Effects of Progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury

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Progesterone is emerging as a myelinizing factor for central nervous system injury. Successful remyelination requires proliferation and differentiation of oligodendrocyte precursor cells (OPC) into myelinating oligodendrocytes, but this process is incomplete following injury. To study progesterone a...

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Autor principal: Labombarda, F.
Otros Autores: González, S.L, Lima, A., Roig, P., Guennoun, R., Schumacher, M., De Nicola, A.F
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2009
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proluton, Schering, Argentina
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 Molecular Sequence Numbers  |a GENBANK: AF151367, BC094522, EF156276, NM_022668, NM_030990, XM_345446; 
024 7 |2 cas  |a broxuridine, 59-14-3; progesterone, 57-83-0; Basic Helix-Loop-Helix Transcription Factors; Homeodomain Proteins; Myelin Proteins; Myelin Proteolipid Protein; Myelin-Associated Glycoprotein; Nerve Tissue Proteins; Nkx-2.2 homedomain protein; Olig1 protein, rat; Plp1 protein, rat; Progesterone, 57-83-0; Progestins; RNA, Messenger; Transcription Factors; oligodendrocyte-myelin glycoprotein 
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030 |a GLIAE 
100 1 |a Labombarda, F. 
245 1 0 |a Effects of Progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury 
260 |c 2009 
270 1 0 |m de Nicola, A.F.; Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina; email: denicola@dna.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Progesterone is emerging as a myelinizing factor for central nervous system injury. Successful remyelination requires proliferation and differentiation of oligodendrocyte precursor cells (OPC) into myelinating oligodendrocytes, but this process is incomplete following injury. To study progesterone actions on remyelination, we administered progesterone (16 mg/kg/day) to rats with complete spinal cord injury. Rats were euthanized 3 or 21 days after steroid treatment. Short progesterone treatment (a) increased the number of OPC without effect on the injury-induced reduction of mature oligodendrocytes, (b) increased mRNA and protein expression for the myelin basic protein (MBP) without effects on proteolipid protein (PLP) or myelin oligodendrocyte glycoprotein (MOG), and (c) increased the mRNA for Olig2 and Nkx2.2 transcription factors involved in specification and differentiation of the oligodendrocyte lineage. Furthermore, long progesterone treatment (a) reduced OPC with a concomitant increase of oligodendrocytes; (b) promoted differentiation of cells that incorporated bromodeoxyuridine, early after injury, into mature oligodendrocytes; (c) increased mRNA and protein expression of PLP without effects on MBP or MOG; and (d) increased mRNA for the Olig1 transcription factor involved in myelin repair. These results suggest that early progesterone treatment enhanced the density of OPC and induced their differentiation into mature oligodendrocytes by increasing the expression of Olig2 and Nkx2.2. Twenty-one days after injury, progesterone favors remyelination by increasing Olig1 (involved in repair of demyelinated lesions), PLP expression, and enhancing oligodendrocytes maturation. Thus, progesterone effects on oligodendrogenesis and myelin proteins may constitute fundamental steps for repairing traumatic injury inflicted to the spinal cord. © 2008 Wiley-Liss, Inc.  |l eng 
