor neuron disease in Wobbler mice cotreated with CNTF and BDNF (1994) Science, 265, pp. 1052-1053 
504 |a Monteleone, P., Luisi, S., Tonetti, A., Bernardi, F., Genazzani, A.D., Luisi, M., Petraglia, F., Genazzani, A.R., Allopregnanolone concentrations and premenstrual syndrome (2000) Eur. J. Endocrinol., 142, pp. 269-273 
504 |a Nacimiento, W., Sappok, T., Brook, G.A., Tóth, L., Schoen, S.W., Noth, J., Kreutzberg, G.W., Structural changes of anterior horn neurons and their synaptic input caudal to low thoracic spinal cord hemisection in the adult rat: a light and electron microscopic study (1995) Acta Neuropathol., 90, pp. 552-564 
504 |a Nagappan, G., Lu, B., Activity-dependent modulation of BDNF receptor TrkB: mechanisms and implications (2005) Trends Neurosci., 28, pp. 464-471 
504 |a Nakamura, M., Bregman, B.S., Differences in neurotrophic factor gene expression profiles between neonate and adult spinal cord after injury (2001) Exp. Neurol., 169, pp. 407-415 
504 |a Nicolay, D.J., Doucette, J.R., Nazarali, A.J., Transcriptional control of oligodendrogenesis (2007) Glia, 55, pp. 1287-1299 
504 |a Nishiyama, A., Chang, A., Trapp, B.D., NG2+ glial cells: a novel glial cell population in the adult brain (1999) J. Neuropathol. Exp. Neurol., 58, pp. 1113-1124 
504 |a Nordeen, S.K., Kühnel, B., Lawler-Heavner, J., Barber, D.A., Edwards, D.P., A quantitative comparison of dual control of a hormone response element by progestins and glucocorticoids in the same cell line (1989) Mol. Endocrinol., 3, pp. 1270-1278 
504 |a O'Connor, C.A., Cernak, I., Vink, R., Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats (2005) Brain Res., 1062, pp. 171-174 
504 |a O'Connor, C.A., Cernak, I., Johnson, F., Vink, R., Effects of progesterone on neurologic and morphologic outcome following diffuse traumatic brain injury in rats (2007) Exp. Neurol., 205, pp. 145-153 
504 |a Oda, Y., Imai, S., Nakanishi, I., Ichikawa, T., Deguchi, T., Immunohistochemical study on choline acetyltransferase in the spinal cord of patients with amyotrophic lateral sclerosis (1995) Pathol. Int., 45, pp. 933-939 
504 |a Ogata, T., Nakamura, Y., Tsuji, K., Shibata, T., Kataoka, K., Steroid hormones protect spinal cord neurons from glutamate toxicity (1993) Neuroscience, 55, pp. 445-449 
504 |a Pan, D.S., Liu, W.G., Yang, X.F., Cao, F., Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury (2007) Biomed. Environ. Sci., 20, pp. 432-438 
504 |a Pettus, E.H., Wright, D.W., Stein, D.G., Hoffman, S.W., Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury (2005) Brain Res., 1049, pp. 112-119 
504 |a Price, D.L., Porter, K.R., The response of ventral horn neurons to axonal transection (1972) J. Cell Biol., 53, pp. 24-37 
504 |a Priestley, J.V.M.S., Ramer, M.S., King, V.R., McMahon, S.B., Brown, R.A., Stimulating regeneration in the damaged spinal cord (2000) J. Physiol. (Paris), 96, pp. 123-133 
504 |a Qi, Y., Cai, J., Wu, Y., Wu, R., Lee, J., Fu, H., Rao, M., Qiu, M., Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor (2001) Development, 128, pp. 2723-2733 
504 |a Reyna-Neyra, A., Camacho-Arroyo, I., Ferrera, P., Arias, C., Estradiol and progesterone modify microtubule associated protein 2 content in the rat hippocampus (2002) Brain Res. Bull., 58, pp. 607-612 
504 |a Ritsner, M.S., Weizman, A., (2008) Neuroactive Steroids in Brain Function: Behaviour and Neuropsychiatric Disorders, , Springer 
504 |a Robertson, C.L., Puskar, A., Hoffman, G.E., Murphy, A.Z., Saraswati, M., Fiskum, G., Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats (2006) Exp. Neurol., 197, pp. 235-243 
