Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice
During aging the hippocampus experiences structural, molecular, and functional alterations. Protection from age-related disorders is provided by several factors, including estrogens. Since aging defects start at middle age, we studied if 17 β-estradiol (E2) protected the hippocampus at this age peri...
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2007
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| 001 | PAPER-22654 | ||
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| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-34248586492 | |
| 024 | 7 | |2 cas |a broxuridine, 59-14-3; cholesterol, 57-88-5; doublecortin, 202938-39-4; estradiol, 50-28-2; Estradiol, 50-28-2; Neuroprotective Agents | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PSYCD | ||
| 100 | 1 | |a Saravia, F. | |
| 245 | 1 | 0 | |a Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Saravia, F.; Laboratory of Neuroendocrine Biochemistry, Instituto de Biología y Medicina Experimental, 1428 Buenos Aires, Argentina; email: fsaravia@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a During aging the hippocampus experiences structural, molecular, and functional alterations. Protection from age-related disorders is provided by several factors, including estrogens. Since aging defects start at middle age, we studied if 17 β-estradiol (E2) protected the hippocampus at this age period. Middle age (10-12 month old) male C57Bl/6 mice were implanted sc with E2 (15 μg) or cholesterol pellets. Ten days afterwards they received bromodeoxyuridine (BrdU) 4 and 2 h before killing to study cell proliferation in the dentate gyrus (DG). A pronounced depletion of BrdU+cells in the DG was found in cholesterol-treated middle age mice, accompanied by astrocytosis, and by neuronal loss in the hilus. Middle age mice receiving E2 showed increased number of BrdU+cells while the other parameters were remarkably attenuated. When steroid treatment was prolonged for 2 months to study migration of cells in the granular layer of the DG, cell migration was unaffected by E2. However, E2-treated middle age mice presented higher cell density and increased staining for doublecortin, a marker for differentiating neurons. Thus, from the three basic steps of adult neurogenesis (proliferation, migration, and differentiation), E2 stimulated progenitor proliferation-even after long exposure to E2 studied by Ki67 immunocytochemistry-and differentiation towards a neuronal lineage. This result, in conjunction with recovery from other aging indicators as increased deposits of the aging pigment lipofuscin in DG cells, loss of hilar neurons and astrocytosis supports a wide range protection of hippocampal function of middle age mice by estrogenic hormones. © 2007 Elsevier Ltd. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, M094, M022 | ||
| 536 | |a Detalles de la financiación: National Council for Scientific Research | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 5542 | ||
| 536 | |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica, BID 802 OC AR PICT 2000 05-08663 | ||
| 536 | |a Detalles de la financiación: FONCYT (BID 802 OC AR PICT 2000 05-08663), the National Research Council of Argentina (CONICET, PIP 5542) and the University of Buenos Aires (M022 and M094). | ||
| 593 | |a Laboratory of Neuroendocrine Biochemistry, Instituto de Biología y Medicina Experimental, 1428 Buenos Aires, Argentina | ||
| 593 | |a Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, 1033 Buenos Aires, Argentina | ||
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| 690 | 1 | 0 | |a DOUBLECORTIN |
| 690 | 1 | 0 | |a ESTRADIOL |
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| 690 | 1 | 0 | |a NEUROGENESIS |
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