593 |a Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, CONICET, Obligado 2490, 1428 Buenos Aires, Argentina 
593 |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina 
593 |a UMR788 Inserm, University Paris-Sud 11, Kremlin-Bicêtre, France 
690 1 0 |a NG2 CELLS 
690 1 0 |a NKX2.2 
690 1 0 |a OLIG1 
690 1 0 |a OLIG2 
690 1 0 |a REMYELINATION 
690 1 0 |a STEROIDS 
690 1 0 |a TRAUMA 
690 1 0 |a BROXURIDINE 
690 1 0 |a MESSENGER RNA 
690 1 0 |a MYELIN BASIC PROTEIN 
690 1 0 |a MYELIN OLIGODENDROCYTE GLYCOPROTEIN 
690 1 0 |a MYELIN PROTEIN 
690 1 0 |a NUCLEIC ACID BINDING PROTEIN 
690 1 0 |a OLIGODENDROCYTE TRANSCRIPTION FACTOR 1 
690 1 0 |a OLIGODENDROCYTE TRANSCRIPTION FACTOR 2 
690 1 0 |a PROGESTERONE 
690 1 0 |a PROTEOLIPID PROTEIN 
690 1 0 |a TRANSCRIPTION FACTOR 
690 1 0 |a TRANSCRIPTION FACTOR NKX2.2 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR 
690 1 0 |a GESTAGEN 
690 1 0 |a HOMEODOMAIN PROTEIN 
690 1 0 |a MESSENGER RNA 
690 1 0 |a MYELIN ASSOCIATED GLYCOPROTEIN 
690 1 0 |a MYELIN PROTEIN 
690 1 0 |a NERVE PROTEIN 
690 1 0 |a NKX 2.2 HOMEDOMAIN PROTEIN 
690 1 0 |a NKX-2.2 HOMEDOMAIN PROTEIN 
690 1 0 |a OLIG1 PROTEIN, RAT 
690 1 0 |a OLIGODENDROCYTE MYELIN GLYCOPROTEIN 
690 1 0 |a OLIGODENDROCYTE-MYELIN GLYCOPROTEIN 
690 1 0 |a PLP1 PROTEIN, RAT 
690 1 0 |a PROGESTERONE 
690 1 0 |a PROTEOLIPID PROTEIN 
690 1 0 |a TRANSCRIPTION FACTOR 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL MODEL 
690 1 0 |a ARTICLE 
690 1 0 |a CELL COUNT 
690 1 0 |a CELL DENSITY 
690 1 0 |a CELL FUNCTION 
690 1 0 |a CELL LINEAGE 
690 1 0 |a CELL PROLIFERATION 
690 1 0 |a CELL SPECIFICITY 
690 1 0 |a CHRONIC DRUG ADMINISTRATION 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DEMYELINATION 
690 1 0 |a DOWN REGULATION 
690 1 0 |a DRUG MECHANISM 
690 1 0 |a EARLY INTERVENTION 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a HORMONE ACTION 
690 1 0 |a MALE 
690 1 0 |a NERVE CELL DIFFERENTIATION 
690 1 0 |a NEURAL STEM CELL 
690 1 0 |a NONHUMAN 
690 1 0 |a NUCLEOTIDE SEQUENCE 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN EXPRESSION 
690 1 0 |a PROTEIN FUNCTION 
690 1 0 |a RAT 
690 1 0 |a REMYELINIZATION 
690 1 0 |a SHORT COURSE THERAPY 
690 1 0 |a SPINAL CORD INJURY 
690 1 0 |a UPREGULATION 
690 1 0 |a ADULT STEM CELL 
690 1 0 |a ANIMAL 
690 1 0 |a DISEASE MODEL 
690 1 0 |a DRUG EFFECT 
690 1 0 |a GENETICS 
690 1 0 |a METABOLISM 
690 1 0 |a METHODOLOGY 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a ORCHIECTOMY 
690 1 0 |a SPRAGUE DAWLEY RAT 
690 1 0 |a TIME 
690 1 0 |a ADULT STEM CELLS 
690 1 0 |a ANIMALS 
690 1 0 |a BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS 
690 1 0 |a DISEASE MODELS, ANIMAL 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a HOMEODOMAIN PROTEINS 
690 1 0 |a MALE 
690 1 0 |a MYELIN PROTEINS 
690 1 0 |a MYELIN PROTEOLIPID PROTEIN 
690 1 0 |a MYELIN-ASSOCIATED GLYCOPROTEIN 
690 1 0 |a NERVE TISSUE PROTEINS 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a ORCHIECTOMY 
690 1 0 |a PROGESTERONE 
690 1 0 |a PROGESTINS 
690 1 0 |a RATS 
690 1 0 |a RATS, SPRAGUE-DAWLEY 
690 1 0 |a RNA, MESSENGER 
690 1 0 |a SPINAL CORD INJURIES 
690 1 0 |a TIME FACTORS 
690 1 0 |a TRANSCRIPTION FACTORS 
653 0 0 |a proluton, Schering, Argentina 
700 1 |a González, S.L. 
700 1 |a Lima, A. 
700 1 |a Roig, P. 
700 1 |a Guennoun, R. 
700 1 |a Schumacher, M. 
700 1 |a De Nicola, A.F. 
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