Stage dependent effects of progesterone on motoneurons and glial cells of wobbler mouse spinal cord degeneration

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In the Wobbler mouse, a mutation in the Vps54 gene is accompanied by motoneuron degeneration and astrogliosis in the cervical spinal cord. Previous work has shown that these abnormalities are greatly attenuated by progesterone treatment of clinically afflicted Wobblers. However, whether progesterone...

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Autor principal: Meyer, M.
Otros Autores: Gonzalez Deniselle, M.C, Garay, L.I, Monachelli, G.G, Lima, A., Roig, P., Guennoun, R., Schumacher, M., De Nicola, A.F
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2010
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 cas  |a choline acetyltransferase, 9012-78-6; glutamate ammonia ligase, 9023-70-5; progesterone, 57-83-0; Choline O-Acetyltransferase, 2.3.1.6; GAP-43 Protein; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase, 6.3.1.2; Progesterone, 57-83-0; RNA, Messenger 
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030 |a CMNED 
100 1 |a Meyer, M. 
245 1 0 |a Stage dependent effects of progesterone on motoneurons and glial cells of wobbler mouse spinal cord degeneration 
260 |c 2010 
270 1 0 |m De Nicola, A. F.; Instituto de Biologia y Medicina Experimental, CONICET, Laboratorio de Bioquimica Neuroendócrina, Obligado 2490, Buenos Aires 1428, Argentina; email: denicola@dna.uba.ar 
506 |2 openaire  |e Política editorial 
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504 |a Zoccolella, S., Beghi, E., Palagano, G., Fraddosio, A., Guerra, V., Samarelli, V., Lepore, V., Logroscino, G., Riluzole and amyotrophic lateral sclerosis survival: A population-based study in southern Italy (2007) European Journal of Neurology, 14 (3), pp. 262-268. , DOI 10.1111/j.1468-1331.2006.01575.x 
504 |a Zoing, M.C., Burke, D., Pamphlett, R., Kiernan, M.C., Riluzole therapy for motor neurone disease: An early Australian experience (1996-2002) (2006) Journal of Clinical Neuroscience, 13 (1), pp. 78-83. , DOI 10.1016/j.jocn.2004.04.011, PII S0967586805003693 
520 3 |a In the Wobbler mouse, a mutation in the Vps54 gene is accompanied by motoneuron degeneration and astrogliosis in the cervical spinal cord. Previous work has shown that these abnormalities are greatly attenuated by progesterone treatment of clinically afflicted Wobblers. However, whether progesterone is effective at all disease stages has not yet been tested. The present work used genotyped (wr/wr) Wobbler mice at three periods of the disease: early progressive (1-2 months), established (5-8 months) or late stages (12 months) and age-matched wildtype controls (NFR/NFR), half of which were implanted with a progesterone pellet (20 mg) for 18 days. In untreated Wobblers, degenerating vacuolated motoneurons were initially abundant, experienced a slight reduction at the established stage and dramatically diminished during the late period. In motoneurons, the cholinergic marker choline acetyltransferase (ChAT) was reduced at all stages of the Wobbler disease, whereas hyperexpression of the growth-associated protein (GAP43) mRNA preferentially occurred at the early progressive and established stages. Progesterone therapy significantly reduced motoneuron vacuolation, enhanced ChAT immunoreactive perikarya and reduced the hyperexpression of GAP43 during the early progressive and established stages. At all stage periods, untreated Wobblers showed high density of glial fibrillary acidic protein (GFAP)+ astrocytes and decreased number of glutamine synthase (GS) immunostained cells. Progesterone treatment down-regulated GFAP+ astrocytes and up-regulated GS+ cell number. These data reinforced the usefulness of progesterone to improve motoneuron and glial cell abnormalities of Wobbler mice and further showed that therapeutic benefit seems more effective at the early progressive and established periods, rather than on advance stages of spinal cord neurodegeneration. © 2009 Springer Science+Business Media, LLC.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires, M016, M611 
