Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection
Since natural products are considered powerful sources of novel drug discovery, a partially purified extract (meliacine) from the leaves of Melia azedarach L., a plant used in traditional medicine in India for the treatment of several diseases, has been studied. Meliacine exhibits a potent antiviral...
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2009
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 11480caa a22013817a 4500 | ||
|---|---|---|---|
| 001 | PAPER-23007 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205438.0 | ||
| 008 | 190411s2009 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-73449139459 | |
| 024 | 7 | |2 cas |a gamma interferon, 82115-62-6; Antiviral Agents; Interferon-gamma, 82115-62-6; Peptides; Plant Extracts; Plant Proteins; Tumor Necrosis Factor-alpha; meliacin | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PHYRE | ||
| 100 | 1 | |a Petrera, E. | |
| 245 | 1 | 0 | |a Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection |
| 260 | |c 2009 | ||
| 270 | 1 | 0 | |m Petrera, E.; Departamento de Química Biológica, Universidad de Buenos Aires, Ciudad Universitaria, Intendente Güiraldes 2160, C1428EGA, Buenos Aires, Argentina; email: epetrera@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Wachsman, M.B., Castilla, V., Coto, C.E., Inhibition of foot and mouth disease virus (FMDV) uncoating by a plant-derived peptide isolated from Melia azedarach L leaves (1998) Arch Virol, 143, pp. 581-590 | ||
| 504 | |a Wachsman, M.B., Damonte, E.B., Coto, C.E., de Torres, R.A., Antiviral effects of Melia azedarach L. leaves extracts on Sindbis virus-infected cells (1987) Antiviral Res, 8, pp. 1-12 | ||
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| 520 | 3 | |a Since natural products are considered powerful sources of novel drug discovery, a partially purified extract (meliacine) from the leaves of Melia azedarach L., a plant used in traditional medicine in India for the treatment of several diseases, has been studied. Meliacine exhibits a potent antiviral effect against several viruses without displaying cytotoxicity. The purpose of the present study was to evaluate the therapeutic effect of intravaginal administration of meliacine in a mouse model of genital herpetic infection. BALB/c female mice were infected with MS or G strains of Herpes Simplex Virus type 2 and then treated with meliacine topically. An overall protective effect was observed. Animal survival increased, the severity of the disease was reduced, life span was extended and virus shedding in vagina fluids was diminished. In addition, meliacine reduced the amount of virus that migrated to the brain and vaginal fluids presented higher levels of IFN- γ and TNF- α than untreated infected mice. These results indicate that meliacine could be an alternative therapeutic compound against HSV-2 genital infection. Copyright © 2009 John Wiley & Sons, Ltd. |l eng | |
| 593 | |a Departamento de Química Biológica, Universidad de Buenos Aires, Ciudad Universitaria, Intendente Güiraldes 2160, C1428EGA, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTIVIRAL |
| 690 | 1 | 0 | |a HSV-2 |
| 690 | 1 | 0 | |a MELIA AZEDARACH L. |
| 690 | 1 | 0 | |a MELIACINE |
| 690 | 1 | 0 | |a MICROBICIDE |
| 690 | 1 | 0 | |a MOUSE GENITAL INFECTION |
| 690 | 1 | 0 | |a GAMMA INTERFERON |
| 690 | 1 | 0 | |a MELIA AZEDARACH EXTRACT |
| 690 | 1 | 0 | |a MELIACINE |
| 690 | 1 | 0 | |a TUMOR NECROSIS FACTOR ALPHA |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ANTIVIRAL ACTIVITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DISEASE SEVERITY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENITAL HERPES |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS 2 |
| 690 | 1 | 0 | |a LIFESPAN |
| 690 | 1 | 0 | |a MELIA AZEDARACH |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a SURVIVAL |
| 690 | 1 | 0 | |a VAGINA DISCHARGE |
| 690 | 1 | 0 | |a VIRUS SHEDDING |
| 690 | 1 | 0 | |a VIRUS STRAIN |
| 690 | 1 | 0 | |a ADMINISTRATION, INTRAVAGINAL |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIVIRAL AGENTS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HERPES GENITALIS |
| 690 | 1 | 0 | |a HERPESVIRUS 2, HUMAN |
| 690 | 1 | 0 | |a INTERFERON-GAMMA |
| 690 | 1 | 0 | |a MEDICINE, TRADITIONAL |
| 690 | 1 | 0 | |a MELIA AZEDARACH |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a PEPTIDES |
| 690 | 1 | 0 | |a PHYTOTHERAPY |
| 690 | 1 | 0 | |a PLANT EXTRACTS |
| 690 | 1 | 0 | |a PLANT PROTEINS |
| 690 | 1 | 0 | |a TUMOR NECROSIS FACTOR-ALPHA |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a HUMAN HERPESVIRUS 2 |
| 690 | 1 | 0 | |a MELIA AZEDARACH |
| 690 | 1 | 0 | |a MUS |
| 650 | 1 | 7 | |2 spines |a VAGINA |
| 700 | 1 | |a Coto, C.E. | |
| 773 | 0 | |d 2009 |g v. 23 |h pp. 1771-1777 |k n. 12 |p Phytother. Res. |x 0951418X |t Phytotherapy Research | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0951418X_v23_n12_p1771_Petrera |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v23_n12_p1771_Petrera |y Registro en la Biblioteca Digital |
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