Altered protein mannosylation in developing cerebral cortex by streptomycin

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Our research objective was to characterize the biochemical effect of streptomycin during postnatal rat cerebral cortex development using a sensitive method that preserves the in situ topological relationship. We found a decrease in the mannosylation of asparagine-linked oligosaccharides without affe...

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Detalles Bibliográficos
Autor principal: Alperin, M.D
Otros Autores: Calandria, J.M, Carminatti, H., Idoyaga-Vargas, V.P
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Lippincott Williams and Wilkins 2000
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-0034626940 
024 7 |2 cas  |a carbon 14, 14762-75-5; DNA, 9007-49-2; glucose, 50-99-7, 84778-64-3; mannose, 31103-86-3, 3458-28-4; streptomycin, 57-92-1; tritium, 10028-17-8 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a NERPE 
100 1 |a Alperin, M.D. 
245 1 0 |a Altered protein mannosylation in developing cerebral cortex by streptomycin 
260 |b Lippincott Williams and Wilkins  |c 2000 
270 1 0 |m Idoyaga-Vargas, V.P.; Instituto de Investigaciones, Bioquimicas Fundacion Campomar, FCEyN UBA, Avda Patricias Argentinas 435, Capital Federal CP1405, Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Priuska, E.M., Schacht, J., (1997) ENT, 76, pp. 164-171 
504 |a Schacht, J., (1993) Otolaryngol Clin North Am, 26, pp. 845-856 
504 |a Harvey, S.C., Li, X., Skolnick, P., Kirst, H.A., (2000) Eur J Pharmacol, 387, pp. 1-7 
504 |a Dumitrescu, S., Crigghel, E., (1979) Ach Int Pharmacodyn Ther, 237, pp. 230-236 
504 |a Alperin, M.D., Idoyaga-Vargas, V., Carminatti, H., (1986) J Neurochem, 47, pp. 355-362 
504 |a Radrizzani, M., Carminatti, H., Idoyaga-Vargas, V., (1995) J Neurosci Res, 42, pp. 220-227 
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504 |a Audesirk, G., Audesirk, T., Ferguson, C., (1990) Brain Res Dev Brain Res, 55, pp. 109-120 
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504 |a Tower, D.B., Cerebral edema (1976), pp. 627-645. , Siegel GJ, Wayne Albers R, Katzman R. and Agranoff B, eds. Basic Neurochemistry Boston, MA: Little Brown; Yakisich, S., Siden, A., Idoyaga-Vargas, V., (1998) Exp Neurol, 15, pp. 194-202 
504 |a Idoyaga-Vargas, V., Carminatti, H., (1982) Biochem J, 202, pp. 87-95 
504 |a Lowry, M., Rosebrough, N.J., Farr, A.L., (1951) J Biol Chem, 193, pp. 265-275 
504 |a Rothman, J., Lodish, H., (1977) Nature, 269, pp. 775-780 
504 |a Segal, J.A., Harris, B.D., Kustova, Y., (1999) Brain Res, 815, pp. 270-277 
504 |a Lopez-Gonzales, M., Delgado, F., Lucas, M., (1999) Hear Res, 136, pp. 165-168 
504 |a De la Rosa-Galvez, A., Jauregui-Renaud, K., Hernandez-Gorihar, M., (1998) Gac Med Mex, 134, pp. 705-711 
504 |a Tessier-Lavigne, M., Goodman, C., (1996) Science, 274, pp. 1123-1132 
504 |a Yakisich, J.S., Radrizzani, M., Idoyaga-Vargas, V., (1994) Neurosci Lett, 180, pp. 17-20 
504 |a Idoyaga-Vargas, V., Yakisich, J.S., Boethius, J., (1997) J Neurol Sci, 150, pp. S195 
504 |a Yakisich, S., Siden, A., Idoyaga-Vargas, V., (1998) Biochem Biophys Res Commun, 243, pp. 674-677 
504 |a Yakisich, J.S., Boethius, J., Lindblom, I.O., (1999) Neuroreport, 10, pp. 2563-2567 
504 |a Yakisich, J.S., Siden, A., Eneroth, P., (1999) Exp Neurol, 159, pp. 164-176 
520 3 |a Our research objective was to characterize the biochemical effect of streptomycin during postnatal rat cerebral cortex development using a sensitive method that preserves the in situ topological relationship. We found a decrease in the mannosylation of asparagine-linked oligosaccharides without affecting polypeptide synthesis, DNA synthesis or glucose and mannose disappearance from the medium in mini-tissue units derived from P5. In addition, the rate of Dolp-GlcNAc2Man9Glc3 synthesis and the oligosaccharide protein transferase activity did not change in the presence of the aminoglycoside. These findings strongly suggested that the alteration of protein mannosylation occurred downstream of G3 transfer to nascent polypeptides. Further, the mini-tissue units may be useful for the assessment of neurological toxicity of antibacterial agents. (C) 2000 Lippincott Williams and Wilkins.  |l eng 
593 |a Instituto de Investigaciones, Bioquimicas Fundacion Campomar, FCEyN UBA, Avda Patricias Argentinas 435, Capital Federal CP1405, Buenos Aires, Argentina 
690 1 0 |a CEREBRAL CORTEX 
690 1 0 |a MINI-TISSUE UNITS 
690 1 0 |a NEUROTOXICITY 
690 1 0 |a PROTEIN GLYCOSYLATION 
690 1 0 |a STREPTOMYCIN 
690 1 0 |a AMINOGLYCOSIDE ANTIBIOTIC AGENT 
690 1 0 |a ANTIBIOTIC AGENT 
690 1 0 |a ASPARAGINE LINKED OLIGOSACCHARIDE 
690 1 0 |a CARBON 14 
690 1 0 |a DNA 
690 1 0 |a GLUCOSE 
690 1 0 |a MANNOSE 
690 1 0 |a STREPTOMYCIN 
690 1 0 |a TRITIUM 
690 1 0 |a ANIMAL TISSUE 
690 1 0 |a ARTICLE 
690 1 0 |a BRAIN CORTEX 
690 1 0 |a BRAIN DEVELOPMENT 
690 1 0 |a CONCENTRATION RESPONSE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DNA SYNTHESIS 
690 1 0 |a NERVOUS SYSTEM DEVELOPMENT 
690 1 0 |a NEUROTOXICITY 
690 1 0 |a NEWBORN 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN GLYCOSYLATION 
690 1 0 |a PROTEIN SYNTHESIS 
690 1 0 |a RAT 
700 1 |a Calandria, J.M. 
700 1 |a Carminatti, H. 
700 1 |a Idoyaga-Vargas, V.P. 
773 0 |d Lippincott Williams and Wilkins, 2000  |g v. 11  |h pp. 3569-3572  |k n. 16  |p NeuroReport  |x 09594965  |w (AR-BaUEN)CENRE-6274  |t NeuroReport 
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856 4 0 |u https://doi.org/10.1097/00001756-200011090-00033  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_09594965_v11_n16_p3569_Alperin  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v11_n16_p3569_Alperin  |y Registro en la Biblioteca Digital 
961 |a paper_09594965_v11_n16_p3569_Alperin  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 63181 

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