504 |a Roglio, I., Bianchi, R., Gotti, S., Giatti, S., Pesaresi, M., Caruso, D., Panzica, G.C., Melcangi, R.C., Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury (2008) Neuroscience, 155, pp. 673-685 
504 |a Rosenberg, L.J., Zai, L.J., Wrathall, J.R., Chronic alterations in the cellular composition of spinal cord white matter following contusion injury (2005) Glia, 49, pp. 107-120 
504 |a Roof, R.L., Duvdevani, R., Stein, D.G., Gender influences outcome of brain injury: progesterone plays a protective role (1993) Brain Res., 607, pp. 333-336 
504 |a Roof, R.L., Duvdevani, R., Braswell, L., Stein, D.G., Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats (1994) Exp. Neurol., 129, pp. 64-69 
504 |a Roof, R.L., Duvdevani, R., Heyburn, J.W., Stein, D.G., Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective (1996) Exp. Neurol., 138, pp. 246-251 
504 |a Roof, R.L., Hoffman, S.W., Stein, D.G., Progesterone protects against lipid peroxidation following traumatic brain injury in rats (1997) Mol. Chem. Neuropathol., 31, pp. 1-11 
504 |a Santoro, B., Bigini, P., Levandis, G., Nobile, V., Biggiogera, M., Botti, F., Mennini, T., Curti, D., Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease (2004) Neurobiol. Dis., 17, pp. 349-357 
504 |a Schumacher, M., Guennoun, R., Stein, D.G., De Nicola, A.F., Progesterone: therapeutic opportunities for neuroprotection and myelin repair (2007) Pharmacol. Ther., 116, pp. 77-106 
504 |a Schumacher, M., Sitruk-Ware, R., De Nicola, A.F., Progesterone and progestins: neuroprotection and myelin repair (2008) Curr. Opin. Pharmacol., 8, pp. 40-746 
504 |a Selye, H., Textbook of Endocrinology (1947) Acta Endocrinologica, , Université de Montreal, Canada 
504 |a Siegenthaler, M.M., Tu, M.K., Keirstead, H.S., The extent of myelin pathology differs following contusion and transection spinal cord injury (2007) J. Neurotrauma, 24, pp. 1631-1646 
504 |a Shear, D.A., Galani, R., Hoffman, S.W., Stein, D.G., Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury (2002) Exp. Neurol., 178, pp. 59-67 
504 |a Sohrabji, F., Miranda, R.C., Toran-Allerand, C.D., Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 11110-11114 
504 |a Song, L.N., Huse, B., Rusconi, S., Simons, S.S., Transactivation specificity of glucocorticoid versus progesterone receptors. Role of functionally different interactions of transcription factors with amino- and carboxyl-terminal receptor domains (2001) J. Biol. Chem., 276, pp. 24806-24816 
504 |a Sperandio, S., de Belle, I., Bredesen, D.E., An alternative, nonapoptotic form of programmed cell death (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 14376-14381 
504 |a Springer, J.E., Azbill, R.D., Kennedy, S.E., George, J., Geddes, J.W., Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment (1997) J. Neurochem., 69, pp. 1592-1600 
504 |a Stein, D.G., Brain damage, sex hormones and recovery: a new role for progesterone and estrogen? (2001) Trends Neurosci., 24, pp. 386-391 
504 |a Stein, D.G., Wright, D.W., Kellermann, A.L., Does progesterone have neuroprotective properties? (2008) Ann. Emerg. Med., 51, pp. 164-172 
504 |a Stein, D.G., Progesterone exerts neuroprotective effects after brain injury (2008) Brain Res. Rev., 57, pp. 386-397 
504 |a Tator, C.H., Update on the pathophysiology and pathology of acute spinal cord injury (1995) Brain Pathol., 5, pp. 407-413 
504 |a Thoenen, H., Neurotrophins and neuronal plasticity (1995) Science, 270, pp. 593-598 
