Inhibition of Junín virus replication by small interfering RNAs
Junín virus (JUNV), the etiological agent of the Argentine hemorrhagic fever, has a single-stranded RNA genome with ambisense expression which encodes for five proteins. In previous works we have demonstrated that the Z arenavirus matrix protein represents an attractive target for antiviral therapy....
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2009
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 13643caa a22014057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-23076 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205443.0 | ||
| 008 | 190411s2009 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-69249213996 | |
| 024 | 7 | |2 Molecular Sequence Numbers |a GENBANK: AF004519, AY619640, AY819707, DQ538136, NC_004292, NC_005080; | |
| 024 | 7 | |2 cas |a RNA, Small Interfering | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ARSRD | ||
| 100 | 1 | |a Artuso, M.C. | |
| 245 | 1 | 0 | |a Inhibition of Junín virus replication by small interfering RNAs |
| 260 | |c 2009 | ||
| 270 | 1 | 0 | |m García, C.C.; Laboratory of Virology, Department of Biological Chemistry, School of Sciences, Ciudad Universitaria, Pabellon 2, Piso 4, 1428 Buenos Aires, Argentina; email: cygarcia@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Neuman, B.W., Adair, B.D., Burns, J.W., Milligan, R.A., Buchmeier, M.J., Yeager, M., Complementary in the supramolecular design of arenavirus and retroviruses revealed by electron cryomicroscopy and image analysis (2005) J. Virol., 79, pp. 3822-3830 | ||
| 504 | |a Perez, M., Craven, R.C., de la Torre, J.C., The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 12978-12983 | ||
| 504 | |a Perez, M., Greenwald, D.L., de la Torre, J.C., Myristoylation of the RING finger Z protein is essential for arenavirus budding (2004) J. Virol., 78, pp. 11443-11448 | ||
| 504 | |a Salvato, M.S., Molecular biology of the prototype arenavirus, lymphocytic choriomeningitis virus (1993) The Arenaviridae, pp. 133-156. , Salvato M.S. (Ed), Plenum Press, New York | ||
| 504 | |a Salvato, M.S., Schweighofer, K.J., Burns, J., Shimomaye, E.M., Biochemical and immunological evidence that the 11 kDa zinc-binding protein of lymphocytic choriomeningitis virus is a structural component of the virus (1992) Virus Res., 22, pp. 185-198 | ||
| 504 | |a Sánchez, A.B., Perez, M., Cornu, T., de la Torre, J.C., RNA interference-mediated virus clearance from cells both acutely and chronically infected with the prototypic arenavirus lymphocytic choriomeningitis virus (2005) J. Virol., 79, pp. 11071-11081 | ||
| 504 | |a Sánchez, A., Pifat, D.Y., Kenyon, R.H., Peters, C.J., McCormick, J.B., Kiley, M.P., Junin virus monoclonal antibodies: characterization and cross-reactivity with other arenaviruses (1989) J. Gen. Virol., 70, pp. 1125-1132 | ||
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| 504 | |a Zhang, Y., Li, T., Fu, L., Yu, C., Li, Y., Xu, X., Wang, Y., Chang, Z., Silencing SARS-CoV spike protein expression in cultured cells by RNA interference (2004) FEBS Lett., 27, pp. 141-146 | ||
| 520 | 3 | |a Junín virus (JUNV), the etiological agent of the Argentine hemorrhagic fever, has a single-stranded RNA genome with ambisense expression which encodes for five proteins. In previous works we have demonstrated that the Z arenavirus matrix protein represents an attractive target for antiviral therapy. With the aim of studying a new alternative therapeutic mechanism, four Z-specific siRNAs (Z1- to Z4-siRNAs) were tested showing variable efficacy. The most effective inhibitor was Z2-siRNA targeted at the region encompassed by nt 179-197 of Z gene. The efficacy of this Z2-siRNA against JUNV was also demonstrated in virus-infected cells, by testing infectious virus plaque formation (92.8% JUNV yield reduction), viral RNA level or antigen expression, as well as in cells transfected with Z-specific reporter plasmids (91% reduction in expression of Z-EGFP fusion protein). Furthermore, the lack of effect of this Z-siRNA on the expression of other JUNV proteins, such as N and GPC, confirmed the specificity of action exerted by Z2-siRNA on Z transcript. Thus, the present study represents the first report of virus inhibition mediated by RNA interference for a New World arenavirus. © 2009 Elsevier B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Fundación Bunge y Born | ||
| 536 | |a Detalles de la financiación: This work was supported by funding to the group from the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Agencia Nacional de Promoción Científica y Tecnológica, Universidad de Buenos Aires, and Fundación Bunge and Born, Argentina. CCG, LAS and EBD are members of the Research Career from CONICET. We are thankful to Dr A. Sanchez and Dr T. Ksiazek (CDC, Atlanta, GA) for providing JUNV mAbs. | ||
| 593 | |a Laboratory of Virology, Department of Biological Chemistry, School of Sciences, Ciudad Universitaria, Pabellon 2, Piso 4, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ARENAVIRUS |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 690 | 1 | 0 | |a MATRIX PROTEIN |
| 690 | 1 | 0 | |a RNA INTERFERENCE |
| 690 | 1 | 0 | |a SIRNAS |
| 690 | 1 | 0 | |a GUANINE NUCLEOTIDE BINDING PROTEIN |
| 690 | 1 | 0 | |a SMALL INTERFERING RNA |
| 690 | 1 | 0 | |a VIRUS ANTIGEN |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANTIGEN EXPRESSION |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DRUG EFFICACY |
| 690 | 1 | 0 | |a DRUG SPECIFICITY |
| 690 | 1 | 0 | |a DRUG TARGETING |
| 690 | 1 | 0 | |a GENETIC TRANSFECTION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NUCLEOTIDE SEQUENCE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a RNA INTERFERENCE |
| 690 | 1 | 0 | |a VIRUS INHIBITION |
| 690 | 1 | 0 | |a VIRUS PLAQUE |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ARENAVIRIDAE INFECTIONS |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a CRICETINAE |
| 690 | 1 | 0 | |a DOWN-REGULATION |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a RNA INTERFERENCE |
| 690 | 1 | 0 | |a RNA, SMALL INTERFERING |
| 690 | 1 | 0 | |a SEQUENCE ALIGNMENT |
| 690 | 1 | 0 | |a VERO CELLS |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a ARENAVIRUS |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 650 | 1 | 7 | |2 spines |a VIRUS RNA |
| 700 | 1 | |a Ellenberg, P.C. | |
| 700 | 1 | |a Scolaro, L.A. | |
| 700 | 1 | |a Damonte, E.B. | |
| 700 | 1 | |a García, C.C. | |
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