Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: A study in mutant mice
The role of P/Q- and T-type calcium channels in the rhythmic oscillatory behaviour of inferior olive (IO) neurons was investigated in mutant mice. Mice lacking either the CaV2.1 gene of the pore-forming α1A subunit for P/Q-type calcium channel, or the CaV3.1 gene of the pore-forming α1G subunit for...
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2010
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| LEADER | 13798caa a22015617a 4500 | ||
|---|---|---|---|
| 001 | PAPER-22844 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205427.0 | ||
| 008 | 190411s2010 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-77955753406 | |
| 024 | 7 | |2 cas |a Cacna1a protein, mouse; Cacna1g protein, mouse; Calcium Channels, P-Type; Calcium Channels, Q-Type; Calcium Channels, T-Type | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JPHYA | ||
| 100 | 1 | |a Choi, S. | |
| 245 | 1 | 0 | |a Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: A study in mutant mice |
| 260 | |c 2010 | ||
| 270 | 1 | 0 | |m Llinás, R.R.; NYU School of Medicine, Physiology and Neuroscience, 550 First Ave, MSB 442, New York, NY 10016, United States; email: llinar01@med.nyu.edu |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The role of P/Q- and T-type calcium channels in the rhythmic oscillatory behaviour of inferior olive (IO) neurons was investigated in mutant mice. Mice lacking either the CaV2.1 gene of the pore-forming α1A subunit for P/Q-type calcium channel, or the CaV3.1 gene of the pore-forming α1G subunit for T-type calcium channel were used. In vitro intracellular recording from IO neurons reveals that the amplitude and frequency of sinusoidal subthreshold oscillations (SSTOs) were reduced in the CaV2.1-/- mice. In the CaV3.1-/- mice, IO neurons also showed altered patterns of SSTOs and the probability of SSTO generation was significantly lower (15%, 5 of 34 neurons) than that of wild-type (78%, 31 of 40 neurons) or CaV2.1-/- mice (73%, 22 of 30 neurons). In addition, the low-threshold calcium spike and the sustained endogenous oscillation following rebound potentials were absent in IO neurons from CaV3.1-/- mice. Moreover, the phase-reset dynamics of oscillatory properties of single neurons and neuronal clusters in IO were remarkably altered in both CaV2.1-/- and CaV3.1-/- mice. These results suggest that both α1A P/Q- and α1G T-type calcium channels are required for the dynamic control of neuronal oscillations in the IO. These findings were supported by results from a mathematical IO neuronal model that incorporated T and P/Q channel kinetics. © 2010 The Authors. Journal compilation © 2010 The Physiological Society. |l eng | |
| 593 | |a Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, United States | ||
| 593 | |a Institute of Physiology, Molecular Biology and Neuroscience (IFIBYNE), National Research Council (CONICET), Buenos Aires, Argentina | ||
| 593 | |a Department of Neuroscience, University of Science and Technology, Daejon 305-333, South Korea | ||
| 593 | |a Center for Neural Science, Korea Institute of Science and Technology, Seoul 136-791, South Korea | ||
| 593 | |a Department of Biological Science, Korea Advanced Institute of Science and Technology, Daejon 305-701, South Korea | ||
| 690 | 1 | 0 | |a CALCIUM CHANNEL |
| 690 | 1 | 0 | |a CALCIUM CHANNEL CAV2.1 |
| 690 | 1 | 0 | |a CALCIUM CHANNEL CAV3.1 |
| 690 | 1 | 0 | |a CALCIUM CHANNEL P TYPE |
| 690 | 1 | 0 | |a CALCIUM CHANNEL Q TYPE |
| 690 | 1 | 0 | |a CALCIUM CHANNEL T TYPE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a CALCIUM CHANNEL P TYPE |
| 690 | 1 | 0 | |a CALCIUM CHANNEL Q TYPE |
| 690 | 1 | 0 | |a CALCIUM CHANNEL T TYPE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ELECTRIC POTENTIAL |
| 690 | 1 | 0 | |a INFERIOR OLIVE |
| 690 | 1 | 0 | |a MATHEMATICAL MODEL |
| 690 | 1 | 0 | |a MEMBRANE POTENTIAL |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NERVE CELL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OSCILLATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
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| 690 | 1 | 0 | |a CELLULAR PARAMETERS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a INFERIOR OLIVE |
| 690 | 1 | 0 | |a INTRACELLULAR RECORDING |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MEMBRANE STEADY POTENTIAL |
| 690 | 1 | 0 | |a MOLECULAR IMAGING |
| 690 | 1 | 0 | |a NERVE CELL MEMBRANE POTENTIAL |
| 690 | 1 | 0 | |a PROTEIN FUNCTION |
| 690 | 1 | 0 | |a PROTEIN TRANSPORT |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a SINUSOIDAL SUBTHRESHOLD MEMBRANE POTENTIAL OSCILLATION |
| 690 | 1 | 0 | |a SPIKE WAVE |
| 690 | 1 | 0 | |a ANIMALS |
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| 690 | 1 | 0 | |a CALCIUM SIGNALING |
| 690 | 1 | 0 | |a COMPUTER SIMULATION |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a MEMBRANE POTENTIALS |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, KNOCKOUT |
| 690 | 1 | 0 | |a MODELS, NEUROLOGICAL |
| 690 | 1 | 0 | |a NEURONS |
| 690 | 1 | 0 | |a OLIVARY NUCLEUS |
| 700 | 1 | |a Yu, E. | |
| 700 | 1 | |a Kim, D. | |
| 700 | 1 | |a Urbano, F.J. | |
| 700 | 1 | |a Makarenko, V. | |
| 700 | 1 | |a Shin, H. | |
| 700 | 1 | |a Llinás, R.R. | |
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