MMTV-induced pregnancy-dependent mammary tumors: Early history and new perspectives
Almost 60 years ago, Foulds carefully described for the first time a particular type of mouse mammary tumor that appeared in the glands of pregnant females and disappeared shortly after delivery. Since then, the attention that researchers paid to the Mouse Mammary Tumor Virus (MMTV)-induced pregnanc...
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2008
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| 100 | 1 | |a Kordon, E.C. | |
| 245 | 1 | 0 | |a MMTV-induced pregnancy-dependent mammary tumors: Early history and new perspectives |
| 260 | |c 2008 | ||
| 270 | 1 | 0 | |m Kordon, E.C.; Institute of Physiology, Molecular Biology and Neurosciences, School of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina; email: ekordon@qb.feen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Almost 60 years ago, Foulds carefully described for the first time a particular type of mouse mammary tumor that appeared in the glands of pregnant females and disappeared shortly after delivery. Since then, the attention that researchers paid to the Mouse Mammary Tumor Virus (MMTV)-induced pregnancy-dependent tumors has not vanished through the years. This was because the information obtained from mice carrying MMTV variants that were able to induce pregnancy-dependent tumors was meaningful for studying different aspects of mammary tumor biology. In addition, mice infected with these viral variants provided some of the few chances to use fully hormone-dependent estrogen receptor positive breast cancer models in the mouse. In the analysis of the association between tumor morphology and behavior, the mechanisms underlying progression towards autonomy, the impact of different genes during cancer initiation and development, and the relevance of host genetic background for tumor incidence and hormone-dependence, mouse strains carrying these MMTV variants have been very important tools that could not have been replaced with any other available model. The goal of this article is to provide a succinct chronicle of the experiments and observations made in the MMTV-induced pregnancy-dependent models that most significantly contributed to the mouse mammary tumor biology field. In addition, the possibility to use these MMTV variants as alternative models for analyzing mammary tumor stem cells and pregnancy-associated breast cancer in women is discussed. © Springer Science+Business Media, LLC 2008. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Universiteit Stellenbosch, R01-TW06212 | ||
| 536 | |a Detalles de la financiación: National Institutes of Health | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Acknowledgments The author would like to thank Dr. Omar A. Coso for critically reading the manuscript. ECK receives research support from CONICET and the Agencia Nacional de Promoción Científica y Tecnológica, Argentina and from the Fogarty Fundation, National Institutes of Health, US (grant R01-TW06212). | ||
| 593 | |a Institute of Physiology, Molecular Biology and Neurosciences, School of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Expresión Génica en Mama y Apoptosis (LEGMA), Facultad de Cs. Exactas y Naturales, Pabellón 2, 2do piso, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a HORMONE DEPENDENCY |
| 690 | 1 | 0 | |a MAMMARY TUMORS |
| 690 | 1 | 0 | |a MMTV |
| 690 | 1 | 0 | |a TUMOR PROGRESSION |
| 690 | 1 | 0 | |a ESTROGEN RECEPTOR |
| 690 | 1 | 0 | |a PROGESTERONE RECEPTOR |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BREAST CANCER |
| 690 | 1 | 0 | |a BREAST CARCINOGENESIS |
| 690 | 1 | 0 | |a BREAST TUMOR |
| 690 | 1 | 0 | |a CANCER INVASION |
| 690 | 1 | 0 | |a CANCER MODEL |
| 690 | 1 | 0 | |a CANCER STEM CELL |
| 690 | 1 | 0 | |a GENE MUTATION |
| 690 | 1 | 0 | |a GENE OVEREXPRESSION |
| 690 | 1 | 0 | |a HORMONE DEPENDENCE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a MOUSE MAMMARY TUMOR ONCOVIRUS |
| 690 | 1 | 0 | |a MOUSE STRAIN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a STRAIN DIFFERENCE |
| 690 | 1 | 0 | |a TUMOR GROWTH |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a DISEASE MODELS, ANIMAL |
| 690 | 1 | 0 | |a DISEASE PROGRESSION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HISTORY, 20TH CENTURY |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MAMMARY NEOPLASMS, EXPERIMENTAL |
| 690 | 1 | 0 | |a MAMMARY TUMOR VIRUS, MOUSE |
| 690 | 1 | 0 | |a MEDICAL ONCOLOGY |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MODELS, GENETIC |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RISK FACTORS |
| 690 | 1 | 0 | |a SPECIES SPECIFICITY |
| 651 | 4 | |a BREAST HYPERPLASIA | |
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