504 |a Thomas, A., Nockels, R., Pan, H., Progesterone is neuroprotective after acute experimental spinal cord trauma in rats (1999) Spine, 24, pp. 2134-2138 
504 |a Tsuzaka, K., Ishiyama, T., Pioro, E.P., Mitsumoto, H., Role of brain-derived neurotrophic factor in Wobbler mouse motor neuron disease (2001) Muscle Nerve, 24, pp. 474-480 
504 |a Vandromme, M., Melton, S.M., Kerby, J.D., Progesterone in traumatic brain injury: time to move on to phase III trials (2008) Crit. Care, 12, p. 153 
504 |a VanLandingham, J.M., Cutler, S.M., Virmani, S., Hoffman, S.W., Covey, D.F., Krishnan, K., Hammes, S.R., Stein, D.G., The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury (2006) Neuropharmacology, 51, pp. 1078-1085 
504 |a VanLandingham, J.W., Cekic, M., Cutler, S.M., Hoffman, S.W., Washington, E.R., Johnson, S.J., Miller, D., Stein, D.G., Progesterone and its metabolite allopregnanolone differentially regulate hemostatic proteins after traumatic brain injury (2008) J. Cereb. Blood Flow Metab., 28, pp. 1786-1794 
504 |a Vedekis, W., Nuclear receptors, transcriptional regulation, and oncogenesis (1992) Proc. Soc. Exp. Biol. Med., 199, pp. 1-12 
504 |a Wagner, A.K., Willard, L.A., Kline, A.E., Wenger, M.K., Bolinger, B.D., Ren, D., Zafonte, R.D., Dixon, C.E., Evaluation of estrous cycle stage and gender on behavioral outcome after experimental traumatic brain injury (2004) Brain Res., 998, pp. 113-121 
504 |a Watanabe, M., Hadzic, T., Nishiyama, A., Transient upregulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination (2004) Glia, 46, pp. 311-322 
504 |a Waters, E.M., Torres-Reveron, A., McEwen, B.S., Milner, T.A., Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formation (2008) J. Comp. Neurol., 511, pp. 34-46 
504 |a Wright, D.W., Hoffman, S.W., Virmani, S., Stein, D.G., Effects of medroxyprogesterone acetate on cerebral oedema and spatial learning performance after traumatic brain injury in rats (2006) Brain Inj., 22, pp. 107-113 
504 |a Wright, D.W., Kellermann, A.L., Hertzberg, V.S., Clark, P.L., Frankel, M., Goldstein, F.C., Salomone, J.P., Stein, D.G., ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury (2007) Ann. Emerg. Med., 49, pp. 391-402 
504 |a Xiao, G.M., Wei, J., Wu, Z.H., Wang, W.M., Jiang, Q.Z., Cheng, J., Lu, F., Fang, R., Clinical study on the therapeutic effects and mechanism of progesterone in the treatment for acute severe head injury (2007) Zhonghua Wai Ke Za Zhi, 4, pp. 106-108 
504 |a Xu, G.P., Dave, K.R., Moraes, C.T., Busto, R., Sick, T.J., Bradley, W.G., Pérez-Pinzón, M.A., Dysfunctional mitochondrial respiration in the Wobbler mouse brain (2001) Neurosci. Lett., 300, pp. 141-144 
504 |a Yan, Q.C., Matheson, C., Lopez, O., The biological responses of axotomized adult motoneurones to brain-derived neurotrophic factor (1994) J. Neurosci., 14, pp. 5281-5291 
504 |a Yao, X.L., Liu, J., Lee, E., Ling, G.S., McCabe, J.T., Progesterone differentially regulates pro- and anti-apoptotic gene expression in cerebral cortex following traumatic brain injury in rats (2005) J. Neurotrauma, 22, pp. 656-668 
504 |a Yu, W.H., Survival of motoneurones following axotomy is enhanced by lactation or by progesterone treatment (1989) Brain Res., 49, pp. 379-382 
504 |a Yung, K.K.L., Tang, F., Vacca-Galloway, L.L., Changes of neuropeptides in spinal cord and brain stem of Wobbler mouse at different stages of motoneuron disease (1992) Neuroscience, 50, pp. 209-222 
504 |a Zai, L.J., Wrathall, J.R., Cell proliferation and replacement following contusive spinal cord injury (2005) Glia, 50, pp. 247-257 
