Withanolides from Vassobia lorentzii
Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epox...
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| Otros Autores: | , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2000
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 05053caa a22008057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2225 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203137.0 | ||
| 008 | 190411s2000 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0033753895 | |
| 024 | 7 | |2 cas |a withanolide, 40326-62-3; Antimalarials; Ergosterol, 57-87-4; Lactones | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JNPRD | ||
| 100 | 1 | |a Misico, R.I. | |
| 245 | 1 | 0 | |a Withanolides from Vassobia lorentzii |
| 260 | |c 2000 | ||
| 270 | 1 | 0 | |m Burton, G.; Dept. de Quimica Organica, Facul. de Ciencias Exactas y Nat., Universidad de Buenos Aires, Pabellon 2, 1428 Buenos Aires, Argentina; email: burton@qo.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Hunziker, A.T., (1984) Kurtziana, 17, pp. 91-118 | ||
| 504 | |a Silva, G.L., Burton, G., Oberti, J.C., (1999) J. Nat. Prod., 62, pp. 949-953 | ||
| 504 | |a Glotter, E., Kirson, I., Abraham, A., Subramanian, S.S., Sethi, P.D., (1975) J. Chem. Soc., Perkin Trans. 1, pp. 1370-1374 | ||
| 504 | |a Ray, A.B., Gupta, M., (1994) Prog. Chem. Org. Nat. Prod., 63, pp. 1-106 | ||
| 504 | |a Conta, A.G., Albonico, S.M., Juliani, H.R., (1971) An. Asoc. Quim. Argent., 59, pp. 373-375 | ||
| 504 | |a Kupchan, S.M., Anderson, W.K., Bollinger, P., Doskotch, R.W., Smith, R.M., Saenz Renauld, J.A., Schnols, H.K., Smith, D.H., (1969) J. Org. Chem., 34, pp. 3858-3866 | ||
| 504 | |a Nittala, S.S., Lavie, D., (1981) Phytochemistry, 20, pp. 2735-2739 | ||
| 504 | |a Shingu, K., Miyagawa, M., Yahara, S., Nohara, T., (1993) Chem. Pharm. Bull., 41, pp. 1873-1875 | ||
| 504 | |a Sinha, S.C., Ray, A.B., Oshima, Y., Bagchi, A., Hikino, H., (1987) Phytochemistry, 26, pp. 2115-2117 | ||
| 504 | |a Raffauf, R.F., Shemluck, M.J., Lequesne, P.W., (1991) J. Nat. Prod., 54, pp. 1601-1606 | ||
| 520 | 3 | |a Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epoxy-4β,18-dihydroxy-1-oxowitha-2,5,24-trienolide (2); (17S,18R,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (3); (17S,18S,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (4); (17S,20R,22R)-4β-hydroxy-18,20-epoxy-1,18-dioxowitha-2,5,24-trienolide (5); (17S,18R,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (6); (17S,18S,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (7); and (17S,20R,22R)-5β,6β-epoxy-4β,18,20-trihydroxy-1-oxowitha-2,24-dienolide (8). Compounds 1 and 2 were obtained as epimeric mixtures at C-18. |l eng | |
| 593 | |a Departamento de Química Orgánica and IMBIV, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina | ||
| 593 | |a Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 18,20 EPOXY 18 METHOXY 1,4 DIOXOWITHA 2,5,24 TRIENOLIDE |
| 690 | 1 | 0 | |a 18,20 EPOXY 4BETA,18 DIHYDROXY 1 OXOWITHA 2,5,24 TRIENOLIDE |
| 690 | 1 | 0 | |a 4BETA HYDROXY 18,20 EPOXY 1,18 DIOXOWITHA 2,5,24 TRIENOLIDE |
| 690 | 1 | 0 | |a 4BETA HYDROXY 18,20 EPOXY 18 METHOXY 1 OXOWITHA 2,5,24 TRIENOLIDE |
| 690 | 1 | 0 | |a 5BETA,6BETA EPOXY 4BETA,18,20 TRIHYDROXY 1 OXOWITHA 2,24 DIENOLIDE |
| 690 | 1 | 0 | |a 5BETA,6BETA:18,20 DIEPOXY 18 HYDROXY 1 OXOWITHA 2,5,24 TRIENOLIDE |
| 690 | 1 | 0 | |a PLANT EXTRACT |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a VASSOBIA LORENTZII EXTRACT |
| 690 | 1 | 0 | |a WITHANOLIDE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHEMICAL STRUCTURE |
| 690 | 1 | 0 | |a CHEMOTAXONOMY |
| 690 | 1 | 0 | |a EXTRACTION |
| 690 | 1 | 0 | |a ISOMER |
| 690 | 1 | 0 | |a MOLECULAR MODEL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a SPECTROSCOPY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIMALARIALS |
| 690 | 1 | 0 | |a ERGOSTEROL |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LACTONES |
| 690 | 1 | 0 | |a MAGNETIC RESONANCE SPECTROSCOPY |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a SOLANACEAE |
| 690 | 1 | 0 | |a VASSOBIA |
| 700 | 1 | |a Gil, R.R. | |
| 700 | 1 | |a Oberti, J.C. | |
| 700 | 1 | |a Veleiro, A.S. | |
| 700 | 1 | |a Burton, G. | |
| 773 | 0 | |d 2000 |g v. 63 |h pp. 1329-1332 |k n. 10 |p J. Nat. Prod. |x 01633864 |t Journal of Natural Products | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033753895&doi=10.1021%2fnp000022z&partnerID=40&md5=70100e1f409603afed25e14c328dcd29 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1021/np000022z |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01633864_v63_n10_p1329_Misico |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v63_n10_p1329_Misico |y Registro en la Biblioteca Digital |
| 961 | |a paper_01633864_v63_n10_p1329_Misico |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 63178 | ||