Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support

Nucleoside analogue synthesis has received much attention because of the wide range of applications that these molecules offer. They are extensively used as antiviral, antitumor and more recently, as starting materials for functional oligonucleotides. Microbial whole cells are efficient, ecological...

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Autor principal: Trelles, J.A
Otros Autores: Bentancor, L., Grasselli, M., Lewkowicz, E.S, Iribarren, A.M
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2008
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
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024 7 |2 cas  |a polyethylene, 9002-88-4 
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100 1 |a Trelles, J.A. 
245 1 0 |a Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support 
260 |c 2008 
270 1 0 |m Trelles, J.A.; Universidad Nacional de Quilmes, Roque Saenz Peña 352, 1876 Bernal Buenos Aires, Argentina; email: jtrelles@unq.edu.ar 
506 |2 openaire  |e Política editorial 
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504 |a Ferrero, M., Gotor, V., (2000) Chem. Rev., 100, pp. 4319-4347 
504 |a Lewkowicz, E., Iribarren, A., (2006) Curr. Org. Chem., 10, pp. 1197-1215 
504 |a Prasad, A.K., Trikha, S., Parmar, V.S., (1999) Bioorg. Chem., 27, pp. 135-154 
504 |a Utagawa, T., (1999) J. Mol. Catal. B: Enzym., 6, pp. 215-222 
504 |a Trelles, J.A., Lewkowicz, E.S., Sinisterra, J.V., Iribarren, A.M., (2004) Int. J. Biotechnol., 6, pp. 376-384 
504 |a Trelles, J.A., Bentancor, L., Schoijet, A., Porro, S., Lewkowicz, E.S., Sinisterra, J.V., Iribarren, A.M., (2004) Chem. Biodivers., 1, pp. 280-288 
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504 |a Lewkowicz, E., Martínez, N., Rogert, M.C., Porro, S., Iribarren, A.M., (2000) Biotechnol. Lett., 22, pp. 1277-1280 
504 |a Rogert, M.C., Trelles, J.A., Porro, S., Lewkowicz, E.S., Iribarren, A.M., (2002) Biocatal. Biotransform., 20, pp. 347-351 
504 |a Grasselli, M., Carbajal, M.L., Yoshii, F., Sugo, T., (2003) J. Appl. Polym. Sci., 87, pp. 1646-1653 
504 |a Grasselli, M., Navarro del Cañizo, A.A., Camperi, A.A., Wolman, F.J., Smolko, E.E., Cascone, O., (1999) Radiat. Phys. Chem., 55, pp. 203-208 
504 |a Lee, W., Saito, K., Furusaki, S., Sugo, T., (1997) Biotechnol. Bioeng., 53, pp. 523-528 
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504 |a Mateo, C., Palomo, J.M., Fernandez-Lorente, G., Guisan, J.M., Fernandez-Lafuente, R., (2007) Enzyme Microb. Technol., 40, pp. 1451-1463 
504 |a Cao, L., (2005) Curr. Opin. Chem. Biol., 9, pp. 217-226 
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520 3 |a Nucleoside analogue synthesis has received much attention because of the wide range of applications that these molecules offer. They are extensively used as antiviral, antitumor and more recently, as starting materials for functional oligonucleotides. Microbial whole cells are efficient, ecological and low cost biocatalysts that have been successfully applied to the preparation of these compounds. A new support for cell immobilization that involves the use of a macroporous polyethylene polymer grafted with chains of polyglycidyl methacrylate-ethylendiamine is described in this paper. High stability and productivity and easy handling are some of the advantages of the here developed biocatalyst. © 2007 Elsevier B.V. All rights reserved.  |l eng 
536 |a Detalles de la financiación: Universidad Nacional de Quilmes 
536 |a Detalles de la financiación: Secretaría de Ciencia y Técnica, Universidad de Buenos Aires 
536 |a Detalles de la financiación: This work was supported by Universidad Nacional de Quilmes, SantanderRio-Universia and Secretaría de Ciencia y Técnica de la Nación, Argentina. 
593 |a Universidad Nacional de Quilmes, Roque Saenz Peña 352, 1876 Bernal Buenos Aires, Argentina 
593 |a INGEBI, CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina 
690 1 0 |a ADENOSINE 
690 1 0 |a ESCHERICHIA COLI BL21 
690 1 0 |a NUCLEOSIDE PHOSPHORYLASES 
690 1 0 |a POLYETHYLENE 
690 1 0 |a WHOLE CELL IMMOBILIZATION 
690 1 0 |a ADENOSINE 
690 1 0 |a ANTITUMORS 
690 1 0 |a NUCLEOSIDE PHOSPHORYLASES 
690 1 0 |a NUCLEOSIDES 
690 1 0 |a CELL IMMOBILIZATION 
690 1 0 |a ENZYMES 
690 1 0 |a ESCHERICHIA COLI 
690 1 0 |a GRAFT COPOLYMERS 
690 1 0 |a SYNTHESIS (CHEMICAL) 
690 1 0 |a POLYETHYLENES 
690 1 0 |a ANTINEOPLASTIC AGENT 
690 1 0 |a ANTISENSE OLIGONUCLEOTIDE 
690 1 0 |a ANTIVIRUS AGENT 
690 1 0 |a NUCLEOSIDE 
690 1 0 |a OLIGONUCLEOTIDE 
690 1 0 |a POLYETHYLENE 
690 1 0 |a POLYGLYCIDYL METHACRYLATE ETHYLENEDIAMINE 
690 1 0 |a POLYMER 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a ARTICLE 
690 1 0 |a BIOCATALYST 
690 1 0 |a CATALYST SUPPORT 
690 1 0 |a COST MINIMIZATION ANALYSIS 
690 1 0 |a DRUG SYNTHESIS 
690 1 0 |a IMMOBILIZED CELL 
690 1 0 |a MOLECULAR STABILITY 
690 1 0 |a NUCLEIC ACID SYNTHESIS 
690 1 0 |a PHARMACEUTICAL ENGINEERING 
690 1 0 |a POROSITY 
690 1 0 |a PROCESS DEVELOPMENT 
690 1 0 |a PRODUCTIVITY 
690 1 0 |a ESCHERICHIA COLI 
700 1 |a Bentancor, L. 
700 1 |a Grasselli, M. 
700 1 |a Lewkowicz, E.S. 
700 1 |a Iribarren, A.M. 
773 0 |d 2008  |g v. 52-53  |h pp. 189-193  |k n. 1-4  |p J. Mol. Catal. B Enzym.  |x 13811177  |w (AR-BaUEN)CENRE-5687  |t Journal of Molecular Catalysis B: Enzymatic 
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