504 |a Zhang, J.Y., Luo, X.G., Xian, C.J., Liu, Z.H., Zhou, X.F., Endogenous BDNF is required for myelination and regeneration of injured sciatic nerve in rodents (2000) Eur. J. Neurosci., 12, pp. 4171-4180 
504 |a Zhu, W., Wiggins, R.C., Konat, G.W., Glucocorticoid-induced upregulation of proteolipid protein and myelin-associated glycoprotein genes in C6 cells (1994) J. Neurosci. Res., 37, pp. 208-212 
504 |a Zhu, Y., Hanna, R.N., Schaaf, M.J., Spaink, H.P., Thomas, P., Candidates for membrane progestin receptors-past approaches and future challenges (2008) Comp. Biochem. Physiol. C. Toxicol. Pharmacol., 148, pp. 381-389 
504 |a Zilliacus, J., Wright, A., Carlstedt-Duke, J., Gustafsson, J.-A., Structural determinants of DNA-binding specificity by steroid receptor (1995) Mol. Endocrinol., 4, pp. 389-400 
520 3 |a Studies on the neuroprotective and promyelinating effects of progesterone in the nervous system are of great interest due to their potential clinical connotations. In peripheral neuropathies, progesterone and reduced derivatives promote remyelination, axonal regeneration and the recovery of function. In traumatic brain injury (TBI), progesterone has the ability to reduce edema and inflammatory cytokines, prevent neuronal loss and improve functional outcomes. Clinical trials have shown that short-and long-term progesterone treatment induces a significant improvement in the level of disability among patients with brain injury. In experimental spinal cord injury (SCI), molecular markers of functional motoneurons become impaired, including brain-derived neurotrophic factor (BDNF) mRNA, Na,K-ATPase mRNA, microtubule-associated protein 2 and choline acetyltransferase (ChAT). SCI also produces motoneuron chromatolysis. Progesterone treatment restores the expression of these molecules while chromatolysis subsided. SCI also causes oligodendrocyte loss and demyelination. In this case, a short progesterone treatment enhances proliferation and differentiation of oligodendrocyte progenitors into mature myelin-producing cells, whereas prolonged treatment increases a transcription factor (Olig1) needed to repair injury-induced demyelination. Progesterone neuroprotection has also been shown in motoneuron neurodegeneration. In Wobbler mice spinal cord, progesterone reverses the impaired expression of BDNF, ChAT and Na,K-ATPase, prevents vacuolar motoneuron degeneration and the development of mitochondrial abnormalities, while functionally increases muscle strength and the survival of Wobbler mice. Multiple mechanisms contribute to these progesterone effects, and the role played by classical nuclear receptors, extra nuclear receptors, membrane receptors, and the reduced metabolites of progesterone in neuroprotection and myelin formation remain an exciting field worth of exploration. © 2009 Elsevier Inc. All rights reserved.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires, MO16 
536 |a Detalles de la financiación: Institut National de la Santé et de la Recherche Médicale 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 112-200801-00542, PIP 5542 
536 |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica, PICT 2007 # 01044, PICT 2004 # 5-25610 
536 |a Detalles de la financiación: Preparation of this review was supported by grants from CONICET (PIP 5542 and PIP 112-200801-00542), the University of Buenos Aires (MO16), FONCYT (PICT 2004 # 5-25610 and PICT 2007 # 01044) and a Cooperative Program between CONICET and INSERM. The authors deeply acknowledge the technical assistance of Mrs. Ana Lima and Ms. Paulina Roig and the art design of Mrs. Inés Labombarda. 
