VEGF and CD31 association in pituitary adenomas
Pituitary tumors are usually less vascularized than the normal pituitary, and the role of angiogenesis in these adenomas is contentious. Appraisal of microvascular density and expression of the potent angiogenic vascular endothelial growth factor (VEGF) by immunohistochemistry has yielded controvers...
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2010
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| 005 | 20230518205426.0 | ||
| 008 | 190411s2010 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-77956472773 | |
| 024 | 7 | |2 cas |a vasculotropin, 127464-60-2; Antigens, CD31; Tumor Markers, Biological; Vascular Endothelial Growth Factor A | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ENPAF | ||
| 100 | 1 | |a Cristina, C. | |
| 245 | 1 | 0 | |a VEGF and CD31 association in pituitary adenomas |
| 260 | |c 2010 | ||
| 270 | 1 | 0 | |m Becu-Villalobos, D.; Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, Buenos Aires 1428, Argentina; email: dbecu@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Lloyd, R.V., Vidal, S., Horvath, E., Kovacs, K., Scheithauer, B., Angiogenesis in normal and neoplastic pituitary tissues (2003) Microscopy Research and Technique, 60 (2), pp. 244-250. , DOI 10.1002/jemt.10263 | ||
| 520 | 3 | |a Pituitary tumors are usually less vascularized than the normal pituitary, and the role of angiogenesis in these adenomas is contentious. Appraisal of microvascular density and expression of the potent angiogenic vascular endothelial growth factor (VEGF) by immunohistochemistry has yielded controversial results, as a broad spectrum of immunostaining can be found. We determined the protein expression of VEGF and CD31, an endothelial marker, in a series of 56 surgically removed pituitary adenomas using Western blot assay. Prolactinomas had higher VEGF protein expression compared to nonfunctioning or ACTH- and GH-secreting adenomas, while CD31 was similar in the different adenoma histotypes. VEGF and CD31 were not affected by sex, age, years of adenoma evolution, or proliferation rate (Ki67 and PCNA) for all adenoma types. Only in nonfunctioning adenomas CD31 concentration increased significantly with age. There was a positive correlation between CD31 and VEGF expression when all adenoma histotypes were considered, or when prolactinomas and nonfunctioning adenomas were evaluated separately. The positive association of VEGF and CD31 expression suggests the participation of angiogenesis in adenoma development, while epithelial cell proliferation in pituitary tumors is not directly related to VEGF or CD31 expression, and other factors, such as primary genetic alterations may be involved. © 2010 Springer Science+Business Media, LLC. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Fundación Florencio Fiorini | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, N206, PICT 2006 | ||
| 536 | |a Detalles de la financiación: Fundación Alberto J. Roemmers | ||
| 536 | |a Detalles de la financiación: De Blindas Vänner | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 640 | ||
| 536 | |a Detalles de la financiación: CC and MIPM shared the work equally. C.Cristina.M.I.Perez-Millan.G.Luque.R.A.Dulce. D. Becu-Villalobos (*) Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina e-mail: dbecu@dna.uba.ar | ||
| 536 | |a Detalles de la financiación: Acknowledgments This work was supported by grants from CONICET (PIP 640 to DBV), Fundación Alberto J. Roemmers (DBV), Fundación Fiorini (DBV), and Agencia Nacional de Promoción Científica y Técnica, Buenos Aires, Argentina (PICT 2006, N206, to DBV). | ||
| 593 | |a Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, Buenos Aires 1428, Argentina | ||
| 593 | |a Universidad Nacional Del Noroeste de la Provincia de Buenos Aires (UNNOBA), Roque Sáenz Peña 456, 6000 Buenos Aires Junín, Argentina | ||
| 593 | |a Department of Neuropathology, Institute for Neurological Research FLENI, Montañeses 2325, Buenos Aires C1428AQK Buenos Aires, Argentina | ||
| 593 | |a Department of Neurosurgery, Hospital Santa Lucía, Buenos Aires 1232, Argentina | ||
| 690 | 1 | 0 | |a ANGIOGENESIS |
| 690 | 1 | 0 | |a CD31 |
| 690 | 1 | 0 | |a PELIOISIS |
| 690 | 1 | 0 | |a PITUITARY ADENOMA |
| 690 | 1 | 0 | |a PROLIFERATION |
| 690 | 1 | 0 | |a VEGF |
| 690 | 1 | 0 | |a CD31 ANTIGEN |
| 690 | 1 | 0 | |a CYCLINE |
| 690 | 1 | 0 | |a KI 67 ANTIGEN |
| 690 | 1 | 0 | |a VASCULOTROPIN |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGE |
| 690 | 1 | 0 | |a ANGIOGENESIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CARCINOGENESIS |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CORRELATION ANALYSIS |
| 690 | 1 | 0 | |a DISEASE COURSE |
| 690 | 1 | 0 | |a EPITHELIUM CELL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENDER |
| 690 | 1 | 0 | |a GROWTH HORMONE SECRETING ADENOMA |
| 690 | 1 | 0 | |a HISTOPATHOLOGY |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN TISSUE |
| 690 | 1 | 0 | |a HYPOPHYSIS ADENOMA |
| 690 | 1 | 0 | |a MAJOR CLINICAL STUDY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MUTATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROLACTINOMA |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a TUMOR GROWTH |
| 690 | 1 | 0 | |a WESTERN BLOTTING |
| 690 | 1 | 0 | |a ADENOMA |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ANTIGENS, CD31 |
| 690 | 1 | 0 | |a BLOTTING, WESTERN |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PITUITARY NEOPLASMS |
| 690 | 1 | 0 | |a TUMOR MARKERS, BIOLOGICAL |
| 690 | 1 | 0 | |a VASCULAR ENDOTHELIAL GROWTH FACTOR A |
| 700 | 1 | |a Perez-Millan, M.I. | |
| 700 | 1 | |a Luque, G. | |
| 700 | 1 | |a Dulce, R.A. | |
| 700 | 1 | |a Sevlever, G. | |
| 700 | 1 | |a Berner, S.I. | |
| 700 | 1 | |a Becu-Villalobos, D. | |
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