536 |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica, BID 1728 OC AR PICT 2004 5-25610, PICT 2007-01044 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 112-200801-00542 
536 |a Detalles de la financiación: Acknowledgments This work was supported by FONCYT (BID 1728 OC AR PICT 2004 5-25610 and PICT 2007-01044), CONICET (PIP 112-200801-00542), the University of Buenos Aires (M016 and M611) and a cooperative program INSERM/CONICET. 
593 |a Instituto de Biologia y Medicina Experimental, CONICET, Laboratorio de Bioquimica Neuroendócrina, Obligado 2490, Buenos Aires 1428, Argentina 
593 |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina 
593 |a UMR788 Inserm and University Paris-Sud 11, Kremlin-Bicêtre, France 
690 1 0 |a GLIAL FIBRILLARY ACIDIC PROTEIN 
690 1 0 |a GLUTAMINE SYNTHETASE 
690 1 0 |a NEURODEGENERATION 
690 1 0 |a NEUROPROTECTION 
690 1 0 |a PROGESTERONE 
690 1 0 |a WOBBLER 
690 1 0 |a CHOLINE ACETYLTRANSFERASE 
690 1 0 |a GLIAL FIBRILLARY ACIDIC PROTEIN 
690 1 0 |a GLUTAMATE AMMONIA LIGASE 
690 1 0 |a MESSENGER RNA 
690 1 0 |a NEUROMODULIN 
690 1 0 |a PROGESTERONE 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL MODEL 
690 1 0 |a ANIMAL TISSUE 
690 1 0 |a ARTICLE 
690 1 0 |a CELL DEGENERATION 
690 1 0 |a CHRONOTHERAPY 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DISEASE COURSE 
690 1 0 |a DRUG EFFICACY 
690 1 0 |a FEMALE 
690 1 0 |a GENOTYPE 
690 1 0 |a GLIA CELL 
690 1 0 |a MALE 
690 1 0 |a MOUSE 
690 1 0 |a MOUSE MUTANT 
690 1 0 |a NEUROPROTECTION 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN EXPRESSION 
690 1 0 |a SPINAL CORD ATROPHY 
690 1 0 |a SPINAL CORD MOTONEURON 
690 1 0 |a WILD TYPE 
690 1 0 |a WOBBLER MOUSE 
690 1 0 |a ANIMALS 
690 1 0 |a ANTERIOR HORN CELLS 
690 1 0 |a ASTROCYTES 
690 1 0 |a CELL COUNT 
690 1 0 |a CHOLINE O-ACETYLTRANSFERASE 
690 1 0 |a DISEASE MODELS, ANIMAL 
690 1 0 |a FEMALE 
690 1 0 |a GAP-43 PROTEIN 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a GENOTYPE 
690 1 0 |a GLIAL FIBRILLARY ACIDIC PROTEIN 
690 1 0 |a GLUTAMATE-AMMONIA LIGASE 
690 1 0 |a IMAGE PROCESSING, COMPUTER-ASSISTED 
690 1 0 |a MALE 
690 1 0 |a MICE 
690 1 0 |a MICE, NEUROLOGIC MUTANTS 
690 1 0 |a MOTOR NEURONS 
690 1 0 |a NEUROGLIA 
690 1 0 |a PROGESTERONE 
690 1 0 |a RNA, MESSENGER 
690 1 0 |a SPINAL CORD 
690 1 0 |a SPINAL CORD DISEASES 
690 1 0 |a MUS 
700 1 |a Gonzalez Deniselle, M.C. 
700 1 |a Garay, L.I. 
700 1 |a Monachelli, G.G. 
700 1 |a Lima, A. 
700 1 |a Roig, P. 
700 1 |a Guennoun, R. 
700 1 |a Schumacher, M. 
700 1 |a De Nicola, A.F. 
773 0 |d 2010  |g v. 30  |h pp. 123-135  |k n. 1  |p Cell. Mol. Neurobiol.  |x 02724340  |t Cellular and Molecular Neurobiology 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-76749135687&doi=10.1007%2fs10571-009-9437-8&partnerID=40&md5=0867d91faadbe83b157c54beaeb30c83  |y Registro en Scopus 
856 4 0 |u https://doi.org/10.1007/s10571-009-9437-8  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_02724340_v30_n1_p123_Meyer  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02724340_v30_n1_p123_Meyer  |y Registro en la Biblioteca Digital 
961 |a paper_02724340_v30_n1_p123_Meyer  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 83942 

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