593 |a Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Obligado 2490, 1428 Buenos Aires, Argentina 
593 |a Dept. of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina 
593 |a UMR788 Inserm and University Paris-Sud 11, Kremlin-Bicêtre, France 
690 1 0 |a BRAIN INJURY 
690 1 0 |a MYELINATION 
690 1 0 |a NEUROACTIVE STEROID 
690 1 0 |a NEURODEGENERATION 
690 1 0 |a OLIGODENDROCYTES 
690 1 0 |a PROGESTERONE 
690 1 0 |a SPINAL CORD 
690 1 0 |a WOBBLER MOUSE 
690 1 0 |a 20ALPHA DIHYDROPROGESTERONE 
690 1 0 |a 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE 
690 1 0 |a ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) 
690 1 0 |a BRAIN DERIVED NEUROTROPHIC FACTOR 
690 1 0 |a CELL NUCLEUS RECEPTOR 
690 1 0 |a CHOLINE ACETYLTRANSFERASE 
690 1 0 |a MEDROXYPROGESTERONE ACETATE 
690 1 0 |a MEMBRANE RECEPTOR 
690 1 0 |a MESSENGER RNA 
690 1 0 |a MICROTUBULE ASSOCIATED PROTEIN 2 
690 1 0 |a MYELIN 
690 1 0 |a PLACEBO 
690 1 0 |a PROGESTERONE 
690 1 0 |a PROGESTERONE RECEPTOR 
690 1 0 |a BRAIN EDEMA 
690 1 0 |a BRAIN INJURY 
690 1 0 |a CELL LOSS 
690 1 0 |a CENTRAL NERVOUS SYSTEM DISEASE 
690 1 0 |a CLINICAL TRIAL 
690 1 0 |a DEMYELINATION 
690 1 0 |a DIABETIC NEUROPATHY 
690 1 0 |a DISABILITY 
690 1 0 |a DISORDERS OF MITOCHONDRIAL FUNCTIONS 
690 1 0 |a DOSE RESPONSE 
690 1 0 |a DRUG EFFICACY 
690 1 0 |a DRUG MECHANISM 
690 1 0 |a DRUG MEGADOSE 
690 1 0 |a DRUG SAFETY 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a HORMONE ACTION 
690 1 0 |a HUMAN 
690 1 0 |a IMMUNOHISTOCHEMISTRY 
690 1 0 |a LOW DRUG DOSE 
690 1 0 |a MOTONEURON 
690 1 0 |a MOUSE STRAIN 
690 1 0 |a MUSCLE STRENGTH 
690 1 0 |a NERVE DEGENERATION 
690 1 0 |a NERVE FIBER REGENERATION 
690 1 0 |a NERVE FUNCTION 
690 1 0 |a NERVE INJURY 
690 1 0 |a NERVOUS SYSTEM INJURY 
690 1 0 |a NEUROANATOMY 
690 1 0 |a NEUROCHEMISTRY 
690 1 0 |a NEUROPROTECTION 
690 1 0 |a NONHUMAN 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a OPTIMAL DRUG DOSE 
690 1 0 |a PERIPHERAL NERVE INJURY 
690 1 0 |a PERIPHERAL NEUROPATHY 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a REMYELINIZATION 
690 1 0 |a REVIEW 
690 1 0 |a SEX DIFFERENCE 
690 1 0 |a SPINAL CORD INJURY 
690 1 0 |a TRAUMATIC BRAIN INJURY 
690 1 0 |a TREATMENT DURATION 
690 1 0 |a ANIMALS 
690 1 0 |a BRAIN INJURIES 
690 1 0 |a BRAIN-DERIVED NEUROTROPHIC FACTOR 
690 1 0 |a CLINICAL TRIALS AS TOPIC 
690 1 0 |a DISEASE MODELS, ANIMAL 
690 1 0 |a HUMANS 
690 1 0 |a MICE 
690 1 0 |a MICE, NEUROLOGIC MUTANTS 
690 1 0 |a MOTOR NEURONS 
690 1 0 |a MYELIN SHEATH 
690 1 0 |a NERVE DEGENERATION 
690 1 0 |a NEUROPROTECTIVE AGENTS 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a RECEPTORS, PROGESTERONE 
690 1 0 |a SEX FACTORS 
690 1 0 |a SPINAL CORD INJURIES 
690 1 0 |a TRAUMA, NERVOUS SYSTEM 
700 1 |a Labombarda, F. 
700 1 |a Deniselle, M.C.G. 
700 1 |a Gonzalez, S.L. 
700 1 |a Garay, L. 
700 1 |a Meyer, M. 
700 1 |a Gargiulo, G. 
700 1 |a Guennoun, R. 
700 1 |a Schumacher, M. 
773 0 |d 2009  |g v. 30  |h pp. 173-187  |k n. 2  |p Front. Neuroendocrinol.  |x 00913022  |t Frontiers in Neuroendocrinology 
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856 4 0 |u https://doi.org/10.1016/j.yfrne.2009.03.001  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00913022_v30_n2_p173_DeNicola  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913022_v30_n2_p173_DeNicola  |y Registro en la Biblioteca Digital 
961 |a paper_00913022_v30_n2_p173_DeNicola  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 84097 

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