Are antigen test kits efficient for detecting heartworm-infected dogs at the southern distribution limit of the parasite in South America? Preliminary results

The aim of this study was to evaluate the performance of commercial heartworm antigen tests in dogs harbouring Dirofilaria immitis microfilariae near its distribution limit in South America. A total of 4934 blood samples of adult dogs from Southern Greater Buenos Aires were examined to detect circul...

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Autor principal: Vezzani, D.
Otros Autores: Fontanarrosa, M.F, Eiras, D.F
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2008
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Acceso en línea:Registro en Scopus
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024 7 |2 scopus  |a 2-s2.0-43849107291 
024 7 |2 cas  |a acid phosphatase, 9001-77-8, 9025-88-1; Reagent Kits, Diagnostic 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a RVTSA 
100 1 |a Vezzani, D. 
245 1 4 |a Are antigen test kits efficient for detecting heartworm-infected dogs at the southern distribution limit of the parasite in South America? Preliminary results 
260 |c 2008 
270 1 0 |m Eiras, D.F.; Laboratorio DIAP (Diagnóstico en Animales Pequeños), Inca 109, (B1836BBC), Llavallol, Buenos Aires, Argentina; email: diap@diap.com.ar 
506 |2 openaire  |e Política editorial 
504 |a Aranda, C., Panyella, O., Eritja, R., Castella, J., Canine filariasis. Importance and transmission in the Baix Lobregat area, Barcelona (Spain) (1998) Veterinary Parasitology, 77, pp. 267-275 
504 |a Atkins, C.E., Comparison of results of three commercial heartworm antigen test kits in dogs with low heartworm burdens (2003) Journal of the American Veterinary Medical Association, 222, pp. 1221-1223 
504 |a Casiraghi, M., Bazzocchi, C., Mortarino, M., Ottina, E., Genchi, C., A simple molecular method for discriminating common filarial nematodes of dogs (Canis familiaris) (2006) Veterinary Parasitology, 141, pp. 368-372 
504 |a Chalifoux, L., Hunt, R.D., Histochemical differentiation of Dirofilaria immitis and Dipetalonema reconditum (1971) Journal of the American Veterinary Medical Association, 158, pp. 601-605 
504 |a Courtney, C.H., Cornell, J.A., Evaluation of heartworm immunodiagnostic tests (1990) Journal of the American Veterinary Medical Association, 197, pp. 724-729 
504 |a Courtney, C.H., Zeng, Q.Y., Relationship between microfilaria count and sensitivity of the direct smear for diagnosis of canine dirofilariosis (2001) Veterinary Parasitology, 94, pp. 199-204 
504 |a Genchi, C., Venco, L., Genchi, M., Guideline for the laboratory diagnosis of canine and feline Dirofilaria infections (2007) Mappe Parassitologiche, 8, pp. 139-144 
504 |a Goodwin, J., The serologic diagnosis of heartworm infection in dogs and cats (1998) Clinical Techniques in Small Animal Practice, 13, pp. 83-87 
504 |a IGM, 1998. Atlas Geográfico de la República Argentina. Instituto Geográfico Militar, Buenos Aires, 95 pp; INDEC, 2001. Censo Nacional de Población, Hogares y Viviendas 2001. Instituto Nacional de Estadísticas y Censos (INDEC), Ministerio de Economía y Producción, República Argentina; Kaiser, L., Williams, J., Dirofilaria immitis: worm burden and pulmonary artery proliferation in dogs from Michigan (United States) (2004) Veterinary Parasitology, 124, pp. 125-129 
504 |a Klotins, K.C., Martin, S.W., Bonnett, B.N., Peregrine, A.S., Canine heartworm testing in Canada: are we being effective? (2000) Canadian Veterinary Journal, 41, pp. 929-937 
504 |a Labbé, J., Castronuovo, A.., Labbé, C., Velásquez, J., 1995. Morbilidad de Dirofilaria immitis en canes de los partidos de Lanus y Lomas de Zamora. In: Primer Congreso Latinoamericano de Zoonosis, Buenos Aires, p. 187; Martini, M., Capelli, G., Poglayen, G., Bertotti, F., Turilli, C., The validity of some haematological and elisa methods for the diagnosis of canine heartworm disease (1996) Veterinary Research Communications, 20, pp. 331-339 
504 |a Miller, M.W., Canine heartworm disease (1998) Clinical Techniques in Small Animal Practice, 13, pp. 113-118 
504 |a Nelson, C.T., McCall, J.W., Rubin, S.B., Buzhardt, L.F., Doiron, D.W., Graham, W., Longhofer, S.L., Paul, A., 2005 Guidelines for the diagnosis, prevention and management of heartworm (Dirofilaria immitis) infection in dogs (2005) Veterinary Parasitology, 133, pp. 255-266 
504 |a Rishniw, M., Barr, S.C., Simpson, K.W., Frongillo, M.F., Franz, M., Alpizar, J.L.D., Discrimination between six species of canine microfilariae by a single polymerase chain reaction (2006) Veterinary Parasitology, 135, pp. 303-314 
504 |a Tarello, W., 2001. Importance in the dog of concentration tests for the diagnosis of heartworm disease in non-endemic areas. Vet On-Line 2, available at <http://www.priory.com/vet/cardioworm.htm/>; Vezzani, D., Carbajo, A.E., Spatial and temporal transmission risk of Dirofilaria immitis in Argentina (2006) International Journal for Parasitology, 26, pp. 1463-1472 
504 |a Vezzani, D., Eiras, D.F., Wisnivesky, C., Dirofilariasis in Argentina: historical review and first report of Dirofilaria immitis in a natural mosquito population (2006) Veterinary Parasitology, 136, pp. 259-273 
520 3 |a The aim of this study was to evaluate the performance of commercial heartworm antigen tests in dogs harbouring Dirofilaria immitis microfilariae near its distribution limit in South America. A total of 4934 blood samples of adult dogs from Southern Greater Buenos Aires were examined to detect circulating microfilariae in the buffy coat interface between December 2005 and April 2006. Microfilariae were detected in 88 (1.8%) blood samples and all the microfilariae observed were identified as D. immitis by acid phosphatase stain technique. In a first trial, 69 (78.4%) out of the 88 serum were positive by Speed® Diro. Then, a new test was performed over 25 microfilariae-positive serum samples randomly selected among the 88 previously tested samples and using simultaneously Speed® Diro, Witness® Dirofilaria and Snap® 3dx. This second trial showed identical results for the three different tests, in which 19 (76%) samples were positive. Therefore, more than 20% of microfilaremic dogs were antigen negative. The main hypothesis that could explain our finding is a low worm burden in the study area. According to our preliminary results, it is highly recommendable the complementary use of antigen tests and other procedures to obtain an accurate diagnostic near the distribution limit of the parasite. © 2007 Elsevier Ltd. All rights reserved.  |l eng 
593 |a Ecología de Reservorios y Vectores de Parásitos, Facultad de Cs. Exactas y Naturales, Universidad de Buenos Aires, Argentina 
593 |a Laboratorio DIAP (Diagnóstico en Animales Pequeños), Inca 109, (B1836BBC), Llavallol, Buenos Aires, Argentina 
593 |a Cátedra de Parasitología y Enfermedades Parasitarias, Departamento de Microbiología, Facultad de Ciencias Veterinarias, CC 296, B1900AVW La Plata, Argentina 
651 4 |a ARGENTINA 
651 4 |a ARGENTINA 
651 4 |a SOUTH AMERICA 
690 1 0 |a COMMERCIAL HEARTWORM ANTIGEN TEST KITS 
690 1 0 |a DIROFILARIA IMMITIS 
690 1 0 |a EFFICIENCY 
690 1 0 |a ACID PHOSPHATASE 
690 1 0 |a PARASITE ANTIGEN 
690 1 0 |a ANIMAL PARASITOSIS 
690 1 0 |a ANTIGEN DETECTION 
690 1 0 |a ARTICLE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DIAGNOSTIC ACCURACY 
690 1 0 |a DIAGNOSTIC VALUE 
690 1 0 |a DIROFILARIA IMMITIS 
690 1 0 |a DOG 
690 1 0 |a HYPOTHESIS 
690 1 0 |a IMMUNOASSAY 
690 1 0 |a INTERMETHOD COMPARISON 
690 1 0 |a MICROFILARIASIS 
690 1 0 |a NONHUMAN 
690 1 0 |a PARASITE IDENTIFICATION 
690 1 0 |a PARASITE PREVALENCE 
690 1 0 |a ANIMALS 
690 1 0 |a DIROFILARIASIS 
690 1 0 |a DOG DISEASES 
690 1 0 |a DOGS 
690 1 0 |a PREDICTIVE VALUE OF TESTS 
690 1 0 |a REAGENT KITS, DIAGNOSTIC 
690 1 0 |a CANIS FAMILIARIS 
690 1 0 |a DIROFILARIA 
690 1 0 |a DIROFILARIA IMMITIS 
653 0 0 |a Snap 3dx, Idexx, United States; Speed Diro, Bio Veto Test, France; Witness, Synbiotics, United States 
700 1 |a Fontanarrosa, M.F. 
700 1 |a Eiras, D.F. 
773 0 |d 2008  |g v. 85  |h pp. 113-115  |k n. 1  |p Res. Vet. Sci.  |x 00345288  |t Research in Veterinary Science 
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856 4 0 |u https://doi.org/10.1016/j.rvsc.2007.08.001  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00345288_v85_n1_p113_Vezzani  |y Handle 
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